Results 81 to 90 of about 95,709 (300)

Research progress on quality of life of patients with amyotrophic lateral sclerosis

Huli yanjiu, 2016
It introduced quality of life evaluation table and living quality status quo of patients with amyotrophic lateral sclerosis(ALS) and its influence factors.It also introduced care interventions for amyotrophic lateral sclerosis patients from three aspects
MIAO Xiaohui, Geng Dan, YANG Rong
doaj  

Cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A two-centre tract of interest-based DTI analysis

NeuroImage: Clinical, 2018
Background: After the demonstration of a corticoefferent propagation pattern in amyotrophic lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo staging of individual patients by diffusion tensor imaging (DTI ...
Hans-Peter Müller, Federica Agosta, Martin Gorges, Rebecca Kassubek, Edoardo Gioele Spinelli, Nilo Riva, Albert C. Ludolph, Massimo Filippi, Jan Kassubek   +8 more
doaj   +1 more source

Optineurin functions for optimal immunity [PDF]

, 2018
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
core   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Palliative care for patients in the USA with amyotrophic lateral sclerosis: current challenges

Nursing: Research and Reviews, 2015
Gail Houseman,1 Mary Kelley2 1The ALS Association Greater Philadelphia Chapter, Ambler, PA, USA; 2Department of Neurology, ALS Center at Penn Medicine, Philadelphia, PA, USA Abstract: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that ...
Houseman G, Kelley M
doaj  

Association among blood pressure, antihypertensive drugs, and amyotrophic lateral sclerosis

Arquivos de Neuro-Psiquiatria
Background Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease. The impacts of antihypertensive drugs and blood pressure (BP) on ALS are currently debatable.
Zhiguang Li, Yan Li, Jiankai Zhao, Feifei Zhang, Wei Dang, Yanan Jia, Fei Guo, Lixin Guo   +7 more
doaj   +1 more source

Laryngeal sensitivity in patients with amyotrophic lateral sclerosis [PDF]

, 2016
Recent studies have shown the involvement of the sensory nervous system in patients with amyotrophic lateral sclerosis (ALS). The aim of our study was to investigate the correlation between the laryngeal sensitivity deficit and the type of ALS onset ...
BIASIOTTA, ANTONELLA, Buonopane, Ce, CAMBIERI, CHIARA, CECCANTI, MARCO, CRUCCU, Giorgio, DE VINCENTIIS, Marco, FRASCA, VITTORIO, GIORDANO, Carla, GORI, MARIA CRISTINA, GRECO, Antonio, INGHILLERI, Maurizio, ONESTI, EMANUELA, RUOPPOLO, Giovanni, SCHETTINO, ILENIA   +13 more
core   +2 more sources

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis

Cell Reports, 2020
Summary: Neuronal Ca2+ entry elicited by electrical activity contributes to information coding via activation of K+ and Cl− channels. While Ca2+-dependent K+ channels have been extensively studied, the molecular identity and role of Ca2+-activated Cl ...
Claire Soulard, Céline Salsac, Kevin Mouzat, Cécile Hilaire, Julien Roussel, Alexandre Mezghrani, Serge Lumbroso, Cédric Raoul, Frédérique Scamps   +8 more
doaj   +1 more source

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M, Higginbottom, A, Nanou, A, Ning, K, Shaw, P, Valori, CF, Wyles, M   +6 more
core   +1 more source