Results 81 to 90 of about 2,700,197 (262)

Prevalence of amyotrophic lateral sclerosis in the city of Porto Alegre, in Southern Brazil

Arquivos de Neuro-Psiquiatria, 2013
Objective : To determine the prevalence of amyotrophic lateral sclerosis (ALS) in the city of Porto Alegre, Brazil. Method : We conducted an extensive investigation in clinics and hospitals that provide specialized assistance to these patients ...
Eduardo Linden Junior, Jefferson Becker, Pedro Schestatsky, Francisco Tellechea Rotta, Carlo Domenico Marrone, Irenio Gomes   +5 more
doaj   +1 more source

Structural Variants May Be a Source of Missing Heritability in sALS

Frontiers in Neuroscience, 2020
The underlying genetic and molecular mechanisms that drive amyotrophic lateral sclerosis (ALS) remain poorly understood. Structural variants within the genome can play a significant role in neurodegenerative disease risk, such as the repeat expansion in ...
Frances Theunissen, Frances Theunissen, Loren L. Flynn, Loren L. Flynn, Loren L. Flynn, Ryan S. Anderton, Ryan S. Anderton, Ryan S. Anderton, Frank Mastaglia, Frank Mastaglia, Julia Pytte, Julia Pytte, Leanne Jiang, Leanne Jiang, Stuart Hodgetts, Stuart Hodgetts, Daniel K. Burns, Ann Saunders, Sue Fletcher, Sue Fletcher, Steve D. Wilton, Steve D. Wilton, Steve D. Wilton, Patrick Anthony Akkari, Patrick Anthony Akkari, Patrick Anthony Akkari   +25 more
doaj   +1 more source

Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis [PDF]

, 2019
Objective: To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model.
Hashizume, Atsushi, Kishimoto, Yoshiyuki, Ito, Daisuke, Hirakawa, Akihiro, Katsuno, Masahisa, Hijikata, Yasuhiro, Iguchi, Yohei, Iida, Madoka, Yamada, Shinichiro, Moriyoshi, Hideyuki   +9 more
core   +1 more source

Preserving Motor Features by Alternative Re‐Referencing to Remove Heart Artifact on the Stentrode

Advanced Science, EarlyView.
Endovascular brain‐computer interfaces record neural activity from within cerebrovasculature, at the expense of electrocardiogram contamination. Band‐limited independent component analysis separates this heart‐based artifact from task‐relevant neural activity in each frequency band, enabling the reconstruction of cleaner neural recordings without the ...
Ariel K. Feldman, Kriti Kacker, Rahyun Yun, Nikole Chetty, James Bennett, Peter E. Yoo, Raul G. Nogueira, Jennifer L. Collinger, Nicholas L. Opie, Thomas J. Oxley, David F. Putrino, Douglas J. Weber   +11 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

Cell Reports, 2019
Summary: Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs).
Riccardo De Santis, Vincenzo Alfano, Valeria de Turris, Alessio Colantoni, Laura Santini, Maria Giovanna Garone, Giuseppe Antonacci, Giovanna Peruzzi, Emma Sudria-Lopez, Emanuel Wyler, Jasper J. Anink, Eleonora Aronica, Markus Landthaler, R. Jeroen Pasterkamp, Irene Bozzoni, Alessandro Rosa   +15 more
doaj   +1 more source

Meaning in life in patients with amyotrophic lateral sclerosis.

, 2010
The construct 'meaning in life' (MiL) has become increasingly important in palliative care. Several meaning-focused interventions have been developed recently.
Fegg, M.J., Jox, R., Kögler, M., Anneser, J., Wasner, M., Haarmann-Doetkotte, S., Borasio, G.D., Brandstätter, M.   +7 more
core   +1 more source

Detecting neurobehavioral changes in amyotrophic lateral sclerosis

, 2007
Cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) is well documented, but behavioral abnormalities are not well defined. The Frontal Systems Behavior Scale (FrSBe) was used to assess changes in apathy, disinhibition, and executive
Grossman, Alison B, Woolley-Levine, Susan, Bradley, Walter G, Miller, Robert G   +3 more
core   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Molecular Details of RNA Interactions With FUS Condensates Altering Assembly, Dynamics, and Aggregation

Angewandte Chemie, EarlyView.
Using NMR and molecular simulations, we map how RNA engages FUS LC‐RGG1 within condensates through electrostatic, π‐stacking, and polar contacts. These multivalent RNA contacts help stabilize RNA within FUS condensates while also reshaping condensate composition and dynamics.
Tongyin Zheng, Kandarp A. Sojitra, Samara Cummings, Qizan Chen, Priyesh Mohanty, Jeetain Mittal, Nicolas L. Fawzi   +6 more
wiley   +2 more sources