Results 221 to 230 of about 57,256 (260)

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, Volume 13, Issue 21, 13 April 2026.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Gender Differences in Anti-Doping Rule Violations Based on a 19-Year Data Analysis from the Serbian Anti-Doping Agency: National Study. [PDF]

Sports (Basel)
Milovanovic G, Rasic Ozegovic J, Jovicic D, Radivojevic N, Rancic N, Stojicevic J, Marjanović S, Vesic Z, Vukasinovic-Vesic M.   +8 more
europepmc   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Intermittent Fasting and Androgen Receptor Signaling in Prostate Cancer: Metabolic Crosstalk and Therapeutic Implications. [PDF]

Int J Mol Sci
Gromadzka G, Bendykowska M.
europepmc   +1 more source

Dietary Probiotics Improve Growth, Immunity and Disease Resistance in Fish Against Aeromonas hydrophila Infection

Aquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.
Probiotics offer a promising alternative to antibiotics for managing Aeromonas hydrophila infections in aquaculture. Dietary supplementation of probiotics increases fish health, growth performance, and immune responses, while reducing antibiotic reliance in fish farming.
Md. Ridwanul Islam, Md. Adnan Sajib, Nurunnahar Nadira, Alokesh Kumar Ghosh   +3 more
wiley   +1 more source

Little Known Facts, Controversies and Misconceptions About Cranial Motor Nuclei (and a New Classification for All Motoneurons, Cranial, and Spinal)

Journal of Comparative Neurology, Volume 534, Issue 4, April 2026.
ABSTRACT Cranial nerves represent a notoriously complex province of the neuroanatomical landscape of the vertebrates. Here, we offer a selection of the anatomic, genetic, and developmental features of their efferent component that are often misrepresented, ignored or controversial, as a complement to more exhaustive treatments of the subject.
Margaux Sivori, Bowen Dempsey, Jean‐François Brunet   +2 more
wiley   +1 more source

Increase in serum DKK1 levels attenuates the anabolic response to romosozumab in postmenopausal osteoporosis. [PDF]

J Bone Miner Res
Adami G, Montanari F, Fassio A, Pollastri F, Piccinelli A, Benini C, Pasetto E, Tugnolli M, Gatti D, Rossini M, Viapiana O.   +10 more
europepmc   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 916-927, April 2026.
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard, Matthias Schwab, Michelle Whirl‐Carrillo, Ann M. Moyer, Guilherme Suarez‐Kurtz, Ching‐Hon Pui, C. Michael Stein, Teri E. Klein, Claire Spahn, Sooyeon Kwon, Juanda Leo Hartono, Nanne K. de Boer, Tariq Ahmad, Federico Guillermo Antillon‐Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E. J. Yeoh, Kjeld Schmiegelow, Jun J. Yang   +18 more
wiley   +1 more source

Asian Federation of Osteoporosis Societies 2025 consensus on atypical femoral fractures in patients with osteoporosis. [PDF]

Osteoporos Sarcopenia
Valleenukul T, Songpatanasilp T, Jaisamrarn U, Anuraklekha S, Srinonprasert V, Chaiamnuay S, Unnanuntana A, Wattanachanya L, Nimitphong H, Kulachote N, Phruetthiphat OA, Jarayabhand R, Amphansap T, Vanitcharoenkul E, Chotiyarnwong P, Mori S, Kim KK, Yeap SS, Paramasivam SS, Gani L, Cheung CL, Li-Yu J, Sandoval MA, Chen CH, Charatcharoenwitthaya N.   +24 more
europepmc   +1 more source

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre‐Implant Bone Regeneration: A Systematic Review and Meta‐Analysis

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objectives This systematic review and meta‐analysis aimed to evaluate the adjunctive beneficial effects of locally delivered statins on probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP), and radiographic bone outcomes in both periodontal therapy (Step 2 non‐surgical periodontal therapy and Step 3 ...
Koki Yoshida, Sofia Heller, Nur Mousa, Lovisa Olén, Farah Asa'ad   +4 more
wiley   +1 more source