Results 21 to 30 of about 57,256 (260)

Anabolic therapy for osteoporosis: update on efficacy and safety

Archives of Endocrinology and Metabolism, 2022
Anabolic agents for the treatment of osteoporosis increase bone density, improve bone strength, and reduce fracture risk. They are distinguished from antiresorptive drugs by their property of increasing osteoblastic bone formation.
Leonardo Bandeira, E. Michael Lewiecki
doaj   +1 more source

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]

, 2014
The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter, Armstrong, Armstrong, Babij, Bodine, Bodine, Bonewald, Bouxsein, Boyden, Case, Choi, Dallas, Dempster, Diarra, Doube, Galea, Glass, Gong, Hens, Holmen, Holmen, Javaheri, Johnson, Johnson, Johnson, Kamel, Kato, Kitase, Korecki, Kramer, Lau, Li, Little, Logan, Lu, Monga, Nakashima, Nathke, Nusse, Pinson, Polakis, Reya, Robinson, Santos, Sawakami, Saxon, Schneider, Sen, Srivastava, Sunters, Wijenayaka, Xing, Xiong, Yao   +53 more
core   +2 more sources

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H., Henderson, Colin J., MacLeod, A. Kenneth, McLaughlin, Lesley A., McMahon, Michael, Wolf, C. Roland   +5 more
core   +9 more sources

Study on Doping Prevention: A map of Legal, Regulatory and Prevention Practice Provisions in EU 28 [PDF]

, 2014
Historically, anti-doping efforts have focused on the detection and deterrence of doping in elite and competitive sport. There is, however, a growing concern that doping is occurring outside the organised sporting system; giving rise to the belief that ...
Backhouse, SH, Brissonneau, C, Christensen, A, Collins, C, Defoort, Y, Dikic, N, Hauw, D, Horta, L, McNamee, M, McVeigh, J, Parkinson, A, Petrou, M, Sauer, M, Simon, P   +13 more
core   +1 more source

The multi-modality cardiac imaging approach to the Athlete's heart: an expert consensus of the European Association of Cardiovascular Imaging [PDF]

, 2015
The term 'athlete's heart' refers to a clinical picture characterized by a slow heart rate and enlargement of the heart. A multi-modality imaging approach to the athlete's heart aims to differentiate physiological changes due to intensive training in the
Abergel, Abhayaratna, Andersson, Angell, Bartram, Basavarajaiah, Blair, Bossone, Bruder, Caso, Chandra, Corrado, Corrado, D'Andrea, D'Andrea, D'Andrea, D'Andrea, D'Andrea, D'Andrea, D'Andrea, Di Paolo, Douglas, Estorch, Fagard, Fagard, Florescu, Gabrielli, Galderisi, Galderisi, Garber, George, Gilbert, Goldhammer, Grothues, Hauser, Hildick-Smith, Kalliokoski, Kim, Knutsen, La Gerche, La Gerche, Ljungqvist, Mahrholdt, Makan, Maron, Maron, Maron, Maron, Maron, Matsumura, Matsuo, Montgomery, Moon, Moon, Morganroth, Mousavi, Nagueh, Nottin, O'Hanlon, Pattynama, Payne, Pelliccia, Pelliccia, Petersen, Pluim, Prakken, Rehr, Richand, Rickers, Rudski, Saghir, Scharf, Scharhag, Schwartz, Semelka, Sen-Chowdhry, Sen-Chowdhry, Severino, Sharma, Shave, Shave, Spirito, Steinvil, Teramoto, Terry, Thomas, Urhausen, Vinereanu, Whyte, Wolfe, Zeppilli, Zoncu   +91 more
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A Young Man with Myocardial Infarction due to Trenbolone Acetate; a Case Report

Archives of Academic Emergency Medicine, 2018
Over the four decades, a significant decrease has been observed in age-related mortality caused by cardiovascular disease. People in developing countries suffer from CAD at a relatively younger age and about half of MI occurs under the age of fifty years.
Kavous Shahsavari Nia, Farzad Rahmani, Hanieh Ebrahimi Bakhtavr, Yashar Hashemi aghdam, Moloud Balafar   +4 more
doaj   +1 more source

Ethical considerations in human movement research [PDF]

, 1995
In the past decade, ethical issues in research involving human subjects have exploded into the public consciousness. In reviewing past human subject abuse, it is evident that, in human experimentation, legislation has not been sufficient to curb excesses.
Olivier, Steve
core   +2 more sources

Role of Anabolic Anti-Osteoporosis Therapy in Diabetes Subjects

Indian Journal of Endocrinology and Metabolism
Diabetes mellitus (DM) is a metabolic disorder that leads to the destruction of various tissues including bones. The pathogenesis of osteoporosis (OP) varies in DM due to many specific factors.
Harsh Durgia, Rajan Palui, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Dukhabandhu Naik   +4 more
doaj   +1 more source

Advances and Unmet Needs in the Therapeutics of Bone Fragility

Frontiers in Endocrinology, 2018
The prevalence of fragility fractures increases as longevity increases the proportion of the elderly in the community. Until recently, the majority of studies have targeted women with osteoporosis defined as a bone mineral density (BMD) T score of < ...
Sabashini K. Ramchand, Sabashini K. Ramchand, Ego Seeman, Ego Seeman, Ego Seeman   +4 more
doaj   +1 more source

Skeletal muscle: a significant novel neurohypophyseal hormone-secreting organ [PDF]

, 2019
Vasopressin (arg8-vasopressin) and oxytocin are closely relalated hormones, synthesized as pre-hormones in the magnocellular neurons of the paraventricular Q6 and supraoptic nuclei of the hypothalamus.
Dario Coletti, Dario Coletti, Eva Pigna, Marina Bouché, Rosamaria Lugarà, Sergio Adamo, Viviana Moresi   +6 more
core   +2 more sources