Results 61 to 70 of about 29,830 (263)

Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis

Journal of Orthopaedic Surgery and Research
Background While anabolic agents are highly effective in stimulating bone formation, their benefits are transient and tend to plateau after prolonged use. This necessitates a transition to anti-resorptive therapies. We aimed to estimate anti-osteoporosis
Peng Su, Maofu Li, Jian Xiao, Longbin Bai   +3 more
doaj   +1 more source

Use of androgenic anabolic steroids by patients under treatment for substance use disorder: case series

Jornal Brasileiro de Psiquiatria
The present study reports several case studies about the use of androgenic-anabolic steroids (AAS) by patients under treatment for substance use disorder (SUD).
Julio Mario Xerfan do Amaral, Marcelo Santos Cruz   +1 more
doaj   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Sclerostin

Journal of Osteoporosis, 2010
The striking clinical benefits of intermittent parathyroid hormone in osteoporosis have begun a new era of skeletal anabolic agents. One potential new agent is monoclonal antibody to sclerostin, a potent inhibitor of osteoblastogenesis.
Stuart L. Silverman
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

The effects of different doses of Stanozolol on sperm parameters and testicular histology in male rats: An experimental study

International Journal of Reproductive BioMedicine
Background: Stanozolol, an anabolic steroid, has potential therapeutic applications but is also linked to numerous adverse health effects. Objective: This study aimed to assess the effects of different doses of Stanozolol on testicular tissue and ...
Mahmood Neamah Hammood, Hussein Jasim AL-Harbi, Thoalffakar Abbas Alhamed, Hanan Jassim Hammod   +3 more
doaj   +1 more source

Validation of screening method for determination of methyltestosterone in fish [PDF]

Macedonian Veterinary Review, 2013
Anabolic androgenic steroids are synthetic derivatives of testosterone, which is the primary male sex hormone. These anabolic agents are used to increase the weight gain, to improve the food efficiency, storing proteins and to decrease fatness.
Stojkovski Velimir, Todorovic Aleksandra, Dimitrieska-Stojkovic Elizabeta, Stojanovska-Dimzoska Biljana, Hajrulai-Musliu Zehra, Uzunov Risto   +5 more
doaj