Organ-Specific Volatile Profiling of Lactuca tatarica (L.) C.A.Mey. (Asteraceae) Reveals Metabolic Differentiation by MSD-SPME-GC-MS/FID. [PDF]
Chem BiodiversMSD–SPME–GC–MS/FID reveals distinct organ‐specific volatile signatures in Lactuca tatarica. Leaves are dominated by lipid‐derived aldehydes, roots exhibit a mixed profile of aldehydes and terpenoids, and seeds are characterized by aldehydes and aromatic ketones.
Shukurlu EN +4 more
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Synthesis, Structural Characterization, and Investigation of Biological Effects of Novel Benzothiazole-Triazole Derivatives Designed as AKT Kinase Inhibitors. [PDF]
Chem Biol Drug DesNovel benzothiazole‐triazole derivatives were designed and synthesized as potential anticancer agents targeting the PI3K/Akt pathway. Compound 5h exhibited potent Akt1 inhibition, induced apoptosis and mitochondrial dysfunction in MCF‐7 cells, and demonstrated stable binding in molecular docking and dynamics studies, highlighting its promise for breast
Çiftçi B +3 more
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Design, Synthesis, and Investigation of the Biological Activities of New Thiadiazole Derivatives With Anticancer Effects. [PDF]
Chem Biol Drug DesIn silico studies reveal that compound 3c interacts strongly with the active site of the aromatase enzyme. In addition, compound 3c yielded promising results in in vitro enzyme inhibition and cytotoxicity studies. ABSTRACT Breast cancer is one of the most significant diseases in today's world.
Özkay Y +5 more
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Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS-2B Cells: Viability, Apoptosis, and DNA Damage. [PDF]
J Appl ToxicolABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Baysal M +5 more
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Investigation of the In Vitro and In Silico Anticancer Potential of Novel 4-Arylthiazole-Hydrazone Derivatives. [PDF]
Chem Biol Drug DesThe synthesized compounds exhibited excellent cytotoxicity on MCF‐7, breast cancer cell line with selective profile especially 2d with IC50 value of 0.12 μM. Three compounds 2c, 2d, and 2h caused almost as much apoptosis induction as cisplatin. Compound 2d exhibited caspase‐3 activation at standard drug level.
Demirci ZZ +3 more
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Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors. [PDF]
Drug Dev ResABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Doğan MO +6 more
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Gephyra, 2022 Hellenistic and Roman grave steles in Asia Minor were usually produced and put in place for a unique, specific purpose and intended for eternal display at the tomb.
Eva Christof
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Enantioselective Determination of Upadacitinib in Pharmaceutical Formulations Using Reversed‐Phase Chiral Liquid Chromatography [PDF]
J Sep SciA reversed‐phase chiral HPLC method was developed for the enantioselective separation and quantification of upadacitinib using a Box‐Behnken design. The validated method was successfully applied to the quantification of upadacitinib in a commercial tablet formulation, and its environmental impact and practicality were evaluated using various assessment
Atila Karaca S, Aliyeva S, Yeniceli D.
europepmc +2 more sources
11. Yüzyılda Anadolu'nun Kaybı Aile Antroponimisinde İzler Bıraktı Mı?
Ortaçağ Araştırmaları Dergisi, 2021 Anadolu 11. Yüzyılın ikinci yarısında Bizans ve Selçuklu ordularının savaş yeri haline gelmiştir. Jean Claude Cheynet'in "La perte de l' Asie Mineure au XIe siècle: A-t-elle laissé des traces dans l' anthroponymie familiale?”" (11.
Sait Emre Çiftçi
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İttihat ve Terakki'nin Müslümanları İskan Politikası (1913-1918)
Yakın Doğu Üniversitesi İslam Tetkikleri Merkezi Dergisi, 2021 Fuat Dündar’ın “İttihat ve Terakki’nin Müslümanları iskan politikası” isimli kitabı, İttihat ve Terakki Cemiyeti'nin tam iktidar olduğu dönemde, Anadolu'nun Müslümanlaşması ve Türkleşmesi ideolojisi doğrultusunda uygulanan göç ve iskan politikalarını ...
Meryem Sezgin
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