Results 101 to 110 of about 273,502 (301)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Incline dependence of the power-duration relationship in cross-country skiing

Frontiers in Physiology
IntroductionThis study aimed to develop a methodology for establishing the power–duration relationship in cross-country skiers and to investigate the influence of incline on critical power (CP) model parameters.MethodsTwelve trained male cross-country ...
Marton Horvath, Erik P. Andersson, Adam Kölnas, Adam Spreitz, Hjalmar Boström, Arvid Sörfeldt, Dan Kuylenstierna   +6 more
doaj   +1 more source

Relationships between Different Field Test Performance Measures in Elite Goalball Players

Sports, 2018
Goalball is a Paralympic sport involving people with visual impairment. Little is known about the physical fitness of elite players of this sport, as previous studies only evaluated body composition and aerobic capacity.
Gabriel Goulart-Siqueira, Stefano Benítez-Flores, Alexandre R. P. Ferreira, Alessandro M. Zagatto, Carl Foster, Daniel Boullosa   +5 more
doaj   +1 more source

The Effects and Differences of Sprint Interval Training, Endurance Training and the Training Types Combined on Physiological Parameters and Exercise Performance [PDF]

, 2014
Sprint Interval Training (SIT) is a time efficient way in order to elicit similar changes as Endurance Training (ET) on aerobic capacity, with the purpose of the exercise training to alter physiological systems and exceed resting homeostasis to improve ...
Hurst, Rachel Ann
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Effect of training on the anaerobic capacity.

Medicine and science in sports and exercise, 1990
Intense exercise of short duration is heavily dependent on energy from anaerobic sources, and subjects successful in anaerobic types of sports may therefore have a larger anaerobic capacity and be able to release energy at a higher rate. Performances in these kinds of sports are improved by training, suggesting that the anaerobic capacity is trainable.
J I, Medbø, S, Burgers
openaire   +4 more sources

Anaerobic power as a key predictor of performance in elite kayaking

Human Movement
Purpose The balance of low- and high-intensity training, reflecting aerobic and anaerobic capacities, respectively, varies by sport and discipline. Yet their specific contributions in male flat-water kayaking remain poorly understood. This study aimed to
Tomáš Mika, Jiří Millek, Emil Bolek, Matylda Malá, Miroslava Nováková   +4 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Estimation of Costs of Phosphorus Removal In Wastewater Treatment Facilities: Adaptation of Existing Facilities [PDF]

, 2005
As part of a wider enquiry into the feasibility of offset banking schemes as a means to implement pollutant trading within Georgia watersheds, this is the second of two reports addressing the issue of estimating costs for upgrades in the performance of ...
D. Russell, F. Jiang, Kristin Rowles, M. Bruce Beck, Ronald G. Cummings   +4 more
core