Results 191 to 200 of about 345,476 (333)

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Carbohydrates as a source of energy and matter for the origin of life [PDF]

Recently, we proposed a new model of early glycolysis in which the oxidation of glyceraldehyde self-hemiacetals yielded energy rich polyglyceric acid instead of energy rich thioesters.
Weber, A. L.
core   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Nonenzymatic formation of energy-rich lactoyl and glyceroyl thioesters from glyceraldehyde and a thiol [PDF]

The energy rich thioester, N-acetyl-S-lactoylcysteine, is formed under anaerobic conditions from glyceraldehyde and N-acetylcysteine at ambient temperature in aqueous solutions of sodium phosphate (pH 7.0).
Weber, A. L.
core   +1 more source

Influence of opioids on activity of enzymes in kidneys at no-induced apoptosis

RUDN Journal of Medicine, 2009
The influence of dalarginum on activity of enzymes SOD and LDG in cells of a kidney is investigated at the production of nitric oxide. In experiment the infringement of enzymes activity is installed: the activation of anaerobic glycolysis and oppression ...
I A Komarevtseva, K V Komarevtseva, Y A Belous   +2 more
doaj  

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Effect of High‐Intensity Interval Training With Varying Work‐to‐Rest Ratios on Specific Physical Fitness in Adolescent Taekwondo Athletes

European Journal of Sport Science, Volume 25, Issue 10, October 2025.
ABSTRACT This study investigated the effects of high‐intensity interval training (HIIT) with different work‐to‐rest ratios during the same training duration on the specific physical fitness of Chinese adolescent taekwondo athletes (N = 30, 16–20 years, 18 males and 12 females, and provincial champion/runner‐up or national top 6). Athletes were randomly
Ning Xu, Yadong Xue, Meng Zhang
wiley   +1 more source

Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection

Glia, Volume 73, Issue 10, Page 2003-2024, October 2025.
Main Points Toxoplasma infection results in distinct astrocyte subpopulations. Chronically labeled reactive astrocytes appear transcriptionally plastic and can regain acute inflammatory responding and naive homeostatic astrocytic gene patterns in the presence of ongoing neuroinflammation.
Zoe A. Figueroa, Jose L. Martin, Arzu Ulu, William Agnew‐Svoboda, Teresa Ubina, Martin M. Riccomagno, Todd A. Fiacco, Emma H. Wilson   +7 more
wiley   +1 more source

Genomic Analysis for the Safety Assessment of a Potential Probiotic Strain Pediococcus pentosaceus BBS1 Isolated From Lao Fermented Bamboo Shoots (Nor Mai Som)

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Pediococcus pentosaceus BBS1 was analyzed by whole genome sequencing for its classification, annotated its main features for significant genes, and safety characteristics. The strain has the potential to be used as a beneficial probiotic starter culture, improving the quality of the fermented bamboo and related products. ABSTRACT Currently, there is an
Viengvilaiphone Botthoulath, Ida F. Dalmacio, Francisco B. Elegado, Lawrence Yves Uy, Hsiang‐Chun Lin   +4 more
wiley   +1 more source

Oligoglyceric acid synthesis by autocondensation of glyceroyl thioester [PDF]

The autocondensation of the glyceroyl thioester, S-glyceroyl-ethane-thiol, yielded olioglyceric acid. The rates of autocondensation and hydrolysis of the thioester increased from pH 6.5 to pH 7.5 in 2,6-lutidine and imidazole buffers.
Weber, A. L.
core   +1 more source