Results 171 to 180 of about 314,893 (262)

Microbial Characteristics of Weissella cibaria HRL3 and Its Immunostimulatory Effects via TLR3/TLR9‐Dependent IFN‐α Production

open access: yesJournal of Food Science, Volume 91, Issue 11, November 2026.
ABSTRACT Rhinacanthus nasutus (L.) Kurz is a medicinal plant whose roots, stems, and leaves are commonly used in tea and traditional Chinese medicine; however, the beneficial effects of its flowers remain to be investigated. In this study, the lactic acid bacteria (LAB) found in the flowers of R.
Fumie Niitsuma   +6 more
wiley   +1 more source

Integrated Microbial Profiling Identifies Bacterial and Fungal Communities in Pseudomyxoma Peritonei Mucin

open access: yesMicrobial Biotechnology, Volume 19, Issue 11, November 2026.
Integrated profiling of pseudomyxoma peritonei mucin revealed bacterial and fungal communities spatially supported by rRNA detection. Bacterial communities also displayed histological grade‐associated differences in predicted metabolic pathways, supporting PMP mucin as a complex multi‐kingdom microbial environment. ABSTRACT Pseudomyxoma peritonei (PMP)
Rafaela Pezzopane   +13 more
wiley   +1 more source

H3K18 Lactylation in Degenerated Nucleus Pulposus Cells Suppresses CD248 Through Transcriptional and Post‐Translational Modifications to Promote Apoptosis and Extracellular Matrix Degradation

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
The high lactate levels in degenerated intervertebral discs promote lactylation of NP cells. H3K18la inhibits the synthesis of CD248 mRNA by recruiting SMARCA5 and promotes the protein degradation of CD248 through the ubiquitin–proteasome pathway, thereby inducing apoptosis of NP cells and degradation of ECM.
Yiming Ma   +7 more
wiley   +1 more source

Biochar‐Driven Microbial Shifts Enhance Feed Digestibility and Mitigate Methane Emissions in Hybrid Pennisetum Silage

open access: yesGCB Bioenergy, Volume 18, Issue 11, November 2026.
This study investigated the effects of cellulase, propionate, and cow dung biochar as additives on the silage quality of hybrid Pennisetum. The results indicated that the incorporation of biochar not only improved fermentation quality but also reduced methane production and enhanced in vitro dry matter digestibility.
Jie Qiao   +4 more
wiley   +1 more source

Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou   +5 more
wiley   +1 more source

Engineering Anaerobic Metabolic Branch Points to Control Carbon Allocation Between Wax Ester Synthesis and Succinate Accumulation in Euglena gracilis

open access: yesJournal of Eukaryotic Microbiology, Volume 73, Issue 6, November/December 2026.
ABSTRACT Under anaerobic conditions, Euglena gracilis degrades paramylon and synthesizes wax esters (WEs) while accumulating succinate in the culture supernatant. Succinate can either be converted to succinyl‐CoA by succinyl‐CoA synthetase (SCS) and enter the propionyl‐CoA biosynthetic pathway or accumulate extracellularly.
Rikuto Oishi   +4 more
wiley   +1 more source

Sex differences in the prefrontal cortex and muscle oxygenation during exercise until exhaustion in endurance‐trained individuals

open access: yesExperimental Physiology, Volume 111, Issue 11, Page 5136-5153, 1 November 2026.
Abstract figure legend During cardiopulmonary exercise testing, the decline in oxygenation in the prefrontal cortex of women is striking. This crucial brain area is directly involved in planning motor tasks. The decline is particularly pronounced at higher exercise intensities, especially after reaching the respiratory compensation point or anaerobic ...
Daniel Ramos‐López   +12 more
wiley   +1 more source

Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo   +5 more
wiley   +1 more source

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