Results 161 to 170 of about 314,893 (262)

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Metformin Promotes Cholangiocyte Regeneration in Cholestatic Fibrosis via HK1‐Glycolysis‐Dependent Epigenetic Activation of LGR5

MedComm, Volume 7, Issue 11, November 2026.
Metformin activates the HK1–glycolysis–acCoA–H4K16ac–LGR5 axis to promote cholangiocyte regeneration and suppress EMT‐like phenotypes in cholestatic liver fibrosis. Mechanistically, metformin upregulates HK1‐driven glycolysis, increasing acetyl‐CoA availability for H4K16ac enrichment at the Lgr5 promoter, which transcriptionally activates LGR5.
Yingyu Liang, Yongqin Ye, Haoran Lian, Zhejun Song, Xiaowen Bao, Yue Peng, Wenxia Zhang, Qingyu Lu, Weilu Wang, Yiling Chen, Vincent Chi Hang Lui, Fotios Sampaziotis, Paul Kwong Hang Tam, Yan Chen   +13 more
wiley   +1 more source

Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis. [PDF]

Elife
Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Fujita S, Morikawa T, Koide S, Oshima M, Nishiyama A, Murakami K, Haraguchi M, Tamaki S, Yamamoto T, Yabushita T, Tanaka Y, Nagamatsu G, Honda H, Okamoto S, Goda N, Tamura T, Nakamura-Ishizu A, Suematsu M, Iwama A, Suda T, Takubo K.   +27 more
europepmc   +1 more source

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, November 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Bufalin-Loaded Multifunctional Photothermal Nanoparticles Inhibit the Anaerobic Glycolysis by Targeting SRC-3/HIF-1α Pathway for Improved Mild Photothermal Therapy in CRC. [PDF]

Int J Nanomedicine
Shang J, Xia Q, Sun Y, Wang H, Chen J, Li Y, Gao F, Yin P, Yuan Z.   +8 more
europepmc   +1 more source

Gastroschisis‐Like Defect in a Crossbred Bovine Calf: Anatomical, Clinical and Surgical Perspectives

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
A gastroschisis‐like defect was observed in a one‐day‐old, crossbred bovine calf with evisceration of the pyloric abomasum and small intestine, likely resulting from prenatal rupture of an omphalocele. The calf presented with lethargy, hypothermia and metabolic derangements, along with elevated renal biomarkers.
Mohammad Raguib Munif, Tanjin Tamanna Mumu   +1 more
wiley   +1 more source

Host Development and Environment Influence the Microbiomes of Aquatic Insects and Riparian Spiders

Environmental Microbiology, Volume 28, Issue 11, November 2026.
Aquatic insect larvae had higher microbiome diversity than adult life stages, and there was greater retention of larvae‐derived bacterial taxa in adults of hemi‐ compared to holometabolous insects. Wastewater treatment plant effluents decreased endosymbionts in aquatic insects and increased predicted xenobiotic degradation pathways across larvae ...
Milena Esser, Brittany Perrotta, Karen Kidd   +2 more
wiley   +1 more source

ANAEROBIC GLYCOLYSIS BY ENZYME PREPARATIONS OF BRUCELLA SUIS

Journal of Biological Chemistry, 1952
W G, ROESSLER, T H, SANDERS, J, DULBERG, C R, BREWER   +3 more
openaire   +2 more sources

Lachnospiraceae in the Food–Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT The interplay between diet, gut microbiota, and host immunity is central to food science. The Lachnospiraceae family ferments dietary fibers to produce short‐chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential. This critical review distinguishes established findings from hypotheses.
Ruijun Wang, Zhiqi Li, Lina Zhang, Yuanming Pan, Zhanbiao He   +4 more
wiley   +1 more source