Results 151 to 160 of about 41,612 (257)

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak, Nebih Lolak, Andrea Ammara, Gökçenur Gürbüz, Ibrahim Bozgeyik, Demet Taşdemir, Hamada Hashem, Stefan Bräse, Claudiu T. Supuran   +8 more
wiley   +1 more source

Metabolomics Reveals Reasons for the Efficacy of Acupuncture in Migraine Patients: The Role of Anaerobic Glycolysis and Mitochondrial Citrate in Migraine Relief. [PDF]

Phenomics
Gao Z, Yan X, Wang-Sattler R, Covic M, Yu G, Ge F, Lin J, Chen Q, Liu J, Sharma S, Molnos S, Kuehnel B, Wilson R, Adam J, Brandmaier S, Yu S, Liang F, Gieger C.   +17 more
europepmc   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia. [PDF]

PLoS One, 2018
Chan TS, Cassim S, Raymond VA, Gottschalk S, Merlen G, Zwingmann C, Lapierre P, Darby P, Mazer CD, Bilodeau M.   +9 more
europepmc   +1 more source

Linezolid‐induced lactic acidosis in critically ill patients: A multicentre study of incidence, severity and predictors

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2239-2249, July 2026.
Abstract Introduction Linezolid, a synthetic oxazolidinone for resistant gram‐positive infections, is generally associated with mild adverse effects such as gastrointestinal disturbances, but more serious reactions like lactic acidosis (LA) have also been reported.
Lina Naseralallah, Bodoor Aboujabal, Zahra Noureddine, Khaled Aboujabal, Somaya Koraysh   +4 more
wiley   +1 more source

Correction: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis. [PDF]

Cell Death Dis
Lu C, Qiao P, Fu R, Wang Y, Lu J, Ling X, Liu L, Sun Y, Ren C, Yu Z.   +9 more
europepmc   +1 more source

Artificial intelligence and oral microbiome: Reshaping the diagnostic and therapeutic paradigm of OSCC

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Schematic overview showing how microbiota‐induced epithelial dysbiosis initiates OSCC pathogenesis; multi‐omics sequencing paired with machine learning modelling constructs predictive biomarkers; the resultant high‐precision prediction tools support early tumour screening, lymph node metastasis risk evaluation and individualised targeted treatment for ...
Rui Shi, Yuan Zhi, Ling Gao, Shao‐Ming Li, Ke‐Qian Zhi, Wen‐Hao Ren   +5 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source