Results 131 to 140 of about 314,893 (262)

Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study.

PLoS Computational Biology
Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional.
Pahala Gedara Jayathilake, Pedro Victori, Clara E Pavillet, Chang Heon Lee, Dimitrios Voukantsis, Ana Miar, Anjali Arora, Adrian L Harris, Karl J Morten, Francesca M Buffa   +9 more
doaj   +1 more source

Characterising the plasma metabolome following high intensity interval exercise in continuous and intermittent hypoxia in overweight individuals

Experimental Physiology, EarlyView.
Abstract The aim of this work was to examine changes in the plasma metabolome in response to high‐intensity interval exercise (HIIE) performed under three distinct hypoxia protocols. On separate days, 18 inactive individuals with overweight completed a HIIE protocol in randomised conditions: normoxia (NEx‐NRec), normobaric hypoxia (inspired O2 fraction
Jacky Soo, Maartje Cox, Paul Goods, Olivier Girard, Louise Deldicque, Monique Ryan, Philipp Nitschke, Nathan Lawler, Timothy Fairchild   +8 more
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

ANAEROBIC GLYCOLYSIS IN NERVOUS TISSUE

Journal of Biological Chemistry, 1945
M F, UTTER, H G, WOOD, J M, REINER
openaire   +2 more sources

AZIONE DEL PROGESTERONE SUL METABOLISMO DI SEZIONI SOPRAVVIVENTI DI ALCUNI TUMORI SPERIMENTALI

, 1954
Researches have been carried out (with Warburg apparatus) on the action of progesteron on respiration aerobic and anaerobic glycolysis of Ehrlich adenocarcinoma and benzopyrene sarcoma.
A. Albano
core   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance. [PDF]

Biosci Rep, 2020
Liu P, Chen T, Tan F, Tian J, Zheng L, Deng Y, Chen J, Chi X.   +7 more
europepmc   +1 more source

Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers

The Journal of Physiology, EarlyView.
Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia, Matthew Lees, John O'Hara, Nathan Hodson, Jordan Acheson, Oliver Wilson, Paul Parker, Matthew Barlow   +7 more
wiley   +1 more source

LncRNA-DANCR Interferes With miR-125b-5p/HK2 Axis to Desensitize Colon Cancer Cells to Cisplatin vis Activating Anaerobic Glycolysis. [PDF]

Front Oncol, 2020
Shi H, Li K, Feng J, Liu G, Feng Y, Zhang X.   +5 more
europepmc   +1 more source