Results 211 to 220 of about 335,029 (357)

Enhanced detection of glutamate via transverse relaxation encoding with narrowband decoupling in the human brain

open access: yesMagnetic Resonance in Medicine, Volume 93, Issue 6, Page 2278-2286, June 2025.
Abstract Purpose This study aims to improve the detection of glutamate (Glu) concentration and T2 using an enhanced transverse relaxation encoding with narrowband decoupling (TREND) technique. Methods A new editing pulse was designed to simultaneously invert both Glu H3 spins (2.12 ppm and 2.05 ppm) while minimizing the excitation of Glu H4 ...
Li An   +6 more
wiley   +1 more source

Pyruvate Kinase Function Correlates With Red Blood Cell Properties and Clinical Manifestations in Sickle Cell Disease

open access: yesAmerican Journal of Hematology, Volume 100, Issue 5, Page 785-796, May 2025.
ABSTRACT Pyruvate kinase (PK) is a key enzyme involved in the final step of glycolysis, essential to produce adenosine triphosphate (ATP). Relatively decreased red blood cell (RBC) PK activity (reflected by a lower PK/hexokinase [HK] ratio) and PK thermostability (PK activity after exposure to heat) were recently identified as pathophysiological ...
M. J. M. Traets   +17 more
wiley   +1 more source

From Sprint to Endurance: Performance Level and Pacing Profile of International Level Para‐Cyclists From C Division

open access: yesEuropean Journal of Sport Science, Volume 25, Issue 5, May 2025.
ABSTRACT We investigated how para‐cycling sport classes in the C division influence performance levels and pacing profiles in track and road races compared to able‐bodied cyclists. For track races, we analyzed data from seven UCI World Para‐Cycling Track Championships and UCI World Track Championships (2014–2023) in the male's 1 km time trial and ...
Bryan Le Toquin   +6 more
wiley   +1 more source

Influence of opioids on activity of enzymes in kidneys at no-induced apoptosis

open access: yesRUDN Journal of Medicine, 2009
The influence of dalarginum on activity of enzymes SOD and LDG in cells of a kidney is investigated at the production of nitric oxide. In experiment the infringement of enzymes activity is installed: the activation of anaerobic glycolysis and oppression ...
I A Komarevtseva   +2 more
doaj  

β3‐Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta

open access: yesMedicinal Research Reviews, Volume 45, Issue 3, Page 842-866, May 2025.
ABSTRACT At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia‐inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low‐oxygen environment, including the induction of specific enzymes ...
Luca Filippi   +9 more
wiley   +1 more source

Hyperpolarized 13C‐MRS can Quantify Lactate Production and Oxidative PDH Flux in Murine Skeletal Muscle During Exercise

open access: yesNMR in Biomedicine, Volume 38, Issue 5, May 2025.
This validated combining hyperpolarized [1‐13C]pyruvate MRS with in vivo muscle stimulation to assess skeletal muscle metabolism during exercise in real time. Mice underwent MRS pre/post gastrocnemius stimulation, measuring conversion of [1‐13C]pyruvate to lactate and bicarbonate.
M. Kate Curtis   +10 more
wiley   +1 more source

Dynamics of Ionic and Cytotoxic Edema During Acute and Subacute Stages of Patients With Ischemic Stroke: Complementarity of 23Na MRI and Diffusion MRI

open access: yesNMR in Biomedicine, Volume 38, Issue 5, May 2025.
Regions with ionic edema showed a non‐linear increase in 23Na signal during the first 70 h, with faster and larger sodium accumulations in regions progressing to necrosis at 3. Ionic edema imaging in the subacute phase of stroke may provide additional insights into tissue viability and delayed changes in sodium metabolism.
Maëva Cotinat   +9 more
wiley   +1 more source

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