Results 211 to 220 of about 350,338 (294)

Nuclear spin hyperpolarization of pyruvate enables longitudinal monitoring of treatment response in intestinal tumor organoids

open access: yesMagnetic Resonance in Medicine, Volume 94, Issue 6, Page 2567-2577, December 2025.
Abstract Purpose Colorectal cancer, a leading cause of death in the Western world, is increasingly affecting younger populations. The Warburg effect, characterized by enhanced lactate production, is a hallmark of this cancer type. Although 18F‐FDG PET‐CT is commonly used for diagnosis, MRI offers higher spatial and chemical resolution without the ...
Josh P. Peters   +8 more
wiley   +1 more source

Lactate‐mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension

open access: yesThe Journal of Pathology, Volume 267, Issue 4, Page 399-409, December 2025.
Abstract Chronic myeloid leukemia (CML) is a stem cell‐driven neoplasia characterized by the expression of the constitutively active tyrosine kinase (TK) BCR/Abl. Under low oxygen, a condition that characterizes stem cell niches (SCNs) in vivo, the oncogenic BCR/Ablprotein is suppressed.
Giulio Menegazzi   +5 more
wiley   +1 more source

Artificial Enzymatic Electrochemistry

open access: yesChemElectroChem, Volume 12, Issue 21, November 3, 2025.
Artificial enzymatic electrochemistry has emerged as an effective method to extend the catalytic abilities of enzymes. This review explores the bioelectrochemical methods used to understand and optimize the structure and function of artificial enzymes.
Nya E. Black   +3 more
wiley   +1 more source

Microwave‐Activated Bacterial Biorobot for Multimodal Cancer Therapy

open access: yesAdvanced Science, Volume 12, Issue 41, November 6, 2025.
An Escherichia coli bacterial biorobot is engineered for localized microwave activation in cancer therapy. Upon activation at tumor sites, the biorobot releases glucose oxidase, inducing tumor cell death via glucose depletion and H2O2 generation catalyzed by Cu2O.
Huilan Zhuang   +9 more
wiley   +1 more source

A “Mesoporous Oxygen Chamber” Scaffold with Antibacterial and Early Immunomodulatory Effect for Promoting Bone Regeneration

open access: yesAdvanced Science, Volume 12, Issue 41, November 6, 2025.
In this study, an oxygen‐loaded and antimicrobial peptide (AP)‐functionalized scaffold (MBGAPO) is synthesized. With mesoporous structure of MBG applied as an “oxygen storage,” and AP‐provided antibacterial ability against E.coli and MRSA. MBGAPO exhibited osteogenic and multiplex‐immunomodulatory effects.
You Fu   +7 more
wiley   +1 more source

Graphitized Biochar Derived from Agricultural Wastes Enhances Methanogenesis via Conductivity‐Driven Direct Interspecies Electron Transfer

open access: yesAdvanced Science, Volume 12, Issue 41, November 6, 2025.
This work clarifies how feedstocks and their structural features promote methanogenesis, and identifies the key regulatory factors, reducing pollution to the global environment, and also helps to alleviate the energy crisis. This is the first study to systematically link feedstock lignin content, pyrolysis conditions, biochar graphitization, and DIET ...
Caiyun Yang   +18 more
wiley   +1 more source

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