Results 51 to 60 of about 211,643 (268)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Role of Infiltrative Local Anaesthesia in Thyroidectomy

The Annals of African Surgery, 2013
Background: General anaesthesia is the anaesthetic agent of choice during thyroidectomy, however, recent reports there is a role for local anaesthesia. This study reports on the experience of thyroidectomy performed under infiltrative local anaesthesia ...
Ojuka KD, Saidi H, Rere EC
doaj  

Anaesthetic complications in plastic surgery

Indian Journal of Plastic Surgery, 2013
Anaesthesia related complications in plastic surgeries are fortunately rare, but potentially catastrophic. Maintaining patient safety in the operating room is a major concern of anaesthesiologists, surgeons, hospitals and surgical facilities ...
Soumya Sankar Nath, Debashis Roy, Farrukh Ansari, Sundeep T. Pawar   +3 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

THE EFFECTS OF GENERAL AND EPIDURAL ANAESTHESIA ON THE NUMBER OF LEUCOCYTES AND THE DISTRIBUTION OF LEUCOCYTES SUBGROUPS

Eurasian Journal of Medicine, 2019
General and regional anaesthesia, along with surgery compromise the immun system and affect the number and sugroup distribution of leucocytes. In this study we aimed to compere the number of leucocytes and subgroups in patients who received general ...
Nazım Doğan, Hüsnü Kürşad, Hacı Ahmet Alıcı, Mehmet Cesur   +3 more
doaj  

Effects of computer-assisted and conventional local anaesthesia on pain and anxiety in children with molar incisor hypomineralisation: a randomized controlled clinical trial

BMC Oral Health
Background This prospective study aimed to comparatively investigate the effects of conventional mandibular anaesthesia and digital mandibular and intraosseous anaesthesia administered using the computer-assisted local anaesthesia device (SleeperOne 5 ...
Sercan Dogan, Meryem Sahin, Senay Balci
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Stability of Nasoendotracheal Tube with Transeptal Flower Stitch versus Simple Surgical Knot in Patients undergoing Maxillofacial Trauma Surgery: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Nasoendotracheal (NET) tubes are exposed to various external forces, handling, slippage, and accidental extubation, with the potential for fatal complications.
Riddhi H Mahalle, Nitin Bhola, Anchal Agarwal, Swapnil Jain, Shrenik Chouradiya   +4 more
doaj   +1 more source

Anaesthesia for neuroradiology [PDF]

Canadian Journal of Anaesthesia, 1997
The field of radiology is a rapidly expanding and growing area in the investigation and treatment of central nervous system diseases. The role of the anaesthetist will continue to be important in the management of these patients. The anaesthetist must be prepared to modify and adapt to the changes in techniques, procedures, and to the requirements of ...
openaire   +2 more sources