Results 61 to 70 of about 512,566 (210)

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, Volume 183, Issue 12, Page 3377-3394, June 2026.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

TYRO3, AXL, MERTK and Their Ligands in Brain Metastases From Colorectal Cancers

Cancer Medicine, Volume 15, Issue 5, May 2026.
TYRO3, AXL, and MERTK are expressed in primary tumors and extra‐cerebral and brain metastases from colorectal cancers. AXL, primarily expressed in endothelial cells, is the more conserved marker between primary tumor and brain metastasis. The Low AXL/High GAS6 ratio is of poor prognosis in metastatic colorectal cancer patients.
Anaïs Noblanc, Fatima Dkhissi, Pierre‐Olivier Guichet, Lucie Lebeau, Serge Milin, Sheik Emambux, Pauline Roussille, Camille Evrard, Lucie Karayan‐Tapon, David Tougeron, Omar Benzakour, Violaine Randrian   +11 more
wiley   +1 more source

Lipidome Analysis of Cancer Cells and Their Extracellular Vesicles Reveals Cancer‐Type‐Specific Lipid Signatures and Enables the Design of EV‐Mimetic Liposomes

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Lipid metabolism reprogramming is a hallmark of cancer, yet the global lipidome of cancer cells and their extracellular vesicles (EVs) remains poorly understood. Using mass spectrometry, we analyzed the lipid profiles of a panel of human cancer and non‐cancer cell lines along with their secreted EVs.
Noélie Douanne, Yousra Benslimane, Rubén R. López, Prisca Bustamante, Thupten Tsering, Yunxi Chen, Laura Kienzle, Masoud Ghasemi, Lorne Taylor, Yuning Chen, Anaïs Toreja Boutin, David Juncker, Catherine Mounier, Vahé Nerguizian, Julia V. Burnier   +14 more
wiley   +1 more source

Anais do XVII Simpósio Internacional de Atividades Físicas (SIAFIS - 2017) Errata

Revista de Educação Física, 2018
Anais do XVII Simpósio Internacional de Atividades Físicas (SIAFIS - 2017) Errata: Resumo apresentado no evento, cujos anais foram publicados no volume 86, nr. 2 (junho de 2017).
IPCFEx Exército Brasileiro
doaj  

Black holes production in self-complete quantum gravity

, 2012
A regular black hole model, which has been proposed by Hayward, is reconsidered in the framework of higher dimensional TeV unification and self-complete quantum gravity scenario (Dvali, Spallucci).
Smailagic, Anais, Spallucci, Euro
core   +1 more source

Real‐World Effectiveness and Safety of Pegzilarginase Treatment in Arginase 1 Deficiency

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Pegzilarginase is the first disease‐modifying drug for arginase 1 deficiency. In clinical trials, pegzilarginase effectively normalised plasma arginine (pArg), which was associated with clinically relevant improvements in neuromotor outcomes. We report from a French early access scheme the first report on experience from pegzilarginase therapy
Anaïs Brassier, Alina Arion, Jean‐Baptiste Arnoux, Magalie Barth, Dries Dobbelaere, Magali Gorce, Michael Grövdal, Cécile Laroche, Olivia Rime, Manuel Schiff, Mattias Rudebeck   +10 more
wiley   +1 more source

Why Do They Do What They Do? A Model That Describes and Connects the Drivers of Learning Assistant Facilitation Practices

Science Education, Volume 110, Issue 3, Page 947-973, May 2026.
ABSTRACT Learning assistants (LAs) help implement evidence‐based teaching in undergraduate active‐learning courses and support student learning through their facilitation. Here, we present a drivers‐of‐LA‐action model with empirical evidence that connects across the macro level of LA‐supported course design and the micro level of LA‐student ...
Nicolette M. Maggiore, Jessica M. Karch, Vesal Dini, Ira Caspari‐Gnann   +3 more
wiley   +1 more source

Towards Decarbonisation: Reducing Emissions From Transport in Olympic Host Cities

WIREs Climate Change, Volume 17, Issue 3, May/June 2026.
Hosting the Olympic and Paralympic Games creates both substantial environmental impacts and a window of opportunity for significant climate action through urban transport decarbonisation. Specific economic, policy, and social factors shape interventions undertaken by host city decision‐makers, significantly influencing transport emissions and offering ...
Anais Fabre, Aysin Dedekorkut‐Howes, Millicent Kennelly, Michael Howes   +3 more
wiley   +1 more source

Saculite anal polimicrobiana em cão com hipotireoidismo: Relato de caso

Pubvet, 2017
Relata-se um caso de saculite anal em um canino de nove anos, macho, Cocker Spaniel, com hipotireoidismo. O animal apresentava constipação, havendo melhora após tratamento com levotiroxina.
Fernanda Vieira Henrique, Lilianne Marinho dos Santos, Carla Lauise Rodrigues Menezes Pimenta, Pedro Gustavo Santos Nóbrega, Rosileide dos Santos Caneiro, Felício Garino Júnior   +5 more
doaj   +1 more source

Introduction: A Mnemosyne of Art & Science

Renaissance Studies, EarlyView.
Ana Duarte Rodrigues, Luís Campos Ribeiro, Henrique Leitão   +2 more
wiley   +1 more source