Results 1 to 10 of about 223,855 (315)

Design, Synthesis, and Biological Evaluation of Dual c-Met/HDAC Inhibitors Bearing 2-Aminopyrimidine Scaffold

Pharmaceutical Fronts, 2020
A series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors.
Qingwei Zhang, Guili Xu, Ya Bao, Minru Jiao, Jianqi Li   +4 more
doaj   +3 more sources

Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34

Microbial Cell Factories, 2022
Background Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain.
Zhenxin Li, Songbai Yang, Zhengyu Zhang, Yuanjie Wu, Jiawei Tang, Luoju Wang, Shaoxin Chen   +6 more
doaj   +1 more source

Fabrication and evaluation for the novel ranitidine hydrochloride resinates and calculation of the kinetics and thermodynamics parameter for the ion exchange process

Pakistan Journal of Pharmaceutical Sciences, 2021
Ranitidine hydrochloride (RH) resinates were prepared by bath method using a highly acidic cation-exchange resin as the carrier. The drug-resinates combination pattern was characterized by DSC and X-ray diffraction. The influences of the types of the ion-
Yongjian Yang, Yi DuHaibing He, Yang Yu, Dongli Li, Hongfei Liu, Jiangsu Sunan Pharmaceutical Industry Co., Ltd, Zhenjiang, Ltd., Nantong, PR China   +10 more
doaj   +1 more source

Discovery of SIPI6473, a New, Potent, and Orally Bioavailable Multikinase Inhibitor for the Treatment of Non-small Cell Lung Cancer

Pharmaceutical Fronts, 2021
A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy against the ...
Xiu Gu, Zi-Xue Zhang, Min-Ru Jiao, Xin-Yan Peng, Jian-Qi Li, Qing-Wei Zhang   +5 more
doaj   +1 more source

Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation

Pharmaceutical Fronts, 2021
This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with ...
Zi-Yi Huang, Min-Ru Jiao, Xiu Gu, Zi-Ran Zhai, Jian-Qi Li, Qing-Wei Zhang   +5 more
doaj   +1 more source

Pharmacovigilance in the pharmaceutical industry [PDF]

British Journal of Clinical Pharmacology, 1998
Pharmacovigilance has been defined as the process of identifying and responding to drug safety issues [1] and has grown considerably as a discipline over the past 10 to 15 years. An educational survey in 1994 revealed that more than 320 people currently worked in company pharmacovigilance functions in the UK alone [2].
J C, Talbot, B S, Nilsson
openaire   +2 more sources

Chemical Process Development in the Pharmaceutical Industry in Europe—Insights and Perspectives from Industry Scientists [PDF]

Angewandte Chemie - International Edition
Krueger J, Dieskau AP, Hassfeld J, Gries J, Block O, Weinmann H, Kaufmann D, Hildbrand S, Kraft V, Moeckel R, Dehli JR, Scholz U, Nising CF.   +12 more
exaly   +2 more sources

Synthesis and Crystal Structure Analysis of Histone Deacetylase Inhibitor Chidamide

Pharmaceutical Fronts, 2023
Chidamide is the first oral subtype-selective histone deacetylase inhibitor approved in China for the treatment of relapsed and refractory peripheral T cell lymphoma.
Bo Han, Xin-Yan Peng, Yan-Qing Gong, Jia-Liang Zhong, Qing-Wei Zhang   +4 more
doaj   +1 more source

Analyzing Pharmaceutical Industry

National Journal of Physiology, Pharmacy and Pharmacology, 2011
Marketing is a social process manifested on the market. Rather than in an isolated vacuum, organizations operate in a complex dynamic environment. Organizations’ efforts are aimed at using business opportunities and averting (or neutralizing ...
Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman   +2 more
doaj   +1 more source

A quantitative method for determination of colistin E2 methanesulphonate in human plasma by 15N-labeled colistin E2

Scientific Reports, 2023
The single-component colistin E2, with superior antibacterial activity and lower toxicity, was being developed as the latest generation of polymyxin drugs. However, colistin E2 has not been tested quantitatively in biological matrices.
Hongjiang Xu, Yanan Li, Jing Zhang, Jinhua Zhang, Jianguang Lu, Xiquan Zhang, Ling Yang, Wenjie Zhao, Jun Feng   +8 more
doaj   +1 more source