Results 41 to 50 of about 3,606,854 (303)

Design, Synthesis, and Evaluation of Benzoheterocyclic-Containing Derivatives as Novel HDAC1 Inhibitors

Pharmaceutical Fronts, 2022
In this study, the synthesis and biological evaluation of a variety of benzoheterocyclic-containing benzamide derivatives were described. Some of these compounds were proved to inhibiting the activity of histone deacetylase 1 (HDAC1) with IC50 values ...
Min-Ru Jiao, Bo Han, Xiu Gu, Hao Zhang, Ai-Ping Wang, Qing-Wei Zhang   +5 more
doaj   +1 more source

Biomarkers in the Pharmaceutical Industry [PDF]

Clinical Chemistry, 2015
Although biomarkers have been the essence of laboratory medicine since its inception, they are relatively new tools in the development of pharmaceutical compounds. The main utility of biomarkers for pharmaceutical companies has been in making drug development a more efficient and a cost-effective process.
Omar F, Laterza, Andrew, Plump, Jeffrey E, Ming, Susan, Richards, Michael E Ransom, Burczynski, John A, Wagner, Scott D, Patterson   +6 more
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Draft genome sequence and annotation of the enfumafungin producing fungus Hormonema carpetanum ATCC 74360

BMC Genomic Data
Objectives Plant endophytic fungusHormonema carpetanum is the only organism known to produce enfumafungin to date. Enfumafungin is a fernane-type triterpenoid glycoside compound with broad-spectrum antifungal activity, and this leading compound has been ...
Haodong Chen, Junyi Wang, Songbai Yang, Jiawei Tang, Wen Tang, Shaoxin Chen   +5 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Recent Advances in Novel Modulators for Cardiac Myosin Disorders

Pharmaceutical Fronts
In advanced stages of heart disease, most cases are characterized by heart failure, where the heart's systolic and diastolic functions are weakened, and then it cannot meet the body's normal oxygen demands.
Hancheng Wang, Mengfei Wang, Bo Han, Qiushi Chen, Qingwei Zhang   +4 more
doaj   +1 more source

Medicine and the Pharmaceutical Industry [PDF]

European Neurology, 2002
Accessible online at: www.karger.com/journals/ene Throughout Europe, institutions providing independent research on efficacy, safety and costs of drugs and therapies are on the retreat: research at universities is increasingly impaired by administrative burdens, lack of funding and staff demoralisation.
openaire   +2 more sources

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Evaluation of incentives for R&D in the pharmaceutical industry with applications for neglected diseases [PDF]

, 2011
PhDThis thesis is concerned with the development of incentives for pharmaceutical R&D, specifically for neglected diseases. The following approaches are adopted.
Trushin, Eshref
core   +4 more sources