Results 61 to 70 of about 571,368 (308)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Drivers of organizational creativity [PDF]

open access: yes, 2005
A path model of organizational creativity was presented; it conceptualized the influences of information sharing, learning culture, motivation, and networking on creative climate.
Dimenäs, Elof   +3 more
core  

Reviewing the Drivers and Challenges in RFID Implementation in the Pharmaceutical Supply Chain [PDF]

open access: yes, 2009
Counterfeiting is a global phenomenon that poses a serious financial threat to the pharmaceutical industry and more importantly jeopardizes public safety and security.
Li, Suhong   +2 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Pharmaceutical Industry\u27s Effect on Socioeconomic Development in Sub-Saharan Africa in Relation to Family Planning Accessibility [PDF]

open access: yes, 2019
There is a large unmet need for family planning services in sub-Saharan Africa (Goodkind et al, 2018). Pharmaceutical companies contribute to the accessibility of medications in developing countries (Cottingham & Berer, 2011).
Demarest, Tessa
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Global Pharmaceutical Industry, 2004 [PDF]

open access: yes
This teaching case looks at the development of the ethical pharmaceutical industry. The various forces affecting the discovery, development, production, distribution and marketing of prescription drugs are discussed in terms of their origins and recent ...
Bernardo Batiz-Lazo, k Sarah Holland
core  

Global Competitiveness in Pharmaceuticals: A European Perspective [PDF]

open access: yes, 2000
The report examines the competitive position of the European pharmaceutical companies and industries, and compares them with the pharmaceutical companies and industries in other parts of the world, particularly the US.
Gambardella, Alfonso   +2 more
core  

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani   +8 more
wiley   +1 more source

La industria farmacéutica granadina durante el franquismo (19361975)

open access: yesArs Pharmaceutica
Resumen Objetivo: Estudiamos los laboratorios farmacêuticos que estuvieron en funcionamiento en la provincia de Granada durante el franquismo (1936-1975), tanto los creados con anterioridad a la guerra civil, como los establecidos durante este conflicto
Antonio Bueno González   +1 more
doaj   +1 more source

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