Results 81 to 90 of about 3,606,854 (303)

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Decoupling the Size and Loading Effects in Silver Nanoparticles for Efficient Paired Carbon Dioxide and Formaldehyde Electrolysis

Advanced Functional Materials, EarlyView.
We investigate size‐dependent CO selectivity on Ag nanoparticles, where optimized Ag loading achieves nearly 100% Faradaic Efficiency for CO at −100 mA·cm−2. In situ SERS and XPS reveal the crucial role of optimized loading in catalytic performance. The Ag/C catalyst further exhibits bifunctional activity, enabling efficient electrolysis of CO2 and ...
Venkata S. R. K. Tandava, Clara Große, Debabrata Bagchi, Zhenye Zhu, Suptish Ghosh, J. Niklas Hausmann, Carsten Walter, Rosario Suarez Anzorena, Catalina Elena Jimenez, Yasmin Lucero Cobos‐Becerra, Jack C. Q. Fletcher, Tobias Sontheimer, Michael Schwarze, Holger Dau, Matthias Driess, Marcus Bär, Prashanth W. Menezes   +16 more
wiley   +1 more source

Mergers and Acquisitions in the Indian Pharmaceutical Industry: Nature, Structure and Performance [PDF]

This paper tries to address the extent, nature and impact of the recent surge in consolidation strategies especially in the form of mergers and acquisitions followed by the firms in the Indian pharmaceutical industry.
Beena, S
core  

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Globalisation and Its Impact on Competitiveness: the Case of the British and German Pharmaceutical Industry [PDF]

This paper assesses the degree of financial and economic globalisation of British and German pharmaceutical companies during 1990 and 2001 and explores the changing balance between globalisation and national embeddedness.
Jocelyn Probert, Christel Lane
core  

CalVSP: a program for analyzing the molecular surface areas, volumes, and polar surface areas

Journal of Cheminformatics
The molecular volume, surface area, and polar molecular surface area are important descriptors for characterizing and predicting the molecular properties of lead compounds.
Yuzhu Li, Daiju Yang, Qingyi Shi, Weidong Zhang, Qingyan Sun   +4 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Does Public Scientific Research Complement Industry R&D Investment? The Case of NIH Supported Basic and Clinical Research and Pharmaceutical Industry R&D [PDF]

This research investigates the hypothesis that publicly funded scientific research complements private R&D investment in the pharmaceutical industry. New microlevel data on public research investment by the U.S.
Toole, Andrew A.
core  

Optimization of Extended-Release ZL-004 Nanosuspensions for In Vivo Pharmacokinetic Study to Enhance Low Solubility and Compliance

Molecules, 2018
ZL-004, a promising small molecule that increases white blood cell counts, was developed for extended-release nanosuspensions to improve low solubility and compliance of patients. In vivo pharmacokinetic studies of nanosuspensions with different particle
Chengyue Guo, Yanna Chen, Junzhe Zhu, Jiaxin Wang, Ying Xu, Hansen Luan, Hao Wang   +6 more
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source