Results 81 to 90 of about 3,763,386 (260)

Biodegradable 3D‐Printable and Coatable Antifouling Composites for Marine Applications

Advanced Functional Materials, EarlyView.
Marine biofouling damages submerged surfaces and raises greenhouse gas emissions. Biodegradable antifouling biocomposites were developed by hot‐mixing beeswax, Tween 80, and calcium stearate or stearic acid. Adjusting the component ratio enables processing via hot‐pressing, 3D‐printing, or dip‐coating.
Gabriele Corigliano, Lorenzo Ravelli, Martina Nardi, Ruowen Tu, Elena Bellini, Valerio Isa, Carlo Filippeschi, Roberta Finazzi, Luca Ceseracciu, Niloofar Paknezhad, Vincenzo Scribano, Paolo Galli, Silvia Lavorano, Simone Montano, Barbara Mazzolai, Marco Contardi, Pietro Cataldi, Athanassia Athanassiou   +17 more
wiley   +1 more source

ACTIVE SUBSTANCES FOR DOMESTIC MANUFACTURER OF MEDICINES: PAST, PRESENT AND FUTURE

Разработка и регистрация лекарственных средств, 2019
At present, there is a tendency in Russia to switch domestic manufacturers of drugs from the system of purchases of chemical products to own production of active pharmaceutical ingredients.
K. O. Sidorov, A. A. Lin, N. V. Marchenko   +2 more
doaj  

Scaffold hopping for discovery of N, N-dibenzylcinnamamide (DBCA) derivatives as novel allosteric GSK-3β inhibitors: Design, synthesis and anti-inflammatory evaluation

Results in Chemistry
Glycogen synthase kinase-3β (GSK-3β) has been identified to promote inflammation and its inhibitors have also been proven to treat some inflammatory-mediated diseases in animal models.
Xinyi Zhang, Weiwei Zhao, Feilong Wang, Wei Zhao, Liang Hu, Zhendong Xie, Xueyan Zhu, Peng Zhang, Yong Chu   +8 more
doaj   +1 more source

Early Academis Science and the Birth of Industrial Research Laboratories in the U.S. Pharmaceutical Industry [PDF]

The establishment and growth of industrial research laboratories is one of the key organizational innovations affecting technological progress in the United States in the 20th century.
Megan MacGarvie, Jeffrey L. Furman
core  

3D‐Printed Gradient Shape‐Memory Strain Sensors With Rewritable Gauge Factors

Advanced Functional Materials, EarlyView.
A 3D‐printed shape‐memory strain sensor combines thermomechanical programming with gradient architectural design. Preset strain rewrites the gauge factor (GF), while the gradient geometry amplifies the response through strain redistribution. Reprogrammable sensitivity enables the same sensor to detect weak pulse signals and monitor large‐amplitude ...
Xuan Zhang, Wenjie Qiao, Kaixin Jiang, Sherry Chen, Hanyu Cui, Kirsten Dyer, Xuefeng Zhu, Ting Wang, Xuehua Zhang, Ben Bin Xu, Jie Kong   +10 more
wiley   +1 more source

Modeling metastasis and predicting drug response with malignant effusion-derived organoids: a systematic review and quantitative assessment

Journal of Translational Medicine
Background Malignant effusions provide a critical window into metastatic biology. Malignant effusion-derived organoids (ME-PDTOs) hold promise for modeling metastasis and predicting drug response, but the evidence remains fragmented.
Jingyu Peng, Shuting Tian, Li Liu, Yifang Deng   +3 more
doaj   +1 more source

Has the European Union Achieved a Single Pharmaceutical Market? [PDF]

This paper explores price differences in the European Union (EU) pharmaceutical market, the EU's fifth largest industry. With the aim of enhancing quality of life along with industry competitiveness and R&D capability, many EU directives have been ...
Gabriel Picone, Aysegul Timur, Jeffrey S. DeSimone   +2 more
core  

Bio‐Inspired Multifunctional Superhydrophilic Coatings With Remarkably Fast Self‐Healing Abilities

Advanced Functional Materials, EarlyView.
We developed bio‐inspired multifunctional hydrogel‐based coatings that exhibit extremely fast/repeatable self‐healing abilities, long‐lasting anti‐fogging performance, superhydrophilicity in air, and underwater superoleophobicity. By doping multivalent metal‐ions into the hydrogel networks, which promoted hydrogen bonding formation and enhanced the ...
Hyeonjin Kim, Jerred Wassgren, Hiroshi Kakiuchida, Kouki Akaike, Shunsuke Tanaka, Atsushi Hozumi   +5 more
wiley   +1 more source

Design and Synthesis of Novel β-catenin/BCL9 Protein–Protein Interaction Small Molecule Inhibitors for the Treatment of Colorectal Cancer

Pharmaceutical Fronts
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. The development of novel targeted drug therapeutics against CRC has been a research hotspot.
Yuyan Long, Mengfei Wang, Qingwei Zhang
doaj   +1 more source

Longitudinal Study on the Performance of U.S. Pharmaceutical Firms: The Increasing Role of Marketing [PDF]

Nowadays, the U.S. pharmaceutical industry has been under thorough scrutiny. Popular press claims of intensive marketing activities that go beyond R&D, the strong increase of me-too drugs, and, at the same time, the high industry profitability have ...
Pattikawa, L.H.
core