Results 101 to 110 of about 223,855 (315)

Evaluation of incentives for R&D in the pharmaceutical industry with applications for neglected diseases [PDF]

open access: yes, 2011
PhDThis thesis is concerned with the development of incentives for pharmaceutical R&D, specifically for neglected diseases. The following approaches are adopted.
Trushin, Eshref
core  

Design and Synthesis of Novel β-catenin/BCL9 Protein–Protein Interaction Small Molecule Inhibitors for the Treatment of Colorectal Cancer

open access: yesPharmaceutical Fronts
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. The development of novel targeted drug therapeutics against CRC has been a research hotspot.
Yuyan Long, Mengfei Wang, Qingwei Zhang
doaj   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

open access: yesAdvanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He   +9 more
wiley   +1 more source

Strategic Development Trends in the World Pharmaceutical Industry [PDF]

open access: yes
The main purpose of the paper is to research and evaluate the strategic development trends in the world pharmaceutical industry in the period 1996–2006.We aim to find that mergers and acquisitions prevail as a vital strategic development option in the ...
Dragan Kesic
core  

The Pharmaceutical Industry in Australia [PDF]

open access: yes, 2007
This paper is concerned with describing and explaining some key structural characteristics of Australian pharmaceutical markets and their associated supply chains.
Sweeny, Kim
core  

Gellan Gum Fluid Gel System for Controlled‐Delivery of Cytokine‐Licensed MSC‐EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency

open access: yesAdvanced Healthcare Materials, EarlyView.
Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh   +7 more
wiley   +1 more source

Market Structure, R&D and Advertising in the Pharmaceutical Industry [PDF]

open access: yes
Recent developments in the literature on market structure have allowed the generation of a few key testable predictions from the theory of strategic behaviour. The seminal model considers one simple but general relationship, that between market structure
Catherine Matraves
core  

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

open access: yesAdvanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano   +11 more
wiley   +1 more source

Internationalising to create Firm Specific Advantages: Leapfrogging strategies of U.S. Pharmaceutical firms in the 1930s and 1940s & Indian Pharmaceutical firms in the 1990s and 2000s [PDF]

open access: yes
Internationalisation is a useful strategy to gain firm specific advantages during periods of technological discontinuity. The pharmaceutical industry offers us two such episodes as examples: when the antibiotics revolution was beginning and when the ...
Athreye, Suma, Godley, Andrew
core  

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

open access: yesAdvanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan   +10 more
wiley   +1 more source

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