Results 21 to 30 of about 222,790 (315)

Quantitative Study of Impurities in Bedaquiline Fumarate: Identification and Characterization of Its Three Degradation Products Using HPLC, LC/ESI-MS, and NMR Analyses

Pharmaceutical Fronts, 2023
The study aimed to establish a high-performance liquid chromatography (HPLC) method for the quantitative analysis of the related substances of bedaquiline fumarate. Nuclear magnetic resonance and mass spectrometry were used for characterization and assay.
Xiao-Wen Zhang, Gang-Long Jiang, Guo-Jing Li, Xiao-Yan Chen, Ai-Nan Zhou, Yu Liu   +5 more
doaj   +1 more source

Extending Viability of Bifidobacterium longum in Chitosan-Coated Alginate Microcapsules Using Emulsification and Internal Gelation Encapsulation Technology

Frontiers in Microbiology, 2019
Bifidobacteria are considered one of the most important intestinal probiotics because of their significant health impact. However, this ability is usually limited by gastrointestinal fluid and temperature sensitivity. Emulsification and internal gelation
Rui Ji, Rui Ji, Jiahui Wu, Jiahui Wu, Junliang Zhang, Junliang Zhang, Tao Wang, Tao Wang, Xudong Zhang, Xudong Zhang, Lei Shao, Daijie Chen, Jian Wang, Jian Wang   +13 more
doaj   +1 more source

Identification, Characterization and Quantification of Process-Related and Degradation Impurities in Lisdexamfetamine Dimesylate: Identifiction of Two New Compounds

Molecules, 2018
Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid ...
Shenghua Gao, Lili Meng, Chunjie Zhao, Tao Zhang, Pengcheng Qiu, Fuli Zhang   +5 more
doaj   +1 more source

Synthesis and Biological Evaluation of a Series of Novel 1-(3-((6-Fluoropyridin-3-yl)oxy)propyl)piperazines as Dopamine/Serotonin Receptor Agonists

Pharmaceutical Fronts, 2022
Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and ...
Xin-Li Du, Yan-Na Ni, Jiang-Rong Ji, Ze-Hong Wan, Zhi-Jing Hu, Yu-Qiang Ge, Jian-Qi Li, Guan Wang   +7 more
doaj   +1 more source

Preparation and Study on the Single-Crystal Structure of Flurbiprofen–Salicylamide Co-crystal

Pharmaceutical Fronts, 2023
Co-crystals can improve the physicochemical properties of pharmaceutical active ingredients, and thus have great potential in improving drug performance.
Jia-Wei Hou, Yan-Qing Gong, Gang Li, Li-Wen Ma, Hong-Juan Pan, Han-Bin Shan, Jia-Liang Zhong   +6 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Benzoheterocyclic-Containing Derivatives as Novel HDAC1 Inhibitors

Pharmaceutical Fronts, 2022
In this study, the synthesis and biological evaluation of a variety of benzoheterocyclic-containing benzamide derivatives were described. Some of these compounds were proved to inhibiting the activity of histone deacetylase 1 (HDAC1) with IC50 values ...
Min-Ru Jiao, Bo Han, Xiu Gu, Hao Zhang, Ai-Ping Wang, Qing-Wei Zhang   +5 more
doaj   +1 more source

Innovation in the pharmaceutical industry [PDF]

BMJ, 1994
The pharmaceutical industry today is operating in an environment whose main feature is an unprecedented pace of change. In most markets the rising costs of health care are of increasing concern, and the medicines bill is being targeted for savings. New constraints are limiting the medicines that can be used and paid for in the system.
openaire   +2 more sources

Synthesis and Characterization of Process-Related Impurities of Antidiabetic Drug Linagliptin

Molecules, 2016
Linagliptin, a xanthine derivative, is a highly potent, selective, long-acting and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.
Yiwen Huang, Xiaoqing He, Taizhi Wu, Fuli Zhang   +3 more
doaj   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source