Results 101 to 110 of about 31,486 (223)

Quality of life over time after new onset refractory status epilepticus

Epilepsia, EarlyView.
Abstract Objective This study aims to better characterize the long‐term neurological quality of life (QOL) outcomes (using the Neuro‐QOL scale) in survivors of new onset refractory status epilepticus (NORSE), including its subtype febrile infection‐related epilepsy syndrome (FIRES), and provide guidance for psychological and social support strategies ...
Matthew D. Gruen, Margaret T. Gopaul, Anthony D. Jimenez, Ayush Batra, Leah J. Blank, Charlotte Damien, Gregory S. Day, Krista Eschbach, Elizabeth E. Gerard, Teneille E. Gofton, Stephen T. Hantus, Nathalie Jette, Amy Jongeling, Peter Kang, Karnig Kazazian, Marissa Kellogg, Minjee Kim, Bahar Madani, Mikaela Morales, Vineet Punia, Claude Steriade, Aaron Struck, Olga Taraschenko, Nathan Torcida, Mark S. Wainwright, Ji Yeoun Yoo, Nicolas Gaspard, Nora Wong, Lawrence J. Hirsch, Aurélie Hanin   +29 more
wiley   +1 more source

Pulmonary Hypertension and Other Potentially Fatal Pulmonary Complications in Systemic Juvenile Idiopathic Arthritis [PDF]

, 2012
Objective Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin‐1 (IL‐1) and IL‐6 inhibitors appear to be effective treatments.
Carol A. Wallace, Egla Rabinovich, Elizabeth Kessler, Jennifer E. Weiss, Jordi Antón, Karen Onel, Kathryn L. Haroldson, Marilynn Punaro, Melissa M. Hazen, Meredith Riebschleger, Murray H. Passo, Nico Wulffraat, null null, Patricia Woo, Peter R. Blier, Robert M. Rennebohm, Sheila Oliveira, Tzielan Lee, Valeria Gerloni, Yukiko Kimura   +19 more
core   +1 more source

A randomised placebo controlled trial of anakinra for treating pustular psoriasis: statistical analysis plan for stage two of the APRICOT trial [PDF]

, 2020
Suzie Cro, Prakash A. Patel, Juliet N. Barker, David Burden, C.E.M. Griffiths, Helen J. Lachmann, Nick J. Reynolds, Richard B. Warren, Francesca Capon, Catherine Smith, Victoria Cornelius   +10 more
openalex   +1 more source

The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High‐Intensity Interval Training of Individuals With Obesity

Immunology, EarlyView.
This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira, Daniela Alves de Abreu, Amanda de Lima Santos Musto, Luiz Henrique da Silva Nali, Jônatas Bussador do Amaral, André Luis Lacerda Bachi, Marina Tiemi Shio, Paula Rezende‐Teixeira, Carolina Nunes França   +8 more
wiley   +1 more source

Successfully Overcoming Allergy to Anakinra Through Intravenous Desensitization in a Child “Case Report”

Case Reports in Immunology
Anakinra, a recombinant interleukin-1 (IL-1) receptor antagonist, is effective in treating autoinflammatory conditions in children; however, it may elicit a hypersensitive reaction, thus requiring desensitization.
Tariq Al Farsi
doaj   +1 more source

Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial Ischemia/Reperfusion Injury

The Scientific World Journal, 2012
Background. Revascularization of infarcted myocardium results in release of inflammatory cytokines mediating myocardial reperfusion injury and heart failure. Blockage of inflammatory pathways dampens myocardial injury and reduces infarct size.
Christina Grothusen, Angelika Hagemann, Tim Attmann, Jan Braesen, Ole Broch, Jochen Cremer, Jan Schoettler   +6 more
doaj   +1 more source

Development of an R script for simple lipidomic and metabolomic data analysis [PDF]

, 2020
Background: Metabolomic and lipidomic studies generate vast quantities of data that are often analysed in a closed software environment with little to no access to the underlying algorithms.
Alshammari, Suad, Alsultan, Monther, Contaifer, Daniel, Morriss, Joshua M., Wijesinghe, Dayanjan S.   +4 more
core   +1 more source

IL-1β inhibition in cardiovascular complications associated to diabetes mellitus [PDF]

, 2017
Diabetes mellitus (DM) is a chronic disease that affects nowadays millions of people worldwide. In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all diagnosed cases of diabetes.
Carraro, Raffaele, Lorenzo, Óscar, Peiró, Concepción, Sánchez-Ferrer, Carlos F.   +3 more
core   +2 more sources

Evidence‐Based and Consensus‐Based Approach to the Treatment of Hidradenitis Suppurativa: Based on the Updated European SK2 Guidelines for the Treatment of Hidradenitis Suppurativa/Acne Inversa

JEADV Clinical Practice, EarlyView.
Wayne P. Gulliver
wiley   +1 more source

Successful Treatment of Severe Purpura Fulminans With Anakinra

Pediatric Dermatology, EarlyView.
ABSTRACT Purpura fulminans (PF) is a rare, often fatal pediatric condition characterized by intravascular thrombosis and hemorrhagic infarction of the skin. A timely diagnosis and treatment are paramount to prevent the involvement of internal organs, causing disseminated intravascular coagulation and gangrene of the extremities.
Francesco Zulian, Luca Spiezia, Antonio Amabile, Francesca Tirelli, Alessandra Meneghel   +4 more
wiley   +1 more source