Results 111 to 120 of about 35,970 (259)

The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review

Cardiology Research and Practice, 2016
Recurrent pericarditis is a complication of acute pericarditis in 20–30% of the patients and is usually idiopathic in nature. The underlying pathogenesis of this condition remains unclear, although immune-mediated mechanisms seem likely.
Shankar Baskar, Allan L. Klein, Andrew Zeft   +2 more
doaj   +1 more source

Intravenous Anakinra for Macrophage Activation Syndrome May Hold Lessons for Treatment of Cytokine Storm in the Setting of Coronavirus Disease 2019

ACR Open Rheumatology, 2020
Macrophage activation syndrome (MAS) and hemophagocytic lymphohistiocytosis (HLH) are increasingly recognized as being on a continuum of cytokine storm syndromes, with different initiating pathways culminating in cytotoxic dysfunction and uncontrolled ...
Theresa L. Wampler Muskardin
doaj   +1 more source

Failure of anti Interleukin-1 β monoclonal antibody in the treatment of recurrent pericarditis in two children

Pediatric Rheumatology Online Journal, 2020
Background Recurrent pericarditis (RP) is a complication (15–30%) of acute pericarditis with an unknown etiology. Treatment regimen consists of a combination of non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, with the addition of ...
Sara Signa, Matteo D’Alessandro, Rita Consolini, Angela Miniaci, Marta Bustaffa, Chiara Longo, Maria A. Tosca, Martina Bizzi, Roberta Caorsi, Leonardo Oliveira Mendonça, Andrea Pession, Angelo Ravelli, Marco Gattorno   +12 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Anakinra usage in febrile infection related epilepsy syndrome: an international cohort

Annals of Clinical and Translational Neurology, 2020
Febrile‐infection related epilepsy syndrome (FIRES) is a devastating neurological condition characterized by a febrile illness preceding new onset refractory status epilepticus (NORSE).
Y. Lai, E. Muscal, Elizabeth M. Wells, N. Shukla, K. Eschbach, Ki Hyeong Lee, M. Kaliakatsos, Nevedita Desai, R. Wickström, M. Viri, E. Freri, T. Granata, S. Nangia, R. Dilena, A. Brunklaus, M. Wainwright, M. Gorman, Coral M. Stredny, A. Asiri, K. Hundallah, A. Doja, E. Payne, E. Wirrell, S. Koh, J. Carpenter, J. Riviello   +25 more
semanticscholar   +1 more source

Hepatotoxicity due to tocilizumab and anakinra in rheumatoid arthritis: two case reports

International Journal of General Medicine, 2011
Mahmud Mahamid1,3, Kalman Paz3, Rifaat Safadi1,21Liver Unit, Holy Family Hospital, Nazareth, Israel; 2Hadassah Medical Center, 3Shaare Zedek Medical Center, Jerusalem, IsraelAbstract: Elevation of liver enzymes in patients with rheumatoid arthritis ...
Mahamid M, Paz K, Safadi R
doaj  

Subcutaneous anakinra in the management of refractory MIS-C in France

Frontiers in Pediatrics
IntroductionMultisystemic inflammatory syndrome in children (MIS-C) is a therapeutic emergency and can lead to myocardial dysfunction (17%–75%) and heart failure (52%–53%).
Perrine Dusser, Alexandre Belot, Fanny Bajolle, Charlotte Kevorkian-Verguet, Ulrich Meinzer, Ulrich Meinzer, Frédéric Huet, Soizic Tiriau, Isabelle Kone-paut   +8 more
doaj   +1 more source

A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis.

PLoS ONE, 2019
Focal and Segmental Glomerulosclerosis (FSGS) is a severe glomerulopathy that frequently leads to end stage renal disease. Only a subset of patients responds to current therapies, making it important to identify alternative therapeutic options.
Michael Boehm, Eva Nora Bukosza, Nicole Huttary, Rebecca Herzog, Christoph Aufricht, Klaus Kratochwill, Christoph A Gebeshuber   +6 more
doaj   +1 more source

Biologic treatments in rheumatoid arthritis and juvenile idiopathic arthritis [PDF]

, 2006
A number of biological approaches to the management of inflammtory arthropathies have been explored. These include the development of IL-1 receptor antagonists and TNF antagonists. Four biological agents are currently marketed in Europe.
Borg, Andrew A.
core  

Successfully Overcoming Allergy to Anakinra Through Intravenous Desensitization in a Child “Case Report”

Case Reports in Immunology
Anakinra, a recombinant interleukin-1 (IL-1) receptor antagonist, is effective in treating autoinflammatory conditions in children; however, it may elicit a hypersensitive reaction, thus requiring desensitization.
Tariq Al Farsi
doaj   +1 more source