Results 141 to 150 of about 31,861 (267)
Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan +7 more
wiley +1 more source
Immunology, Volume 178, Issue 1, Page 109-117, May 2026.This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira +8 more
wiley +1 more source
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. [PDF]
, 2015 BACKGROUND: To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation.
Interleukin 1 Genetics Consortium
core
Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence
Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
Gabriele Mortari +9 more
wiley +1 more source
Author Correction: Anakinra in Sanfilippo syndrome: a phase 1/2 trial [PDF]
Lynda E. Polgreen +9 more
openalex +1 more source
Anakinra Drug Retention Rate and Predictive Factors of Long-Term Response in Systemic Juvenile Idiopathic Arthritis and Adult Onset Still Disease [PDF]
, 2019 Jurgen Sota +32 more
openalex +1 more source
The efficacy of anakinra compared to standard care of treatment for COVID-19: a metaanalysis
, 2022 HAMNA MALIK +5 more
openalex +2 more sources