Results 61 to 70 of about 27,150 (219)

Gout and NLRP3 inflammasome biology

Arthritis &Rheumatology, Accepted Article.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Respons Klinis Pemberian Tocilizumab Dibandingkan Anakinra dalam Tata Laksana Artritis Idiopatik Juvenil Sistemik

Sari Pediatri, 2022
Latar belakang. Artritis idiopatik juvenil (AIJ) sistemik merupakan penyakit inflamasi sistemik yang tidak hanya melibatkan sendi tetapi juga keterlibatan sistemik dan merupakan tipe terberat dari AIJ.
Edy Novery, Rizqi Amalia, Dina Muktiarti, Nia Kurniati   +3 more
doaj   +1 more source

Cerebral autoinflammatory disease treated with anakinra [PDF]

Annals of Clinical and Translational Neurology, 2018
AbstractInterest in autoimmune encephalitis has been growing since the discovery of various autoimmune antibodies, such as N‐methyl D‐aspartate receptors antibody and leucine‐rich glioma‐inactivated 1 antibody. However, in contrast to autoimmune encephalitis associated with dysregulated adaptive immunity in the brain, the question of whether innate ...
Yoonhyuk Jang, Kyung Ah Woo, Soon‐Tae Lee, Sung‐Hye Park, Kon Chu, Sang Kun Lee   +5 more
openaire   +3 more sources

Innate Lymphoid Cell phenotypic and functional alterations in systemic Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Systemic juvenile idiopathic arthritis (sJIA) is a chronic childhood disease classically attributed to innate immune cell dysregulation. This study aimed to elucidate the role of innate lymphoid cells (ILCs), including natural killer (NK) cells and helper‐ILCs (hILCs), in sJIA during clinically inactive disease (CID) through phenotypic and ...
Linda Quatrini, Cecilia Ciancaglini, Ivan Caiello, Silvia Santopolo, Manuela Pardeo, Valentina Matteo, Elena Loricchio, Donato Amodio, Elena Morrocchi, Giulio Olivieri, Paolo Palma, Antonella Insalaco, Marco Francesco Natale, Arianna de Matteis, Nicola Tumino, Claudia Bracaglia, Paola Vacca, Lorenzo Moretta, Fabrizio De Benedetti, Giusi Prencipe   +19 more
wiley   +1 more source

Impact of Interleukin‐1 Blockade on the Development of Macrophage Activation Syndrome in Still's Disease: Incidence and Diagnostic Validity of the EULAR/ACR/PRINTO 2016 MAS Classification Criteria

Arthritis &Rheumatology, Accepted Article.
Objective To evaluate the applicability of the 2016 EULAR/ACR/PRINTO macrophage activation syndrome (MAS) classification criteria in patients with Still's disease (sJIA‐SD) treated with IL‐1‐targeted therapy and to assess the incidence of MAS in this context.
Remco G.A. Erkens, Greta Rogani, Laura Huber, Anouk Verwoerd, Dieneke Schonenberg‐Meinema, J. Merlijn van den Berg, Wineke Armbrust, G. Elizabeth Legger, Sylvia Kamphuis, Ellen J.H. Schatorjé, Esther P.A.H. Hoppenreijs, Joost F. Swart, Marc H.A. Jansen, Jorg van Loosdregt, Sebastiaan J. Vastert   +14 more
wiley   +1 more source

Anakinra Pilot – a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants

Frontiers in Immunology, 2022
BackgroundBronchopulmonary dysplasia (BPD), its complication pulmonary hypertension (BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in infants born extremely prematurely.
Elys A. Green, Elys A. Green, Elys A. Green, David Metz, David Metz, David Metz, Robert Galinsky, Rebecka Atkinson, Rebecka Atkinson, Elizbeth M. Skuza, Megan Clark, Megan Clark, Alistair J Gunn, Carl M. Kirkpatrick, Rod W. Hunt, Rod W. Hunt, Rod W. Hunt, Philip J. Berger, Claudia A. Nold-Petry, Claudia A. Nold-Petry, Marcel F. Nold, Marcel F. Nold, Marcel F. Nold   +22 more
doaj   +1 more source

Reimann's "Habitual Hyperthermia" Responding to Hormone Therapy. [PDF]

, 2016
A 25-year-old woman presented with fever of unknown origin, exhibiting malaise and low-grade fevers in evenings. These fevers exhibited a pattern of starting mid-menstrual cycle with resolution around the onset of menses, matching a pattern of "habitual ...
Currier, Judith S, Yang, Otto O
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis

Open Heart
Aim Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies.
Allan L Klein, Antonio Abbate, Massimo Imazio, George Lazaros, Antonio Brucato, Luca Cantarini, Marco Merlo, Gianfranco Sinagra, Alessandro Andreis, Valentino Collini, Maria De Martino, Marzia De Biasio, Miriam Isola, Nicole Croatto, Veronica Lepre   +14 more
doaj   +1 more source

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Abraham, Abs, Akin, Aronica, Aronica, Ashraf, Auvin, Bar-Klein, Basler, Bhala, Bozzi, Cacheaux, Cerri, Citraro, Dianzani, Diaz-Hernandez, Dityatev, Drion, Engel, Fabene, Friedman, Fu, Fukasawa, Galanopoulou, Ganesh, Gorter, Groettrup, Groettrup, He, Heinemann, Henshall, Holtman, Huang, Iori, Iyer, Jiang, Jimenez-Pacheco, Jimenez-Pacheco, Jung, Kim, Kim, Kwon, Liang, Liepe, Louboutin, Louboutin, Marchi, Maroso, Maroso, Marusich, McRae, Mishto, Mishto, Mishto, Mishto, Mishto, Noe, Nomura, O'Neill, Podojil, Polascheck, Pollock, Prabowo, Quan, Ravizza, Ravizza, Rojas, Rojas, Rojas, Rojas, Roseti, Roseti, Ruden, Sadowski, Scheppingen, Scheppingen, Serrano, Takenouchi, Thalhammer, Varvel, Vezzani, Vezzani, Vezzani, Vezzani, Vezzani, Vliet, Vliet, Volonte, Vries, Wei, Zanker, Zeng, Zhang   +92 more
core   +4 more sources