Results 81 to 90 of about 31,486 (223)

Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience

Medicina
Familial Mediterranean Fever (FMF) is characterized by recurrent febrile attacks and serositis. While colchicine is the primary treatment for FMF, some patients present resistance or intolerance with respect to this drug.
Tuğba Ocak, Havva Nur Köse, Burcu Yağız, Belkıs Nihan Coşkun, Ediz Dalkılıç, Yavuz Pehlivan   +5 more
doaj   +1 more source

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Comparison of the effects of erythropoietin and anakinra on functional recovery and gene expression in a traumatic brain injury model

Frontiers in Pharmacology, 2013
The goal of this study was to compare the effects of two inflammatory modulators, erythropoietin (EPO) and anakinra, on functional recovery and brain gene expression following a cortical contusion impact (CCI) injury.
Gail D Anderson, Todd ePeterson, Cole eVonder Haar, Fred M Farin, Theo K Bammler, Eric D Kantor, James W MacDonald, Michael R Hoane   +7 more
doaj   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis.

PLoS ONE, 2019
Focal and Segmental Glomerulosclerosis (FSGS) is a severe glomerulopathy that frequently leads to end stage renal disease. Only a subset of patients responds to current therapies, making it important to identify alternative therapeutic options.
Michael Boehm, Eva Nora Bukosza, Nicole Huttary, Rebecca Herzog, Christoph Aufricht, Klaus Kratochwill, Christoph A Gebeshuber   +6 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Single-center experience using anakinra for steroid-refractory immune effector cell-associated neurotoxicity syndrome (ICANS) [PDF]

, 2022
Marc Wehrli, Kathleen Gallagher, Yi‐Bin Chen, Mark B. Leick, Steven L. McAfee, Areej El‐Jawahri, Zachariah DeFilipp, Nora Horick, Paul V. O’Donnell, Thomas R. Spitzer, Bimal Dey, Daniella Cook, Michael Trailor, Kevin Lindell, Marcela V. Maus, Matthew J. Frigault   +15 more
openalex   +1 more source

Hepatotoxicity due to tocilizumab and anakinra in rheumatoid arthritis: two case reports

International Journal of General Medicine, 2011
Mahmud Mahamid1,3, Kalman Paz3, Rifaat Safadi1,21Liver Unit, Holy Family Hospital, Nazareth, Israel; 2Hadassah Medical Center, 3Shaare Zedek Medical Center, Jerusalem, IsraelAbstract: Elevation of liver enzymes in patients with rheumatoid arthritis ...
Mahamid M, Paz K, Safadi R
doaj  

Subcutaneous anakinra in the management of refractory MIS-C in France

Frontiers in Pediatrics
IntroductionMultisystemic inflammatory syndrome in children (MIS-C) is a therapeutic emergency and can lead to myocardial dysfunction (17%–75%) and heart failure (52%–53%).
Perrine Dusser, Alexandre Belot, Fanny Bajolle, Charlotte Kevorkian-Verguet, Ulrich Meinzer, Ulrich Meinzer, Frédéric Huet, Soizic Tiriau, Isabelle Kone-paut   +8 more
doaj   +1 more source