Results 51 to 60 of about 101,184 (301)

Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumors [PDF]

, 2016
Anal cancer is a rare type of digestive tract disease, which has had a crescent incidence in a number of regions. Carcinomas are most frequently found, with squamous cell carcinoma (SCC) comprising similar to 95% of all anal tumors. The major risk factor
Bidinotto, Lucas Tadeu, França, Alessandra Paulino Santos de, Levi, José Eduardo, Loaiza, Edgar Antonio Alemán, Longatto, Adhemar, Lorenzi, Adriana Tarla, Oliveira, Cristina Mendes de, Reis, R. M., Rosa, Luciana Albina Reis, Scapulatempo-Neto, Cristovam, Veo, Carlos A. R.   +10 more
core   +1 more source

Impact of Tumor Location on the Efficacy of Lateral and Mesenteric Lymph Node Dissection in Patients With Rectal Cancer Treated by Upfront Surgery

Annals of Gastroenterological Surgery, EarlyView.
This study examined the impact of tumor location on lymph node metastasis (LNM) patterns and the efficacy of lymph node dissection in rectal cancer. Analyzing 882 patients who underwent total mesorectal excision with lateral lymph node dissection, we found that mesenteric LNM rates were higher in tumors located more orally, whereas lateral LNM rates ...
Tomofumi Uotani, Hiroshi Nagata, Yasuyuki Takamizawa, Konosuke Moritani, Shunsuke Tsukamoto, Tsutomu Fujii, Yukihide Kanemitsu   +6 more
wiley   +1 more source

Anal and Perianal Masses: The Common, the Uncommon, and the Rare

Indian Journal of Radiology and Imaging
A variety of tumors involve the anal canal because the anal canal forms the transition between the digestive system and the skin, and this anatomical region is made of a variety of different cells and tissues.
Antony Augustine, Rijo Issac, Aisha Lakhani, Harsha Veena Kanamathareddy, Reetu John, Betty Simon, Dipti Masih, Anu Eapen, Anuradha Chandramohan   +8 more
doaj   +1 more source

Successful Treatment of Metastatic Anal Canal Adenocarcinoma with mFOLFOX6 + Bevacizumab

Case Reports in Oncology, 2016
Anal canal adenocarcinoma is a relatively rare malignancy without established diagnostic and treatment criteria. Case reports of chemotherapy for anal canal adenocarcinoma with distant metastasis are limited, and there is no convincing evidence for ...
Mototsugu Matsunaga, Keisuke Miwa, Yosuke Oka, Sachiko Nagasu, Takahiko Sakaue, Masaru Fukahori, Tomoyuki Ushijima, Yoshito Akagi   +7 more
doaj   +1 more source

Phenotypic Characterization of Seven Pediatric Patients Diagnosed With KAT6B‐Related Disorders: Case Series and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genitopatellar syndrome (GPS) and Say‐Barber‐Biesecker‐Young‐Simpson Syndrome (SBBYSS) are clinically distinct neurodevelopmental disorders caused by monoallelic pathogenic variants in KAT6B. In some cases, GPS and SBBYSS features can overlap, determining an intermediate phenotype.
Vittorio Maglione, Antonio Pizzuti, Gioia Mastromoro, Eleonora Cresta, Paola Favata, Maria Cristina Digilio, Rossella Capolino, Maria Lisa Dentici, Lorenzo Sinibaldi, Antonio Novelli, Marco Tartaglia, Gianluca Terrin, Viviana Cardilli   +12 more
wiley   +1 more source

A Population‐Based Study of Limb Body Wall Complex With Proposed Features for Prenatal Diagnosis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Limb body wall complex (LBWC) is a lethal condition comprising major congenital anomalies. Although currently diagnosed in the early prenatal period, historical diagnostic criteria are based on detailed pathological assessments. Prenatal and postnatal findings of LBWC and their phenotypic overlap with body stalk anomaly (BSA) and recurrent ...
Mary Ann Thomas, Susan Crawford, Tanya Bedard   +2 more
wiley   +1 more source

Value of conventional cytology in the presence of macroscopic lesions of the anal canal

Journal of Coloproctology, 2014
Objectives: To verify the value of conventional cytology for the diagnosis of macroscopic le- sions of the anal canal and to describe the limitations of the samples.
Lêda Pereira de Barcellos, Fábio Russomano, José Ricardo Hildebrandt Coutinho   +2 more
doaj  

Haemorrhoids [PDF]

, 2016
Clinical information monographHaemorrhoids are vascular-rich connective tissue cushions located within the anal canal. Internal haemorrhoids lie proximal to the dentate line in the anal canal, whereas external haemorrhoids are located distal to the ...
Steele, RJC, THAHA, MA
core  

Usefulness of 3D transperineal ultrasound in severe stenosis of the anal canal : preliminary experience in four cases [PDF]

, 2014
Background Organic or functional anal canal stenoses are uncommon conditions that occur in the majority of cases as a consequence of anal diseases. A proper assessment is fundamental for decision making; however, proctological examination and endoanal ...
Kołodziejczyk, M., Santoro, G.A., Sudoł-Szopińska, I., Szopiński, Tomasz, Słapa, R. Z.   +4 more
core   +1 more source

Genotype–Phenotype Correlations, Mortality, and Clinical Insights in Keratitis–Ichthyosis–Deafness Syndrome: A Comprehensive Review and Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Keratosis–ichthyosis–deafness (KID) syndrome is a rare autosomal dominant ectodermal disease caused by mutations in the GJB2 gene, which encodes the gap junction protein Connexin 26 (Cx26) located on Chr. 13q12.11. This study presents the first mortality analysis associated with KID syndrome, focusing on a case report of a Latin American ...
Leslie Patrón‐Romero, Marco Antonio Hernández Lepe, José de Jesús Manríquez Torres, Diego Daniel Aguirre‐Gómez, Natsuo Hayashi‐Mercado, Genaro Rodríguez Uribe, Tadeo Cerón, María Ruiz‐Gamboa, Jesús Alonso Gándara‐Mireles, Ismael Lares‐Asseff, Verónica Loera‐Castañeda, Jorge Alvelais‐Palacios, Lucrecia Arzamendi‐Cepeda, Lidia Magdalena Castañeda‐González, Adolfo García‐Barrón, Francisco Yamal Quiroz Herrera, Francisco González‐Salazar, Horacio Almanza‐Reyes   +17 more
wiley   +1 more source