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Surgical Oncology Clinics of North America, 2017
Anal canal cancer is rather an uncommon disease but its incidence is increasing. Squamous cell carcinoma (SCC) is the most frequent primary anal neoplasm and can encompass a variety of morphologies. HPV infection has a key role in precancerous lesions and cancer development by the production of E6 and E7 oncoproteins. Anal squamous precancerous lesions
Paulo M, Hoff +2 more
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Anal canal cancer is rather an uncommon disease but its incidence is increasing. Squamous cell carcinoma (SCC) is the most frequent primary anal neoplasm and can encompass a variety of morphologies. HPV infection has a key role in precancerous lesions and cancer development by the production of E6 and E7 oncoproteins. Anal squamous precancerous lesions
Paulo M, Hoff +2 more
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Surgical Oncology Clinics of North America
Anal cancer is by itself a rare entity. Even rarer are the uncommon anal tumors described in this article. Diagnosis of these lesions can be challenging as some of these have no symptoms in their initial stages and only cause symptoms once they have progressed to advanced stages. Further, it can be difficult for even the trained eye to make a diagnosis
Paola A, Cruz-Ramos +2 more
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Anal cancer is by itself a rare entity. Even rarer are the uncommon anal tumors described in this article. Diagnosis of these lesions can be challenging as some of these have no symptoms in their initial stages and only cause symptoms once they have progressed to advanced stages. Further, it can be difficult for even the trained eye to make a diagnosis
Paola A, Cruz-Ramos +2 more
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Benign Anal Lesions and the Risk of Anal Cancer
New England Journal of Medicine, 1994Benign anal lesions are often considered to cause a predisposition to anal cancer. To reexamine this association, we linked national data on hospital discharge and cancer in Denmark.After making certain exclusions, we used the Danish Central Hospital Discharge Register to identify 68,549 patients hospitalized with benign anal lesions between 1977 and ...
FRISCH, M +3 more
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Pathophysiology of Anal Cancer
Surgical Oncology Clinics of North AmericaThe pathophysiology of the development of anal cancer is thought to be linked to chronic inflammation, a possible consequence of infections with human papillomavirus (HPV) or HIV, or inflammation from inflammatory bowel disease. Anal HPV-induced carcinogenesis bears similarities to its cervical counterpart via viral integration into the host genome and
Taja, Lozar, Evie, Carchman
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International Journal of Radiation Oncology*Biology*Physics, 1989
Radiation therapy, used either as a single modality or combined with cytotoxic chemotherapy, is now widely accepted as the preferred initial treatment for epidermoid cancers which arise in the anal canal. Such treatment produces high cure rates and permits many patients to retain anorectal function.
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Radiation therapy, used either as a single modality or combined with cytotoxic chemotherapy, is now widely accepted as the preferred initial treatment for epidermoid cancers which arise in the anal canal. Such treatment produces high cure rates and permits many patients to retain anorectal function.
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[Anal dysplasia and anal cancer].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2020Anal intraepithelial neoplasia (AIN) and 89-100% of anal cancers are caused by persistent infections with high-risk (HR) human papillomaviruses (HPV). In HIV-positive patients, anal HPV infection and AIN are very common and these patients have a greatly increased risk of developing anal cancer.
Ulrike, Wieland +2 more
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Current treatment and future directions in the management of anal cancer
Ca-A Cancer Journal for Clinicians, 2022Leila T Tchelebi +2 more
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