Results 101 to 110 of about 190,992 (201)

Mesenchymal Stem Cells Alleviate Crohn's Disease by Regulating CBS‐Mediated Ferroptosis

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
MSCs alleviate CD by regulating CBS‐mediated ferroptosis. Bioinformatics analysis identified CBS as a hub gene shared by CD and ferroptosis. In TNBS‐induced colitis mice, MSCs treatment alleviated intestinal inflammation by upregulating CBS expression, increasing GSH and GPX4 levels, and inhibiting ferroptosis.
Zhixi Huang, Xiaofang Xu, Zhou Huang, Bing Han, Dan Jiang, Xiaodan Lv, Ziqian Huang, Guangfu Lin, Fengxiang Huang, Yu Li, Lichun Han, Deyi Chen, Jianing Lin, Xiaoping Lv   +13 more
wiley   +1 more source

Urethral injury during vaginal delivery: Incidence, management and long‐term outcomes

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1559-1566, September 2026.
Abstract Objective This study examines the incidence, obstetric risk factors, surgical management, and long‐term outcomes of obstetric‐associated urethral injuries during vaginal deliveries. Methods A retrospective case series was conducted at a single, tertiary university‐affiliated medical center between January 2018 and December 2023.
Yoav Baruch, Ronen Gold, Yariv Stabholz, Michael Lavie, Yariv Yogev, Asnat Groutz   +5 more
wiley   +1 more source

Indicators of Suboptimal Treatment Among Patients With Crohn's Disease Treated With Ustekinumab or Risankizumab and Treatment Journey Among Ustekinumab Discontinuers in the United States

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background and Aims Patients with Crohn's disease (CD) may experience suboptimal response to advanced therapies (ATs), including interleukin (IL)‐12/23 inhibitor ustekinumab and IL‐23 inhibitor risankizumab. In an evolving treatment landscape, this study evaluated indicators of suboptimal treatment with these agents. Methods This retrospective
Freddy Caldera, Maryia Zhdanava, Sumesh Kachroo, Lilian Diaz, Aditi Shah, Fengyi Jiang, Caroline Kerner, Dominic Pilon, Jennifer Seminerio   +8 more
wiley   +1 more source

Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review

JCC Plus, Volume 1, Issue 5, September 2026.
This expert opinion offers a practical framework for refractory and difficult‐to‐treat IBD: confirm inflammation objectively, distinguish pharmacologic from structural and functional disease, and then escalate. Across ten clinical questions, the evidence is often limited to case series, and the resulting statements are identified as expert opinion ...
Filiz Akyuz, Oguz Kagan Bakkaloglu, Nalan Gulsen Unal, Ismail Hakki Kalkan, Mehmet Arhan, Ibrahim Hatemi, Taylan Kav, Murat Toruner, Hale Akpinar, Ahmet Tezel, Aykut Ferhat Celik   +10 more
wiley   +1 more source

Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula

Advanced Science
Anal fistula is a common disease with recurrent inflammation and accumulated exudate. Traditional treatments often fail to effectively eliminate inflammation and ensure adequate drainage, leading to prolonged healing time and a high recurrence rate ...
Runxian Wang, Pengwei Ma, Siqi He, Xiao Wang, Jinquan Zhang, Junwen Ye, Mingli Su, Xingxing Shi, Ruoxu Dou   +8 more
doaj   +1 more source

Foreign body ingestions in children and adolescents: A position paper of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) endoscopy special interest group

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 3, Page 539-554, September 2026.
Abstract Foreign body (FB) ingestion is a relatively frequent occurrence in the pediatric population with multiple potential sequelae. Appropriate intervention may range from urgent endoscopic retrieval to watchful waiting, with multiple variables influencing the decision.
Oren Ledder, Raoul Furlano, Alexandra Papadopoulou, Dominique Schluckebier, Andreia Nita, Christos Tzivinikos, Salvatore Oliva, Simona Faraci, Luigi Dall'oglio, Marco Deganello Saccomani, Priya Narula, Iva Hojsak, Jorge Amil Dias, Vasiliki Spyropoulou, Lorenzo Norsa, Gokhan Baysoy, Claudio Romano, Matjaž Homan, Mike Thomson   +18 more
wiley   +1 more source

Study on postoperative anal function in high anal fistula guided by the “tissue preservation and defect minimization” concept

结直肠肛门外科
[Objectives] To explore the correlation between postoperative anal morphology, anal function, and anorectal pressure in patients with high anal fistula, and to demonstrate the effectiveness and validity of applying the “tissue preservation and defect ...
Li Yin, Lin Chenhan, Shi Rong, Chen Zuqing   +3 more
doaj   +1 more source

Durable Cancer Control and Extended Long‐Term Survival Following Salvage Surgery for Squamous Cell Carcinoma of the Anal Canal: A Cohort Study

Journal of Surgical Oncology, Volume 134, Issue 4, Page 604-612, September 15, 2026.
ABSTRACT Aim Salvage surgery is the standard‐of‐care for patients with squamous cell carcinoma of the anal canal (SCCa) who experience isolated locoregional failure after upfront chemoradiotherapy. While perioperative morbidity and short‐term survival outcomes have been described, long‐term outcomes of surgical salvage are unknown.
Paul Savage, David P. Cyr, Dan E. Schiller, Bernard J. Cummings, Alexandra M. Easson, Andrew J. Smith, Carol J. Swallow   +6 more
wiley   +1 more source

Clinical efficacy observation of 4 MHz radiofrequency ablation system in the treatment of anal fistula

[Objectives] To observe the clinical efficacy of 4 MHz radiofrequency ablation system in the treatment of anal fistula. [Methods] Sixty patients with intersphincteric or transsphincteric anal fistula who were admitted to the Anorectal Department of ...
Zhou Hao, Zhang Haoyue, Yuan Jiafu, Zhang Yang, Wang Yehuang, Zhu Huiting   +5 more
core   +1 more source

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source