Results 81 to 90 of about 388,819 (310)

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson   +1 more
wiley   +1 more source

Research status of sphincter-sparing surgery in the treatment of anal fistula

open access: yes结直肠肛门外科
In the treatment of anal fistula, sphincter-sparing surgery can help reduce or avoid damage to the anal sphincter, while maintaining the integrity of the anal anatomical structure and protecting the anal function to the greatest extent possible. However,
Chen Fujun   +3 more
doaj   +1 more source

High-Flow Vascular Malformations in Children. [PDF]

open access: yes, 2020
Children can have a variety of intracranial vascular anomalies ranging from small and incidental with no clinical consequences to complex lesions that can cause substantial neurologic deficits, heart failure, or profoundly affect development. In contrast
Abla, Adib A   +8 more
core  

Further steps of hepatic stimulatory substance purification [PDF]

open access: yes, 1991
The hepatic stimulatory substance (HSS) extracted from weanling rat livers was purified 381,000-fold using chromatographic techniques including nondissociating polyacrylamide gel electrophoresis (nondenaturing PAGE).
Barone, M   +5 more
core   +1 more source

Cancer in Anal Fistulas

open access: yesClinics in Colon and Rectal Surgery, 2023
AbstractFistula-associated anal cancer in Crohn's disease (CD) can be challenging to diagnose and treat. Patients with longstanding fistulas in the setting of CD who present with a sudden change in their symptoms should undergo biopsy under anesthesia with extensive sampling, followed by staging imaging.
Perez, Sean, Eisenstein, Samuel
openaire   +4 more sources

Video-Assisted Anal Fistula Treatment for complex anal fistula: a long-term follow-up study.

open access: yesColorectal Disease, 2020
AIM This prospective study aimed to evaluate the safety and efficacy of Video-Assisted Anal Fistula Treatment (VAAFT) in complex Fistula-In-Ano (FIA).
G. Giarratano   +3 more
semanticscholar   +1 more source

A contribution to the anatomy of two rare cetacean species: The hourglass dolphin (Cephalorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica)

open access: yesThe Anatomical Record, EarlyView.
Abstract The anatomical description of the hourglass dolphin (Cephalorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica) remains largely unexplored, due to limited specimen availability and preservation challenges. This study employed digital imaging techniques, conventional histology, and computed tomography to provide visualization of
Jean‐Marie Graïc   +26 more
wiley   +1 more source

Long‐term outcome of the Surgisis® (Biodesign®) anal fistula plug for complex cryptoglandular and Crohn’s fistulas

open access: yesColorectal Disease, 2020
To evaluate the long‐term success rate of treatment with the Surgisis® (Biodesign®) anal fistula plug for complex anal fistulas, assess fistula plug failure over time and compare success rates for fistula plug between a group of patients with ...
Ursula Aho Fält   +4 more
semanticscholar   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza   +4 more
wiley   +1 more source

Crohn's disease: is there any link between anal and luminal phenotypes?

open access: yes, 2015
International audiencePURPOSE: Perianal Crohn's disease (CD) encompasses a variety of lesion similar to luminal disease, which are usually not distinctly assessed.
Bouguen, Guillaume   +4 more
core   +3 more sources

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