Results 91 to 100 of about 118,646 (279)

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

Acupuncture for cancer pain in adults. [PDF]

, 2011
BACKGROUND: Forty percent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief.
Akhileswaran, Alimi, Alimi, Aung, Bardia, Beuken-van Everdingen, Beuken-van Everdingen, Brainin-Mattos, Carr, Cata, Chen, Chen, Coleman, Dang, Dang, Dang, Davis, Derry, Dillon, Ernst, Ernst, Ezzo, Filshie, Filshie, Filshie, Furlan, Goudas, Gralow, Green, Guo, He, Higgins, Hopwood, Jadad, Johnson, Keskinbora, Kwon, Laird, Lee, Lipton, Lund, Lundeberg, Lundeberg, MacPherson, Manheimer, Manheimer, Mao-Ying, Mao-Ying, Mehling, Meng, Minton, Nguyen, Payne, Petrut, Poulain, Qaseem, Ripamonti, Rosier, Sima, Strong, Sun, Trinh, Twycross, Urch, Vallerand, White, White, White, Xia, Yu, Zhang   +70 more
core   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

MANAGEMENT OF ACUTE PAIN IN PATIENT WITH PATIENT-CONTROLLED ANALGESIA

e-Jurnal Medika Udayana, 2013
Acute and chronic pain each has its own challenges because these patients are often dependent on opioids and have many psychosocial factors. None of these methods of pain control are superior than others.
Siska Permanasari Sinardja, IGN Mahaalit Aribawa   +1 more
doaj  

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Post-thoracotomy pain relief with subpleural analgesia or thoracic epidural analgesia: randomized clinical trial

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Post-thoracotomy pain is a severe and intense pain caused by trauma to ribs, muscles and peripheral nerves. The current study aimed to compare subpleural analgesia (SPA) with thoracic epidural analgesia (TEA) in patients ...
Aysu Hayriye Tezcan, Özgür Karakurt, Mehmet Ali Eryazgan, Semih Başkan, Dilşen Hatice Örnek, Ramazan Baldemir, Bülent Koçer, Mustafa Baydar   +7 more
doaj   +1 more source

Local anaesthesia efficacy as postoperative analgesia for open shoulder instability surgery. a prospective randomised controlled study [PDF]

, 2012
Background and objectives: The aim of present study was to evaluate for the first time, the clinical effect of local anaesthetic infiltration as postoperative analgesia in open shoulder surgery for anterior-inferior instability.
Caricati Alessio, Costantini Alberto, De Vita Andrea, Di Donato A, Fontana Costantino, Lancia Fabrizio, Rocco Monica   +6 more
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Patient-Controlled Oral Analgesia for Postoperative Pain Management Following Total Knee Replacement

Pain Research and Management, 2010
PURPOSE: To investigate whether patient-controlled oral analgesia (PCOA) used by individuals receiving a total knee replacement could reduce pain, increase patient satisfaction, reduce opioid use and/or reduce opioid side effects when compared with ...
Patti Kastanias, Sue Gowans, Paul S Tumber, Kianda Snaith, Sandra Robinson   +4 more
doaj   +1 more source

Post-Pancreatoduodenectomy Outcomes and Epidural Analgesia: A 5-Year Single Institution Experience [PDF]

, 2019
Introduction Optimal pain control post-pancreatoduodenectomy is a challenge. Epidural analgesia (EDA) is increasingly utilized despite inherent risks and unclear effects on outcomes.
Ceppa, Eugene P., Colgate, Cameron L., Fennerty, Mitchell L., House, Michael G., Kilbane, E. Molly, Nakeeb, Attila, Schmidt, C. Max, Simpson, Rachel E., Zyromski, Nicholas J.   +8 more
core   +1 more source