Results 111 to 120 of about 219,594 (315)
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
In situ structure and assembly of the ABC-type tripartite pump MacAB-TolC
Communications BiologyThe MacAB-TolC tripartite efflux pump is widely distributed in Gram-negative bacteria, extruding antibiotics and virulence factors that lead to multidrug resistance and pathogenicity.
Tong Huo +9 more
doaj +1 more source
An Atypical Case of Taravana Syndrome in a Breath-Hold Underwater Fishing Champion: A Case Report
Case Reports in Medicine, 2013 Dysbaric accidents are usually referred to compressed air-supplied diving. Nonetheless, some cases of decompression illness are known to have occurred among breath-hold (BH) divers also, and they are reported in the medical literature.
Andrea Cortegiani +6 more
doaj +1 more source
Advanced Science, EarlyView.A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li +14 more
wiley +1 more source
AGING MEDICINE, EarlyView.This study investigates the regulatory effects of lactulose and polyethylene glycol (PEG) on the composition of gut microbiota in elderly constipation patients with chronic renal insufficiency by comparing the changes in microbial abundance. Both lactulose and PEG significantly modulate the gut microbiota structure, though their specific mechanisms and
Jianxia Ma +10 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.This study demonstrates that combining the NCD Risk Calculator with the mFI‐5 enables more precise stratification of postoperative delirium risk in patients undergoing surgery for HCC. Patients classified as high risk by the combined model showed a markedly higher incidence of delirium than those in the intermediate‐ and low‐risk groups.
Kiyotaka Hosoda +9 more
wiley +1 more source
Preventive analgesia for postoperative pain control: a broader concept
, 2014 Nalini Vadivelu,1 Sukanya Mitra,2 Erika Schermer,3 Vijay Kodumudi,4 Alan David Kaye,5 Richard D Urman61Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Anesthesia and Intensive Care, Government Medical ...
Kaye AD +5 more
core
Primary Spoken Language and Neuraxial Labor Analgesia Use Among Hispanic Medicaid Recipients
, 2016 Hispanic women are less likely than non-Hispanic Caucasian women to use neuraxial labor analgesia. It is unknown whether there is a disparity in anticipated or actual use of neuraxial labor analgesia among Hispanic women based on primary language ...
Feinglass, Joe +4 more
core +1 more source