Results 171 to 180 of about 402,046 (367)

Microgel Aspect Ratio Influences Injectable Granular Hydrogel Scaffold Pore Structure and Cellular Invasion for Tissue Repair

open access: yesAdvanced Science, EarlyView.
Granular hydrogels are being developed for the repair of tissues, mostly with the use of spherical microgels. Here, injectable granular hydrogels formed from anisotropic particles (i.e., rod‐like) are explored to improve cellular invasion by increasing scaffold void volume fraction.
Gabriel J. Rodriguez‐Rivera   +11 more
wiley   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu   +11 more
wiley   +1 more source

Bioengineered Skin Grafts from Patient‐Derived Decellularized Extracellular Matrix and Autologous Cells for Personalized Regenerative

open access: yesAdvanced Science, EarlyView.
This study presents a patient‐specific skin model using autologous cells, decellularized dermal ECM, and keratin–alginate bioinks. The model supports cell compatibility, collagen deposition, and epidermal differentiation within a biomimetic ECM environment.
RaeHui Kang   +10 more
wiley   +1 more source

Índice de colapsabilidad de la vena cava inferior como predictor de hipotensión intraoperatoria

open access: yesRevista Chilena de Anestesia, 2019
María   +5 more
doaj   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

open access: yesAdvanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang   +28 more
wiley   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao   +11 more
wiley   +1 more source

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