Results 61 to 70 of about 410,347 (354)

A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep

Nature Communications, 2023
A comorbidity of chronic pain is sleep disturbance. Here, we identify a dual-functional ensemble that regulates both pain-like behaviour induced by chronic constrictive injury or complete Freund’s adjuvant, and sleep wakefulness, in the nucleus accumbens
Haiyan Sun, Zhilin Li, Zhentong Qiu, Yu Shen, Qingchen Guo, Su-Wan Hu, Hai-Lei Ding, Shuming An, Jun-Li Cao   +8 more
doaj   +1 more source

Labor Analgesia as a Predictor for Reduced Postpartum Depression Scores: A Retrospective Observational Study

Anesthesia and Analgesia, 2017
BACKGROUND: Using labor, epidural analgesia has been linked to a reduced risk of postpartum depression, but the role of labor pain relief in this association remains unclear.
Grace Lim, Lia M. Farrell, F. Facco, M. Gold, A. Wasan   +4 more
semanticscholar   +1 more source

Analgesia in Obstetrics [PDF]

Geburtshilfe und Frauenheilkunde, 2012
Background: An effective relief of labour pain has become an important part of obstetric medicine. Therefore regional nerve blocks, systemic analgesic and non-pharmacologic techniques are commonly used. This review article gives a summary of pathophysiology and anatomy of labour pain as well as advantages, disadvantages, risks and adverse reactions of ...
M, Heesen, M, Veeser
openaire   +2 more sources

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Agreement of Doppler Ultrasound and Visual Sphygmomanometer Needle Oscillation with Invasive Blood Pressure in Anaesthetised Dogs

Animals
Visual sphygmomanometer needle oscillation (SNO) can occur before audible return of pulsatile flow (ARPF) when measuring blood pressure by Doppler ultrasound.
Marc Armour, Joanne Michou, Imogen Schofield, Karla Borland   +3 more
doaj   +1 more source

Analgesia, and the International Anesthesia Research Society

, 2022
The past century has seen significant advances in the practice of obstetric anesthesiology. This article will review the role of Anesthesia & Analgesia and the International Anesthesia Research Society in contributing to fundamental paradigm shifts in ...
Paloma Toledo, Cynthia A. Wong, Wong, Cynthia A, Toledo, Paloma   +3 more
core   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The Eye as a Window to Neurodegeneration: Oxidative Stress, Optic Nerve Vulnerability, and Retinal Biomarkers—A Scoping Review

Antioxidants
Neurodegenerative diseases represent a major and growing global health burden characterized by progressive neuronal dysfunction, axonal degeneration, and irreversible neural tissue loss.
Giustino Varrassi, Y Van Tran, Giacomo Farì, Miguel Narvaez Encinas, Alberto Corriero, Filomena Puntillo, Phong Van Pham, Matteo Luigi Giuseppe Leoni   +7 more
doaj   +1 more source

Combination of Opioid Agonist and Agonist-Antagonist: Patient-Controlled Analgesia Requirement and Adverse Events among Different-Ratio Morphine and Nalbuphine Admixtures for Postoperative Pain

, 2011
BACKGROUND: Nalbuphine, a mixed agonist-antagonist opioid, has a potential to attenuate the mu-opioid effects and to enhance the kappa- opioid effects.
YEH, YU-CHANG;LIN, TZU-FU;LIN, FENG-SHENG;WANG, YONG-PING;LIN, CHEN-JUNG;SUN, WEI-ZEN, 葉育彰;林子富;林峰盛;王永彬;林珍榮;孫維仁   +1 more
core   +1 more source