Results 181 to 190 of about 19,751 (211)

Tazadolene: A centrally‐acting, non‐narcotic analgesic

Drug Development Research, 1988
AbstractIntravenous tazadolene elevated the threshold stimulus for rabbits to respond to electrical tooth‐pulp stimulation. Systemic tazadolene also increased the latency for mice to lick their paws in the hot‐plate analgesic test. However, tazadolene did not alter the mouse tail flick, a spinal reflex most sensitive to analgesics acting at spinal ...
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Impact of non-narcotic oral analgesics on pain management

The American Journal of Medicine, 1988
Of the four categories of oral analgesics, three have been available since the 19th century. Although adequate doses of the more potent oral opioids such as morphine and methadone are effective even in severe pain, the commonly used "weak" narcotics such as codeine and propoxyphene are no more effective than usual doses of aspirin or acetaminophen ...
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[Mode of action of non-narcotic analgesics].

Revue du rhumatisme et des maladies osteo-articulaires, 1992
According to Lim's experiments, non-narcotic analgesics are usually considered as "peripherally" acting drugs. Conversely, most of these compounds were shown to easily cross the blood-brain barrier, and hence partly produce their effects by a central mechanism. The relative contribution of each site of action may vary from one drug to another.
B, Bannwarth, A, Chaslerie, T, Schaeverbeke, G, Vinçon, J, Dehais, B, Begaud   +5 more
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Promising non-narcotic analgesic techniques for labour.

Bailliere's clinical obstetrics and gynaecology, 1999
Epidural analgesia and spinal analgesia are the most effective techniques for relieving labour pain. Basically, local anaesthetics (i.e. bupivacaine) and opioids (i.e. fentanyl or sufentanil), especially when combined, produce excellent analgesia with minimal motor blockade.
F J, Mercier, D, Benhamou
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The toxicology of non-narcotic analgesics.

Agents and actions. Supplements, 1986
The fact that aminopyrine is readily nitrosated and that the nitrosation product, dimethylnitrosamine, is potentially carcinogenic has led to the drug being withdrawn from therapeutic use. In the case of the other analgesics, nitrosation is not of any importance, neither in toxicological nor quantitative terms.
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Liver damage with non-narcotic analgesics.

Medical toxicology, 1987
Non-narcotic analgesics can produce a variety of hepatic lesions but clinically significant liver damage is uncommon with normal therapeutic use. The pattern of hepatotoxicity caused by the salicylates, non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen) and the pyrazolones differs but many of these drugs can cause generalised ...
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Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics.

Archives internationales de pharmacodynamie et de therapie, 1976
Using a food-reinforced two-lever operant procedure, rats (n=6) were trained to discriminate fentanyl (1.25 mg/kg, p.o., t-60') from solvent (1 ml/100 g B.W., p.o., t-60'). The administration of another narcotic analgesic (pethidine) produced a dose-related generalization with the standard fentanyl treatment; six non-narcotic analygesics (suprofen ...
F C, Colpaert, C J, Niemegeers, P A, Janssen   +2 more
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Pharmacotherapy I: Non-Narcotic Analgesics

Dental Clinics of North America, 1978
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Hepatotoxicity of non-narcotic analgesics

Journal of Oral and Maxillofacial Surgery, 1999
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Non-Narcotic Analgesics: Use in the Breastfeeding Woman

Journal of Human Lactation, 1989
L L, Moore, L L, Toll
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