Results 181 to 190 of about 51,375 (229)

Haematological Effects of Non-Narcotic Analgesics

Drugs, 1986
By far the largest proportion of side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) belong to the category of so-called PAR (pseudo-allergic reactions). The sensitising potential of a drug is probably connected with its protein-binding capacity.
Peter A. Miescher, Wolfgang Pola
openaire   +4 more sources

Hepatotoxicity of non-narcotic analgesics

The American Journal of Medicine, 1998
The central role of the liver in drug metabolism sets the stage for drug-related hepatotoxicity. The incidence of hepatotoxicity associated with non-narcotic analgesics is low, but their widespread use both prescription and over-the-counter-makes analgesic-associated hepatotoxicity a clinically and economically important problem.
K. G. Tolman
openaire   +4 more sources

Gastrointestinal Intolerance and Bleeding with Non-Narcotic Analgesics

Drugs, 1986
Aspirin and paracetamol (acetaminophen) are the most commonly used minor analgesics, but their effects on the gastrointestinal tract differ widely. The effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), including phenylbutazone, are intermediate.
K. J. Ivey, K. J. Ivey
openaire   +4 more sources

Comparative Safety Evaluation of Non-narcotic Analgesics

Journal of Clinical Epidemiology, 1998
Both spontaneous reports and single outcome studies may distort the overall safety evaluation of drugs. We identified epidemiologic studies, published from January 1970 to December 1995, that investigated the association of serious adverse effects with aspirin, diclofenac, acetaminophen, and dipyrone to determine and compare the excess mortality ...
Andrade, Susan E., Martinez, Carlos, Walker, Alexander M.   +2 more
openaire   +5 more sources

Side Effects of Non-Narcotic Analgesics as a Determinant of Prescribing

Drugs, 1986
In the prescription of non-narcotic analgesics the physician's main responsibility is to make sure that the quality-of-life improvement expected from the drug's use justifies the associated risk, low though it is, of fatal side effects. The range of acceptable risk depends, naturally, on the dosage and duration of the treatment and on those ...
O. Miettinen
openaire   +4 more sources

Impact of non-narcotic oral analgesics on pain management

The American Journal of Medicine, 1988
Of the four categories of oral analgesics, three have been available since the 19th century. Although adequate doses of the more potent oral opioids such as morphine and methadone are effective even in severe pain, the commonly used "weak" narcotics such as codeine and propoxyphene are no more effective than usual doses of aspirin or acetaminophen ...
W. Beaver
openaire   +4 more sources

Effect of Non-narcotic Analgesics on Membrane Permeability of Molluscan Neurones

Nature New Biology, 1972
IT is difficult to study how analgesics act: not only are the pharmacokinetics complex, but assessment of drug activity is subjective. Certain discrepancies occur regarding the analgesic potency of several compounds and also disagreement concerning their site of action1–4. No proposed mechanism of action2,3 is widely accepted.
Jeffery L. Barker, Herbert Levitan
openaire   +4 more sources

Analgesics in Ophthalmic Practice: A Review of the Oral Non-narcotic Agent Tramadol

Optometry and Vision Science, 1999
This report reviews the causes of ocular pain and discusses the pharmacology, pharmacokinetics, efficacy, adverse effects, and dosage of tramadol, a novel non-narcotic oral analgesic. Tramadol is a synthetic analog of codeine with a dual mechanism of action that involves agonist activity at the mu opioid receptor, as well as inhibition of monoaminergic
Robert L. Barkin, Bruce I. Gaynes
openaire   +4 more sources

The Mechanism of Action of the Non-narcotic Analgesics

Medical Clinics of North America, 1968
Frank Guzman, Robert K. S. Lim
openaire   +4 more sources

BLOOD DYSCRASIAS AND THE RELATIVE SAFETY OF NON-NARCOTIC ANALGESICS

The Lancet, 1987
Xavier Carné, Joan-Ramon Laporte
openaire   +4 more sources