Results 161 to 170 of about 10,401,764 (218)

Effects of Non-Narcotic Analgesics on the Liver

Drugs, 1986
Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been reported on occasion with virtually all ...
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Non-Narcotic Analgesics — Their use and Abuse

Journal of The Royal Naval Medical Service, 1972
Abstract There is now available a considerable range of non-narcotic analgesics; many are still supplied in the form of compound tablets although true synergy is rare in clinical pharmacology. The value of these analgesics is discussed and their many other uses outlined.
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Abuse of Non-Narcotic Analgesics

1977
After reports had first been published from Switzerland referring to the abuse of antipyretic analgesics containing phenacetin (Kielholz, 1954; Horrisberger et al., 1958; Battegay, 1958) and to the possibility of a causal connection between such abuse and chronic renal diseases (Spuhler and Zollinger, 1963), numerous authors subsequently drew attention
P. Kielholz, D. Ladewig
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Flunixin meglumine: a non-narcotic analgesic.

The Journal of Pharmacology and Experimental Therapeutics, 1977
The N-methyl-d-glucamine salt of flunixin (flunixin meglumine) is a potent non-narcotic analgesic agent after parenteral administration in mice, rats and monkeys. It is significantly more potent than pentazocine, meperidine and codeine in the rat yeast paw test after subcutaneous administration in saline.
V B, Ciofalo, M B, Latranyi, J B, Patel, R I, Taber   +3 more
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Effects of Non-Narcotic Analgesics on the Kidney

Drugs, 1986
Non-narcotic analgesics have acute and chronic effects on the kidney. Until quite recently chronic effects have received much more attention than acute effects. Renal papillary necrosis attributed to prolonged intake of analgesic compounds was first described from Switzerland in the 1950s, and subsequently in many countries including Scandinavia ...
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Pharmacokinetics of a non-narcotic analgesic, DA-5018, in rats

Biopharmaceutics & Drug Disposition, 1998
The pharmacokinetics of a non-narcotic analgesic, DA-5018, were compared after single intravenous (i.v.), subcutaneous (s.c.), and oral administrations, and after multiple (seven consecutive days) s.c. administration to rats. After i.v. administration of DA-5018, 1, 2, and 5 mg kg-1, the pharmacokinetic parameters of DA-5018 were independent of the ...
J J, Lee, H J, Shim, S H, Kim, S D, Lee, W B, Kim, J, Yang, M G, Lee   +6 more
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Gastrointestinal Intolerance and Bleeding with Non-Narcotic Analgesics

Drugs, 1986
Aspirin and paracetamol (acetaminophen) are the most commonly used minor analgesics, but their effects on the gastrointestinal tract differ widely. The effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), including phenylbutazone, are intermediate.
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Potentiation of a non-narcotic analgesic, dipyrone, by cholinomimetic drugs

Psychopharmacologia, 1972
Dipyrone analgesia in mice was potentiated by physostigmine, neostigmine and pilocarpine. This potentiation was antagonized by atropine sulfate and atropine methyl nitrate. Tremorine and dextroamphetamine which implicate brain monoamines in their analgesic effects, were inactive, as were carbachol and nicotine.
U G, Kamat, R J, Pradhan, U K, Sheth
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Non-Narcotics and Co-Analgesics

1984
Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are the most important of the non-narcotic analgesics. As simple analgesics they have equal potency but paracetamol is generally better tolerated, particularly with regard to gastrointestinal side-effects1.
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Blockade by l-lysine of non-narcotic analgesics.

The Journal of Pharmacology and Experimental Therapeutics, 1980
The antinociceptive effects of the non-narcotic analgesics clonixin, flunixin, acetylsalicylic acid, aminopyrine and phenylbutazone in the yeast paw test were blocked by l-lysine. Blockade occurred at doses of l-lysine which did not affect pain threshold. The site(s) or mechanism of action of blockade could not be determined with certainty.
L C, Iorio, M, Latranyi, E, Heath, A, Barnett   +3 more
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