Results 1 to 10 of about 35,390 (262)
The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review
Brain Sciences, 2021 Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely used clinically for sedation and anesthesia. The role of dexmedetomidine has been an interesting topic of neonatological and anesthetic research since a series of ...
Last Mudenda Zilundu, Rao Fu
exaly +3 more sources
Dexmedetomidine: present and future directions [PDF]
Korean Journal of Anesthesiology, 2019 Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties.
Seongheon Lee
doaj +1 more source
Pakistan Armed Forces Medical Journal, 2023 Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture. Study Design: Quasi-experimental study. Place and Duration
Kaukab Majeed +5 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo +8 more
doaj +1 more source
Intensive Care Medicine Experimental, 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini +12 more
doaj +1 more source
Journal of Cardiothoracic Surgery, 2020 Background The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect.
Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji
doaj +1 more source
Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review [PDF]
Medicinski Glasnik, 2023 Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation ...
Rudy Vitraludyono +2 more
doaj +1 more source
Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats.
PLoS ONE, 2022 PurposeWe examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats.MethodsMale rats (226-301 g, n = 49) under isoflurane anesthesia had their tail vein ...
Yoichiro Kitajima +4 more
doaj +1 more source
Journal of International Medical Research, 2022 Objective We investigated the effect of dexmedetomidine anesthesia on postoperative cognitive function after pulmonary surgery. Methods A blinded, prospective, randomized, placebo-controlled study was performed on 60 patients (age range 65–74 years ...
Tao Liu +9 more
doaj +1 more source
Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats [PDF]
International Neurourology Journal, 2017 Purpose Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults.
Je Hoon Park +9 more
doaj +1 more source