Results 1 to 10 of about 28,483 (230)

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis [PDF]

Advanced science
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Zhang H, Shen J, Zhang H, Gao S, Wang J, Wang Y, Li M, Liu Z, Zhang Y, Li Y, Zhang X.   +10 more
europepmc   +2 more sources

Respiratory Support With Nasal High Flow Reduces Opioid Requirements During Endoscopic Retrograde Cholangiopancreatography. [PDF]

DEN Open
ABSTRACT Objectives Nasal high flow (NHF) improves oxygenation, reduces the work of breathing, and stabilizes ventilation. In endoscopic retrograde cholangiopancreatography (ERCP) under dexmedetomidine‐based sedation, opioids are often required but increase the risk of respiratory depression and delayed recovery.
Mori T, Ayuse T, Sato S, Ichinomia T, Yano R, Shimakura A, Nakao Y, Takahashi K, Fukushima M, Haraguchi M, Sasaki R, Ozawa E, Miuma S, Tatkov S, Hara T, Miyaaki H.   +15 more
europepmc   +2 more sources

Intranasal Dexmedetomidine for Paediatric Procedural Sedation in the Emergency Department: A Single-Centre Retrospective Observational Cohort Study. [PDF]

Emerg Med Australas
ABSTRACT Objectives To describe the use, effectiveness and safety of intranasal dexmedetomidine (IN DEX) for ED paediatric procedural sedation. Method A retrospective cohort study was conducted over 7 months following implementation of an IN DEX guideline at Townsville University Hospital ED.
Whyte E, Emeto TI, Snowden F, Gangathimmaiah V.   +3 more
europepmc   +2 more sources

Dexmedetomidine: present and future directions [PDF]

Korean Journal of Anesthesiology, 2019
Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties.
Seongheon Lee
doaj   +1 more source

Efficacy of Perineural versus Systemic Dexmedetomidine as an Adjuvant to Bupivacaine for Surgical Anesthesia in Axillary Block

Pakistan Armed Forces Medical Journal, 2023
Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture. Study Design: Quasi-experimental study. Place and Duration
Kaukab Majeed, Amran Hafiz, Usman Eijaz Malik, Fayyaz Hussain, Najm Us Saqib, Amna Gulraz   +5 more
doaj   +1 more source

Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke

Intensive Care Medicine Experimental, 2022
Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi, Patricia Rieken Macedo Rocco   +12 more
doaj   +1 more source

Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats [PDF]

International Neurourology Journal, 2017
Purpose Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults.
Je Hoon Park, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Chang Ju Kim, Soo Hwan Yoon, Jongki Hong, Jun Young Chung, Deok Won Lee   +9 more
doaj   +1 more source

Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Frontiers in Aging Neuroscience, 2022
Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo, Long-yan Li, Long-yan Li, Li-zhe Guo, Lu Wang, Yan-feng Wang, Na Chen, E. Wang, E. Wang   +8 more
doaj   +1 more source

Effect of dexmedetomidine on intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic lung lobectomy

Journal of Cardiothoracic Surgery, 2020
Background The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect.
Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji
doaj   +1 more source

Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review [PDF]

Medicinski Glasnik, 2023
Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation ...
Rudy Vitraludyono, Arie Utariani, Elizeus Hanindito   +2 more
doaj   +1 more source