Results 1 to 10 of about 40,767 (276)
BMC Anesthesiology, 2020 Background Sepsis often accompanies gastrointestinal motility disorder that contributes to the development of sepsis in turn. Propofol and dexmedetomidine, as widely used sedatives in patients with sepsis, are likely to depress gastrointestinal ...
Haiqing Chang +9 more
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Real-time evaluation of the independent analgesic efficacy of dexmedetomidine
BMC Anesthesiology, 2023 Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic effect of dexmedetomidine is often masked by the effects of other general anaesthetics.
XiaoHua Wang +6 more
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Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation
Pharmaceuticals, 2021 Dexmedetomidine, an α2-adrenergic receptor agonist, is used as an anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α).
Chen-Fang Lee +9 more
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In Vitro Effect of Dexmedetomidine on Platelet Aggregation
Brazilian Journal of Anesthesiology, 2013 Background and objectives: : Dexmedetomidine is a selective α2-agonist. There are 250-300 α2- adrenoceptor on the surface of each human platelet and ephedrine induces platelet aggregation by binding these receptors.
Emine Arzu Kose +3 more
doaj +1 more source
Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23. [PDF]
PLoS ONE, 2016 To investigate the effects and underlying mechanism of dexmedetomidine on the cultured human dendritic cells (DCs).Human DCs and cytotoxic T lymphocytes (CTLs) were obtained from human cord blood mononuclear cells by density gradient centrifugation ...
Gong Chen +9 more
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Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia
Frontiers in Neuroscience, 2022 Dexmedetomidine, as an α2-adrenoceptor agonist, plays anti-sympathetic, sedative and analgesic roles in perioperative period. Also, dexmedetomidine can reduce the minimal alveolar concentration (MAC) of sevoflurane and the risk of postoperative cognitive
Lei Zhang +15 more
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Frontiers in PharmacologyAimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi +4 more
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Journal of Intensive Care, 2019 Purpose Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking.
Ekaterina R. Yavarovich +4 more
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Patient Safety in Surgery, 2020 Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in ...
Mohammad Reza Fazel +3 more
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Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study [PDF]
Korean Journal of Anesthesiology, 2017 BackgroundDexmedetomidine is a highly selective central α2-agonist used as a sedative in pediatric intensive care unit (PICU). However, little is known about the relationship between dexmedetomidine dose and its plasma concentration during long-term ...
Yoshihito Fujita +6 more
doaj +1 more source