Results 21 to 30 of about 28,483 (230)
Ketamine, Dexmedetomidine combination versus Dexmedetomidine in decreasing Incidence and Severity of Emergence Agitation after Urological Surgeries in Pediatrics under Sevoflurane [PDF]
Zagazig University Medical JournalBackground: Emergence agitation (EA) is a serious complication of recovery from anesthesia. This study aimed to compare the effect of adding ketamine to Dexmedetomidine versus Dexmedetomidine alone in the incidence and severity of EA in pediatric ...
Tarek Jaafer +3 more
doaj +1 more source
Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation
Pharmaceuticals, 2021 Dexmedetomidine, an α2-adrenergic receptor agonist, is used as an anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α).
Chen-Fang Lee +9 more
doaj +1 more source
Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats [PDF]
Anesthesia and Pain Medicine, 2020 Background Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor.
Dong Joon Kim +5 more
doaj +1 more source
In Vitro Effect of Dexmedetomidine on Platelet Aggregation
Brazilian Journal of Anesthesiology, 2013 Background and objectives: : Dexmedetomidine is a selective α2-agonist. There are 250-300 α2- adrenoceptor on the surface of each human platelet and ephedrine induces platelet aggregation by binding these receptors.
Emine Arzu Kose +3 more
doaj +1 more source
BMC Anesthesiology, 2020 Background Sepsis often accompanies gastrointestinal motility disorder that contributes to the development of sepsis in turn. Propofol and dexmedetomidine, as widely used sedatives in patients with sepsis, are likely to depress gastrointestinal ...
Haiqing Chang +9 more
doaj +1 more source
Real-time evaluation of the independent analgesic efficacy of dexmedetomidine
BMC Anesthesiology, 2023 Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic effect of dexmedetomidine is often masked by the effects of other general anaesthetics.
XiaoHua Wang +6 more
doaj +1 more source
Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23. [PDF]
PLoS ONE, 2016 To investigate the effects and underlying mechanism of dexmedetomidine on the cultured human dendritic cells (DCs).Human DCs and cytotoxic T lymphocytes (CTLs) were obtained from human cord blood mononuclear cells by density gradient centrifugation ...
Gong Chen +9 more
doaj +1 more source
Patient Safety in Surgery, 2020 Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in ...
Mohammad Reza Fazel +3 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange +8 more
wiley +1 more source
Frontiers in PharmacologyAimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi +4 more
doaj +1 more source