Results 31 to 40 of about 51,358 (247)
Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation
Pharmaceuticals, 2021 Dexmedetomidine, an α2-adrenergic receptor agonist, is used as an anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α).
Chen-Fang Lee +9 more
doaj +1 more source
Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]
, 2020 Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong +8 more
core
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia
Frontiers in Neuroscience, 2022 Dexmedetomidine, as an α2-adrenoceptor agonist, plays anti-sympathetic, sedative and analgesic roles in perioperative period. Also, dexmedetomidine can reduce the minimal alveolar concentration (MAC) of sevoflurane and the risk of postoperative cognitive
Lei Zhang +15 more
doaj +1 more source
The importance of measuring skin resistance for electrical nociceptive stimulation in standing horses [PDF]
, 2017 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Veterinary Surgery and Anaesthesiology Faculty of Veterinary Medicine and Animal Science UNESP – Univ.
Crosignani, N +5 more
core +2 more sources
Systematic review of the behavioural assessment of pain in cats [PDF]
, 2016 Objectives The objectives were to review systematically the range of assessment tools used in cats to detect the behavioural expression of pain and the evidence of their quality; and to examine behavioural metrics (considering both the sensory and ...
Brondani JT +11 more
core +1 more source
Journal of Intensive Care, 2019 Purpose Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking.
Ekaterina R. Yavarovich +4 more
doaj +1 more source
Aberrant migration and surgical removal of a heartworm (Dirofilaria immitis) from the femoral artery of a cat. [PDF]
, 2018 A cat was evaluated for an acute-onset of right pelvic limb paresis. Thoracic radiographs revealed normal cardiac size and tortuous pulmonary arteries.
Balsa, Ingrid M +8 more
core +1 more source
Frontiers in PharmacologyAimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2016 Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia.
Maiko Hongo +6 more
doaj +1 more source