Results 31 to 40 of about 35,390 (262)

Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study [PDF]

Korean Journal of Anesthesiology, 2017
BackgroundDexmedetomidine is a highly selective central α2-agonist used as a sedative in pediatric intensive care unit (PICU). However, little is known about the relationship between dexmedetomidine dose and its plasma concentration during long-term ...
Yoshihito Fujita, Koichi Inoue, Tasuku Sakamoto, Saya Yoshizawa, Maiko Tomita, Toshimasa Toyo'oka, Kazuya Sobue   +6 more
doaj   +1 more source

Perioperative Low Dose Dexmedetomidine and Its Effect on the Visibility of the Surgical Field for Middle Ear Microsurgery: A Randomised Controlled Trial

Frontiers in Pharmacology, 2022
Background and Purpose: There are many benefits of administering dexmedetomidine perioperatively. The pharmacokinetics (PK) and pharmacodynamics (PD) of intravenous, intranasal and oral dexmedetomidine that was administered before anesthesia were ...
Jinhong Wu, Yuan Han, Yu Lu, Yan Zhuang, Wenxian Li, Ji’e Jia   +5 more
doaj   +1 more source

Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia

Frontiers in Neuroscience, 2022
Dexmedetomidine, as an α2-adrenoceptor agonist, plays anti-sympathetic, sedative and analgesic roles in perioperative period. Also, dexmedetomidine can reduce the minimal alveolar concentration (MAC) of sevoflurane and the risk of postoperative cognitive
Lei Zhang, Lei Zhang, Lei Zhang, Hua Li, Liyun Deng, Kun Fang, Yuanyuan Cao, Yuanyuan Cao, Cheng Huang, Cheng Huang, Cheng Huang, Erwei Gu, Erwei Gu, Jun Li, Jun Li, Jun Li   +15 more
doaj   +1 more source

Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study

Patient Safety in Surgery, 2020
Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in ...
Mohammad Reza Fazel, Zeynab Sadat Ahmadi, Hossein Akbari, Fahimeh Abam   +3 more
doaj   +1 more source

Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation

Pharmaceuticals, 2021
Dexmedetomidine, an α2-adrenergic receptor agonist, is used as an anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α).
Chen-Fang Lee, Chih-Hsien Cheng, Hao-Chien Hung, Jin-Chiao Lee, Yu-Chiao Wang, Tsung-Han Wu, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan, Wei-Chen Lee   +9 more
doaj   +1 more source

Association between dexmedetomidine use for the treatment of alcohol withdrawal syndrome and intensive care unit length of stay

Journal of Intensive Care, 2019
Purpose Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking.
Ekaterina R. Yavarovich, Maythawee Bintvihok, Justin C. McCarty, Janis L. Breeze, Peter LaCamera   +4 more
doaj   +1 more source

Effect of different sedatives on the prognosis of patients with mechanical ventilation: a retrospective cohort study based on MIMIC-IV database

Frontiers in Pharmacology
AimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi, Jiaxing Zhang, Yufei Sun, Meijun Chen, Fei Han   +4 more
doaj   +1 more source

Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.

, 2012
CONTEXT: Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine, an α(2)-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient comfort.
Garrat, C, Dexmedetomidine for long term sedation investigators,, Grounds, RM, Sarapohja, T, Ruokonen, Esko, Takala, Jukka, Sarapohja, Toni, Pocock, Stuart J, Ruokonen, E, Jakob, SM, Grounds, R Michael, Pocock, SJ, Garratt, Chris, Bratty, J Raymond, Dexmedetomidine for Long-Term Sedation Investigators, Jakob, Stephan M, Bratty, JR, Takala, J, LAMBERMONT, Bernard, Dexmedetomidine for Long-Term Sedation, Investigators   +19 more
core   +1 more source

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

Age-related effects of dexmedetomidine on myocardial contraction and coronary circulation in isolated guinea pig hearts

Journal of Pharmacological Sciences, 2016
Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia.
Maiko Hongo, Susumu Fujisawa, Takeshi Adachi, Tomonori Shimbo, Shigehiro Shibata, Takayoshi Ohba, Kyoichi Ono   +6 more
doaj   +1 more source