Results 11 to 20 of about 4,394 (170)
Brazilian Journal of Anesthesiology, 2023 Background: The precise underlying mechanism of antioxidant effects of dexmedetomidine-induced neuroprotection against cerebral ischemia has not yet been fully elucidated.
Yong-Hee Park +6 more
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Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models
Scientific Reports, 2021 Previous studies suggest an impact of dexmedetomidine on cardiac electrophysiology. However, experimental data is sparse. Therefore, purpose of this study was to investigate the influence of dexmedetomidine on different experimental models of ...
Christian Ellermann +9 more
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Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundDexmedetomidine is a highly selective α2-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction ...
Seong-Ho Ok +3 more
doaj +1 more source
BJA Open, 2023 Background: Postoperative acute kidney injury (AKI) is a common complication and is associated with increased hospital length of stay and 30 day all-cause mortality.
Manuel A. Paredes-Flores +10 more
doaj +1 more source
BMC Anesthesiology, 2018 Background There may be great individual variability in the hemodynamic effects of this dexmedetomidine. For this reason, the dose must be carefully adjusted to achieve the desired clinical effect.
Yuan Han +7 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background and Purpose: There are many benefits of administering dexmedetomidine perioperatively. The pharmacokinetics (PK) and pharmacodynamics (PD) of intravenous, intranasal and oral dexmedetomidine that was administered before anesthesia were ...
Jinhong Wu +5 more
doaj +1 more source
Frontiers in Surgery, 2022 BackgroundDexmedetomidine reduces the occurrence of postoperative nausea and vomiting (PONV); however, the effect of dexmedetomidine on PONV in patients undergoing thoracic surgery remains inconclusive.
Wei Zhang +5 more
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Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats [PDF]
Anesthesia and Pain Medicine, 2020 Background Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor.
Dong Joon Kim +5 more
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Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation
Pharmaceuticals, 2021 Dexmedetomidine, an α2-adrenergic receptor agonist, is used as an anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α).
Chen-Fang Lee +9 more
doaj +1 more source
In Vitro Effect of Dexmedetomidine on Platelet Aggregation
Brazilian Journal of Anesthesiology, 2013 Background and objectives: : Dexmedetomidine is a selective α2-agonist. There are 250-300 α2- adrenoceptor on the surface of each human platelet and ephedrine induces platelet aggregation by binding these receptors.
Emine Arzu Kose +3 more
doaj +1 more source