ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis [PDF]
Advanced scienceA low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Zhang H +10 more
europepmc +2 more sources
Dexmedetomidine hydrochloride as a long-term sedative [PDF]
Therapeutics and Clinical Risk Management, 2011 Takayuki KunisawaSurgical Operation Department, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, JapanAbstract: Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory ...
Kunisawa T
doaj +2 more sources
A Novel Application of the Volumetric Absorptive Micro Sampling Strategy to Quantify Dexmedetomidine in Capillary Blood Using an LC-MS/MS Method. [PDF]
J Clin Lab AnalThis study introduces a novel application of MITRA devices for collecting capillary blood to quantify dexmedetomidine using a newly developed and validated LC–MS/MS method. The highly sensitive developed method was successfully applied to analyze patient whole blood samples.
Lucatello L +6 more
europepmc +2 more sources
Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient-Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial. [PDF]
Acta Anaesthesiol ScandABSTRACT Purpose Dexmedetomidine has been studied as an adjunct to opioid patient‐controlled analgesia (PCA) because of its opioid‐sparing properties and limited respiratory depression. However, potential dose‐dependent haemodynamic effects should be considered, and data on dexmedetomidine administered via PCA remain limited.
Mäkelä S +5 more
europepmc +2 more sources
The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review
Brain Sciences, 2021 Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely used clinically for sedation and anesthesia. The role of dexmedetomidine has been an interesting topic of neonatological and anesthetic research since a series of ...
Rao Fu, Prince Lm Zilundu, Xiaoying Xu
exaly +3 more sources
Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures
Therapeutics and Clinical Risk Management, 2010 Mohanad Shukry, Jeffrey A MillerUniversity of Oklahoma Health Sciences Center, Department of Anesthesiology, Children’s Hospital of Oklahoma, Oklahoma City, OK, USAAbstract: Dexmedetomidine was introduced two decades ago as a sedative and ...
Mohanad Shukry, Jeffrey A Miller
doaj +1 more source
Dexmedetomidine Inhibition of GABA Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice [PDF]
Brain BehavGraphical Abstract ABSTRACT Introduction Dexmedetomidine is a sedative anesthetic with a unique ability to produce an arousable state of sedation. However, the neural mechanisms underlying this arousable sedation remain incompletely understood. Previous studies have implicated dopaminergic neurons in the ventral tegmental area (VTA) in mediating this ...
Rao J, Qiu G, Wang J, Li Y.
europepmc +2 more sources
Sedation with dexmedetomidine in the intensive care setting
Open Access Emergency Medicine, 2011 Anthony T Gerlach, Claire V Murphy The Ohio State University Medical Center, Ohio State University, Columbus, OH, USA Abstract: Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive ...
Gerlach AT, Murphy CV
doaj +1 more source
Drug Design, Development and Therapy, 2017 Yanhua Chen,1,* Xu Zhang,2,* Bingdong Zhang,1 Guodong He,2 Lifang Zhou,2 Yubo Xie2 1Department of Anesthesiology, Cardiovascular Institute, 2Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China *These ...
Chen Y +5 more
doaj +1 more source
A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]
, 2013 Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M. +15 more
core +4 more sources