Results 11 to 20 of about 35,390 (262)

Dexmedetomidine hydrochloride as a long-term sedative

open access: yesTherapeutics and Clinical Risk Management, 2011
Takayuki KunisawaSurgical Operation Department, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, JapanAbstract: Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory ...
Kunisawa T
doaj   +4 more sources

Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures

open access: yesTherapeutics and Clinical Risk Management, 2010
Mohanad Shukry, Jeffrey A MillerUniversity of Oklahoma Health Sciences Center, Department of Anesthesiology, Children’s Hospital of Oklahoma, Oklahoma City, OK, USAAbstract: Dexmedetomidine was introduced two decades ago as a sedative and ...
Mohanad Shukry, Jeffrey A Miller
doaj   +1 more source

Sedation with dexmedetomidine in the intensive care setting

open access: yesOpen Access Emergency Medicine, 2011
Anthony T Gerlach, Claire V Murphy The Ohio State University Medical Center, Ohio State University, Columbus, OH, USA Abstract: Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive ...
Gerlach AT, Murphy CV
doaj   +1 more source

Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

open access: yesDrug Design, Development and Therapy, 2017
Yanhua Chen,1,* Xu Zhang,2,* Bingdong Zhang,1 Guodong He,2 Lifang Zhou,2 Yubo Xie2 1Department of Anesthesiology, Cardiovascular Institute, 2Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China *These ...
Chen Y   +5 more
doaj   +1 more source

Sedative Effects of Dexmedetomidine and Ketamine or Dexmedetomidine and Midazolam on Tear Production, Ocular Perfusion Pressure and Pupil Diameter in Rabbits. [PDF]

open access: yesVet Med Sci
Sedative effects of intramuscular injection of dexmedetomidine and ketamine or dexmedetomidine and midazolam on tear production (TP), ocular perfusion pressure (OPP) and pupillary diameter (PD) in two groups of seven male New Zealand rabbits (G1 and G2, respectively).
Mohammadzadeh M   +2 more
europepmc   +2 more sources

Incidence of acute kidney injury after noncardiac surgery in patients receiving intraoperative dexmedetomidine: a retrospective study

open access: yesBJA Open, 2023
Background: Postoperative acute kidney injury (AKI) is a common complication and is associated with increased hospital length of stay and 30 day all-cause mortality.
Manuel A. Paredes-Flores   +10 more
doaj   +1 more source

A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]

open access: yes, 2013
Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M.   +11 more
core   +1 more source

Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models

open access: yesScientific Reports, 2021
Previous studies suggest an impact of dexmedetomidine on cardiac electrophysiology. However, experimental data is sparse. Therefore, purpose of this study was to investigate the influence of dexmedetomidine on different experimental models of ...
Christian Ellermann   +9 more
doaj   +1 more source

The Effect of Dexmedetomidine on Postoperative Nausea and Vomiting in Patients Undergoing Thoracic Surgery-A Meta-Analysis of a Randomized Controlled Trial

open access: yesFrontiers in Surgery, 2022
BackgroundDexmedetomidine reduces the occurrence of postoperative nausea and vomiting (PONV); however, the effect of dexmedetomidine on PONV in patients undergoing thoracic surgery remains inconclusive.
Wei Zhang   +5 more
doaj   +1 more source

Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles. [PDF]

open access: yes, 2022
The goal of this study was to investigate the pharmacokinetic (PK) behaviour of dexmedetomidine in dogs administered as a pure enantiomer versus as part of a racemic mixture. Eight unmedicated intact purpose-bread beagles were included.
Spadavecchia, Claudia   +23 more
core   +1 more source

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