Results 41 to 50 of about 8,624 (186)
Binding Pathway of Opiates to $μ$ Opioid Receptors Revealed by Unsupervised Machine Learning [PDF]
, 2018 Many important analgesics relieve pain by binding to the $\mu$-Opioid Receptor ($\mu$OR), which makes the $\mu$OR among the most clinically relevant proteins of the G Protein Coupled Receptor (GPCR) family. Despite previous studies on the activation pathways of the GPCRs, the mechanism of opiate binding and the selectivity of $\mu$OR are largely ...
arxiv +1 more source
Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]
, 2020 © The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa +3 more
core +1 more source
Transplantation Reports, 2017 The aim of this pilot study was to determine if the use of Ketorolac for donor nephrectomies could decrease the use of narcotics. Methods: This is a prospective, double blind, randomized trial involving patients undergoing nephrectomy for live donor ...
Jeffrey Campsen +4 more
doaj +1 more source
Caffeine Modulates the Dynamics of DODAB Membranes: Role of the Physical State of the Bilayer [PDF]
, 2020 Caffeine (1,3,7-trimethylxanthine), an ingredient of coffee, is used worldwide as a psychostimulant, antioxidant, and adjuvant analgesic. To gain insights into the action mechanism of caffeine, we report on its effects on the phase behaviour and microscopic dynamics of a dioctadecyldimethylammonium bromide (DODAB) lipid membrane, as studied ...
arxiv +1 more source
Journal of Periodontology, EarlyView.Abstract Background The purpose of this randomized, three‐armed clinical trial is to determine if a postoperative injection of 0.5% bupivacaine is more effective than 2% lidocaine in controlling pain after periodontal flap surgery. Methods Seventy‐six patients planned for similar periodontal surgeries were included.
Jessica D. Koster +4 more
wiley +1 more source
Stereotypical escape behavior in Caenorhabditis elegans allows quantification of nociceptive stimuli levels [PDF]
, 2016 Experiments of pain with human subjects are difficult, subjective, and ethically constrained. Since the molecular mechanisms of pain transduction are reasonably conserved among different species, these problems are partially solved by the use of animal models. However, animals cannot easily communicate to us their own pain levels. Thus progress depends
arxiv +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT The use of opioids is frequently associated with the occurrence of adverse effects during cesarean delivery, especially for primiparous women with severe preeclampsia, creating a critical need for investigation of alternative analgesic strategies.
Yong Yang, Ya‐Ni Zhang
wiley +1 more source
Opioid Analgesic Prescribing Practices of Dental Professionals in the United States [PDF]
, 2017 The prescription of opioid analgesics by dental professionals is widespread in the United States. Policy makers, government agencies, and professional organizations consider this phenomenon a growing public health concern.
Okunseri, Christopher +4 more
core +2 more sources
Academic Emergency Medicine, Volume 32, Issue 4, Page 426-433, April 2025.Abstract Background Pain management is a critical part of treatment in patients with chest trauma. Opioids and nonsteroidal anti‐inflammatory drugs have been the most commonly used medications. However, their side effects have drawn attention to other medications.
Hossein Zabihi Mahmoodabadi +4 more
wiley +1 more source
Opioid-free anesthesia for breast cancer surgery: An observational study
Journal of Anaesthesiology Clinical Pharmacology, 2018 Background and Aims: Opioids are associated with postoperative nausea, vomiting, drowsiness, and increased analgesic requirement. A nonopioid anesthesia technique may reduce morbidity, enable day care surgery, and possibly decrease tumor recurrence.
Swagata Tripathy +6 more
doaj +1 more source