Results 51 to 60 of about 11,067 (184)

Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys

Equine Veterinary Journal, Volume 58, Issue 5, Page 1390-1395, September 2026.
Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno, Andressa Nunes Mouta, Larissa de Sant' Ana Alves, Kathryn Nóbrega Arcoverde, Herbert Reis Aragão, Jerson Marques Cavalcante, Valéria Veras de Paula   +6 more
wiley   +1 more source

THE STUDY OF EFFECTS OF THE INTRANASAL DEXMEDETOMIDINE ADMINISTRATION ON PAIN SENSITIVITY

Разработка и регистрация лекарственных средств, 2019
The development of new antinociceptive agents and new approaches to pain relief based on potent non-narcotic analgesics is one of the most in demand and urgent directions of modern pharmacology.
O. I. Rudko, E. A. Klimov, V. V. Sobolev, A. V. Sosnov, K. A. Rufanov, F. M. Semchenko   +5 more
doaj  

Low-molecular synthetic peptides with non-narcotic type of analgesia: comparative study and mechanism of analgesic activity

Molecular Pain, 2019
The group of synthetic low-molecular peptides exhibiting profound analgesic activity was developed by modifying the salmon calcitonin molecule fragment sCT 16-21 , which retains the previously reported analgesic activity of the full-sized molecule.
Arkady M Kotin, Maksim O Emelyanov, Oleg A Kotin   +2 more
doaj   +1 more source

Educational Needs Analysis for Postoperative Early Ambulation Among Surgical‐Ward Nurses and Patients: Using Borich Needs Assessment and Locus for Focus Models

Journal of Clinical Nursing, Volume 35, Issue 9, Page 3845-3856, September 2026.
ABSTRACT Aims and Objectives To identify and prioritize educational needs for early ambulation after abdominal surgery from the perspectives of surgical‐ward nurses and postoperative patients. Background Early ambulation is a core component of enhanced recovery after abdominal surgery, yet educational gaps in nurses' practice and patients ...
Minji Park, Younhee Jeong
wiley   +1 more source

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim‐Sulfamethoxazole Acute Respiratory Distress Syndrome

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Keith Feldman, Jenna O. Miller, Katherine Doane, Laura Loftis, James W. Antoon, Kevin J. Downes, Jennifer L. Goldman   +6 more
wiley   +1 more source

SELECTION CRITERIA OF COMPOUNDS FOR DEVELOPMENT OF HIGH-POTENT ANALGESICS AND OTHER CNS DRUGS

Разработка и регистрация лекарственных средств, 2019
The global opioid crisis requires a paradigm shift in medical use of opioids, the development of methodology to reduce illicit drug use, and development of drug addiction treatment and antidotes.
A. V. Sosnov, F. M. Semchenko, V. N. Tohmahchi, A. A. Sosnova, M. I. Vlasov, A. S. Radilov, D. V. Krivorotov   +6 more
doaj  

SYNERGISM OF THE ANALGESIC ACTIVITY OF METAMIZOLE SODIUM WITH KETAMINE AND DEXMEDETOMIDINE IN MULTIMODAL ANALGESIA IN A MODEL OF ACUTE VISCERAL PAIN

Клінічна та профілактична медицина
Introduction. Multimodal analgesia is a cornerstone of opioid-sparing strategies for acute pain management. Metamizole is a widely used non-opioid analgesic with combined peripheral and central mechanisms; however, its potentiation by central adjuvants ...
Mariia V. Matvieienko, Mykola O. Chyzh, Fedir V. Hladkykh, Olha V. Basarab, Madona O. Gogiya   +4 more
doaj   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, Volume 38, Issue 8, Page 442-452, August 2026.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Mirogabalin for Neuropathic Pain: A Review of Non-Opioid Pharmacotherapy with Insights from Japan

Future Pharmacology
Background and Aim: Neuropathic pain leads to a significant deterioration in health-related quality of life (HRQOL). Treating neuromusculoskeletal pain is especially important to prevent and improve physical frailty and the locomotive syndrome.
Mizuho Sumitani, Takamichi Kogure, Hiroaki Abe, Rikuhei Tsuchida, Reo Inoue, Masahiko Sumitani   +5 more
doaj   +1 more source

COST-EFFECTIVENESS ANALYSIS OF THE USE OF NARCOTIC ANALGESICS IN PATIENTS WITH POST-CAESAREAN SECTION AT A MOTHER AND CHILD HOSPITAL IN PANDEGLANGHILD HOSPITAL IN PANDEGLANG

Jurnal Farmasi Sains dan Praktis
The majority of patients undergoing cesarean section experience moderate to severe pain. To reduce pain after surgery, therapy can be used in the form of administering narcotic analgesics. The selection of the type of narcotic analgesic affects the level
Yusransyah Yusransyah, Sofi Nurmay Stiani, Syilvi Adini Adini, Suci Nurul Fauzi   +3 more
doaj   +1 more source