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Drugs, 1986
The first cases of fulminant hepatic failure due to paracetamol poisoning were reported in 1966, and in the United Kingdom this condition is now responsible for more cases of acute hepatic failure than any other cause. Adults account for the majority of serious and fatal cases of paracetamol poisoning and it is extremely rare for young children to ...
T J, Meredith, J A, Vale
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The first cases of fulminant hepatic failure due to paracetamol poisoning were reported in 1966, and in the United Kingdom this condition is now responsible for more cases of acute hepatic failure than any other cause. Adults account for the majority of serious and fatal cases of paracetamol poisoning and it is extremely rare for young children to ...
T J, Meredith, J A, Vale
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BLOOD DYSCRASIAS AND THE RELATIVE SAFETY OF NON-NARCOTIC ANALGESICS
Lancet, The, 1987Joan-Ramon Laporte +2 more
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Haematological Effects of Non-Narcotic Analgesics
Drugs, 1986By far the largest proportion of side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) belong to the category of so-called PAR (pseudo-allergic reactions). The sensitising potential of a drug is probably connected with its protein-binding capacity.
P A, Miescher, W, Pola
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Use and abuse of non-narcotic analgesics
Drug and Alcohol Dependence, 1978The definition of abuse and dependence of non-narcotic analgesics should take into consideration the interaction of drug and personality. Usually, definitions are based on qualitative aspects of the risk-benefit ratio in the use of psychotropic drugs.
D, Ladewig +4 more
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Hepatotoxicity of non-narcotic analgesics
The American Journal of Medicine, 1998The central role of the liver in drug metabolism sets the stage for drug-related hepatotoxicity. The incidence of hepatotoxicity associated with non-narcotic analgesics is low, but their widespread use both prescription and over-the-counter-makes analgesic-associated hepatotoxicity a clinically and economically important problem.
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Metabolism of the non-narcotic analgesic, Wy-535
Biochemical Pharmacology, 1965Abstract Hexahydro-1,3-dimethyl-4-phenylazepine-4-14C-carboxylic acid, ethyl ester (Wy-535), was administered to dogs and rats both orally and intramuscularly. Tissue levels were determined in the rat, and plasma levels as well as urinary and fecal excretion rates were determined in both species.
S S, WALKENSTEIN +3 more
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Comparative Safety Evaluation of Non-narcotic Analgesics
Journal of Clinical Epidemiology, 1998Both spontaneous reports and single outcome studies may distort the overall safety evaluation of drugs. We identified epidemiologic studies, published from January 1970 to December 1995, that investigated the association of serious adverse effects with aspirin, diclofenac, acetaminophen, and dipyrone to determine and compare the excess mortality ...
Andrade, Susan E. +2 more
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Effects of Non-Narcotic Analgesics on the Liver
Drugs, 1986Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been reported on occasion with virtually all ...
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Abuse of Non-Narcotic Analgesics
1977After reports had first been published from Switzerland referring to the abuse of antipyretic analgesics containing phenacetin (Kielholz, 1954; Horrisberger et al., 1958; Battegay, 1958) and to the possibility of a causal connection between such abuse and chronic renal diseases (Spuhler and Zollinger, 1963), numerous authors subsequently drew attention
P. Kielholz, D. Ladewig
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