Results 81 to 90 of about 10,900 (134)

Non-Narcotic Analgesics — Their use and Abuse

Journal of The Royal Naval Medical Service, 1972
Abstract There is now available a considerable range of non-narcotic analgesics; many are still supplied in the form of compound tablets although true synergy is rare in clinical pharmacology. The value of these analgesics is discussed and their many other uses outlined.
openaire   +2 more sources

Effects of Non-Narcotic Analgesics on the Kidney

Drugs, 1986
Non-narcotic analgesics have acute and chronic effects on the kidney. Until quite recently chronic effects have received much more attention than acute effects. Renal papillary necrosis attributed to prolonged intake of analgesic compounds was first described from Switzerland in the 1950s, and subsequently in many countries including Scandinavia ...
openaire   +2 more sources

Flunixin meglumine: a non-narcotic analgesic.

The Journal of Pharmacology and Experimental Therapeutics, 1977
The N-methyl-d-glucamine salt of flunixin (flunixin meglumine) is a potent non-narcotic analgesic agent after parenteral administration in mice, rats and monkeys. It is significantly more potent than pentazocine, meperidine and codeine in the rat yeast paw test after subcutaneous administration in saline.
V B, Ciofalo, M B, Latranyi, J B, Patel, R I, Taber   +3 more
openaire   +2 more sources

Pharmacokinetics of a non-narcotic analgesic, DA-5018, in rats

Biopharmaceutics & Drug Disposition, 1998
The pharmacokinetics of a non-narcotic analgesic, DA-5018, were compared after single intravenous (i.v.), subcutaneous (s.c.), and oral administrations, and after multiple (seven consecutive days) s.c. administration to rats. After i.v. administration of DA-5018, 1, 2, and 5 mg kg-1, the pharmacokinetic parameters of DA-5018 were independent of the ...
J J, Lee, H J, Shim, S H, Kim, S D, Lee, W B, Kim, J, Yang, M G, Lee   +6 more
openaire   +2 more sources

Gastrointestinal Intolerance and Bleeding with Non-Narcotic Analgesics

Drugs, 1986
Aspirin and paracetamol (acetaminophen) are the most commonly used minor analgesics, but their effects on the gastrointestinal tract differ widely. The effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), including phenylbutazone, are intermediate.
openaire   +2 more sources

Potentiation of a non-narcotic analgesic, dipyrone, by cholinomimetic drugs

Psychopharmacologia, 1972
Dipyrone analgesia in mice was potentiated by physostigmine, neostigmine and pilocarpine. This potentiation was antagonized by atropine sulfate and atropine methyl nitrate. Tremorine and dextroamphetamine which implicate brain monoamines in their analgesic effects, were inactive, as were carbachol and nicotine.
U G, Kamat, R J, Pradhan, U K, Sheth
openaire   +2 more sources

Blockade by l-lysine of non-narcotic analgesics.

The Journal of Pharmacology and Experimental Therapeutics, 1980
The antinociceptive effects of the non-narcotic analgesics clonixin, flunixin, acetylsalicylic acid, aminopyrine and phenylbutazone in the yeast paw test were blocked by l-lysine. Blockade occurred at doses of l-lysine which did not affect pain threshold. The site(s) or mechanism of action of blockade could not be determined with certainty.
L C, Iorio, M, Latranyi, E, Heath, A, Barnett   +3 more
openaire   +2 more sources

Non-Narcotics and Co-Analgesics

1984
Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are the most important of the non-narcotic analgesics. As simple analgesics they have equal potency but paracetamol is generally better tolerated, particularly with regard to gastrointestinal side-effects1.
openaire   +1 more source

Impact of non-narcotic oral analgesics on pain management

The American Journal of Medicine, 1988
Of the four categories of oral analgesics, three have been available since the 19th century. Although adequate doses of the more potent oral opioids such as morphine and methadone are effective even in severe pain, the commonly used "weak" narcotics such as codeine and propoxyphene are no more effective than usual doses of aspirin or acetaminophen ...
openaire   +2 more sources

Side Effects of Non-Narcotic Analgesics as a Determinant of Prescribing

Drugs, 1986
In the prescription of non-narcotic analgesics the physician's main responsibility is to make sure that the quality-of-life improvement expected from the drug's use justifies the associated risk, low though it is, of fatal side effects. The range of acceptable risk depends, naturally, on the dosage and duration of the treatment and on those ...
openaire   +2 more sources