Results 91 to 100 of about 10,900 (134)

[Mode of action of non-narcotic analgesics].

Revue du rhumatisme et des maladies osteo-articulaires, 1992
According to Lim's experiments, non-narcotic analgesics are usually considered as "peripherally" acting drugs. Conversely, most of these compounds were shown to easily cross the blood-brain barrier, and hence partly produce their effects by a central mechanism. The relative contribution of each site of action may vary from one drug to another.
B, Bannwarth, A, Chaslerie, T, Schaeverbeke, G, Vinçon, J, Dehais, B, Begaud   +5 more
openaire   +1 more source

Floctafenine, a new non-narcotic analgesic.

Archives internationales de pharmacodynamie et de therapie, 1975
Floctafenine has been studied in comparison with acetyl-salicylic acid, indomethacin and d-propoxyphene in a series of tests for analgesic and anti-inflammatory activity. It is very active in the acetic acid-induced writhing test and on the inflamed paw in the Randall and Selitto test. Furthermore, like acetylsalicylic acid and indomethacin, but unlike
M, Peterfalvi, R, Deraedt, J, Benzoni, L, Chifflot, R, Fournex   +4 more
openaire   +1 more source

The toxicology of non-narcotic analgesics.

Agents and actions. Supplements, 1986
The fact that aminopyrine is readily nitrosated and that the nitrosation product, dimethylnitrosamine, is potentially carcinogenic has led to the drug being withdrawn from therapeutic use. In the case of the other analgesics, nitrosation is not of any importance, neither in toxicological nor quantitative terms.
openaire   +1 more source

Tazadolene: A centrally‐acting, non‐narcotic analgesic

Drug Development Research, 1988
AbstractIntravenous tazadolene elevated the threshold stimulus for rabbits to respond to electrical tooth‐pulp stimulation. Systemic tazadolene also increased the latency for mice to lick their paws in the hot‐plate analgesic test. However, tazadolene did not alter the mouse tail flick, a spinal reflex most sensitive to analgesics acting at spinal ...
openaire   +1 more source

The Mechanism of Action of the Non-narcotic Analgesics

Medical Clinics of North America, 1968
F, Guzman, R K, Lim
openaire   +2 more sources

Promising non-narcotic analgesic techniques for labour.

Bailliere's clinical obstetrics and gynaecology, 1999
Epidural analgesia and spinal analgesia are the most effective techniques for relieving labour pain. Basically, local anaesthetics (i.e. bupivacaine) and opioids (i.e. fentanyl or sufentanil), especially when combined, produce excellent analgesia with minimal motor blockade.
F J, Mercier, D, Benhamou
openaire   +1 more source

Liver damage with non-narcotic analgesics.

Medical toxicology, 1987
Non-narcotic analgesics can produce a variety of hepatic lesions but clinically significant liver damage is uncommon with normal therapeutic use. The pattern of hepatotoxicity caused by the salicylates, non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen) and the pyrazolones differs but many of these drugs can cause generalised ...
openaire   +1 more source

[Characteristics of the action of non-narcotic analgesics in diabetics].

Farmakologiia i toksikologiia, 1985
Patients with diabetes mellitus were examined for the action of non-narcotic analgesics during oral cavity sanitation. All the drugs under study (amidopyrine, pyranal, baralgin, probon) taken per os increased the threshold of tactile painful sensitivity and the threshold of pain endurance in patients with diabetes mellitus to a greater degree than in ...
M V, Komendantova, E A, Ermakova
openaire   +1 more source

Pharmacotherapy I: Non-Narcotic Analgesics

Dental Clinics of North America, 1978
openaire   +2 more sources

Non-Narcotic Analgesics: Use in the Breastfeeding Woman

Journal of Human Lactation, 1989
L L, Moore, L L, Toll
openaire   +2 more sources