Results 131 to 140 of about 153,649 (263)

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Overprescribing of potentially harmful medication: an observational study in England’s general practice

BJGP Open
Background: Overprescribing of potentially harmful medication in UK general practice has a complex association with socioeconomic deprivation. Aim: To assess trends in general practice prescribing of five high-risk medications and their relationship with
Tasneem Khan, Bethan Copsey, Paul Carder, Stella Johnson, Mohammed Imran, Kaiwen Wang, Sarah Alderson   +6 more
doaj   +1 more source

Potent analgesic effects of a store-operated calcium channel inhibitor

, 2013
Ruby Gao, Xinghua Gao, Jingsheng Xia, Yuzhen Tian, James E. Barrett, Yue Dai, Huijuan Hu   +6 more
openalex   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Opioidni analgetici [PDF]

Vojnosanitetski Pregled, 2004
Vučković Sonja M., Prostran Milica Š., Ivanović Milovan D., Todorović Zoran M., Stojanović Radan M., Nešić Zorica I., Matić Ivana, Milovanović Slobodan R.   +7 more
doaj   +1 more source

Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats [PDF]

, 2010
Gin C. Hsieh, Madhavi Pai, Prasant Chandran, Bradley A. Hooker, Chang Zhu, Anita K. Salyers, Erica J. Wensink, Cenchen Zhan, William A. Carroll, Michael J. Dart, Betty Yao, Prisca Honoré, Michael D. Meyer   +12 more
openalex   +1 more source

From Chemical Burn to Below Knee Amputation: Amputation Secondary to Application of Over-the-Counter Topical Analgesic With Menthol and Methyl Salicylate [PDF]

, 2021
Rohan Desai, Jesús Llorente Gutiérrez, Sundar Cherukuri, Jesús Grávalos Guzmán, Abhizith Deoker   +4 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Differential Prescribing of Opioid Analgesics According to Physician Specialty for Medicaid Patients with Chronic Noncancer Pain Diagnoses

, 2020
Chris Ringwalt, Hallam Gugelmann, Mariana Garrettson, Nabarun Dasgupta, Arlene E. Chung, Scott Proescholdbell, Asheley Cockrell Skinner   +6 more
openalex   +1 more source