Results 161 to 170 of about 283,091 (360)

Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identified that STK33 may serve as a target of Bufalin, which induces the degradation of STK33 and inhibits the growth of TNBC. Furthermore, STK33 is highly expressed in TNBC and enhances TNBC cell proliferation by phosphorylating and stabilizing CCAR1.
Shilong Jiang, Junyan Liu, Hui Li, Chan Zou, Xiaoya Wan, Rong Gong, Ting Jiang, Changxin Zhong, Zonglin Chen, Zewu Zhu, Dongsheng Cao, Yan Cheng   +11 more
wiley   +1 more source

Editorial: Preclinical Animal Models and Measures of Pain: Improving Predictive Validity for Analgesic Drug Development

Frontiers in Pain Research, 2022
Anke Tappe-Theodor, S. Stevens Negus, Thomas J. Martin   +2 more
doaj   +1 more source

Effects of multidisciplinary inpatient rehabilitation for chronic back or neck pain: a register-linkage study of sickness absences and analgesic purchases in an occupational cohort [PDF]

, 2008
Hinkka, K, Kivimaki, M, Klaukka, T, Oksanen, T, Pentti, J, Suoyrjo, H, Vahtera, J   +6 more
core   +1 more source

A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy [PDF]

, 2015
Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol
COLUZZI, FLAMINIA, MATTIA, Consalvo
core  

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. VIII.1) Synthesis of N-Methyl-16-aza-des-N-morphinan (N-Methyl-4b, 9-methanoiminomethano-4b, 5, 6, 7, 8, 8a, 9, 10-octahydrophenanthrene

, 1956
Norio Sugimoto, Susumu Ohshiro
openalex   +2 more sources

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Anesthesia and perioperative pain management during cardiac electronic device implantation

Journal of Pain Research, 2017
Marina Biocic,1 Dijana Vidosevic,2 Matija Boric,1,3 Teo Boric,4 Lovel Giunio,2 Damir Fabijanic,2 Livia Puljak1,5 1Laboratory for Pain Research, University of Split School of Medicine, 2Department of Cardiology, 3Department of Abdominal Surgery ...
Biocic M, Vidosevic D, Boric M, Boric T, Giunio L, Fabijanic D, Puljak L   +6 more
doaj  

External Hysterographic Studies of the Effect of Certain Analgesics and Anesthetics Upon the Parturient Human Uterus.*

, 1933
Samuel M. Dodek
openalex   +1 more source