Results 171 to 180 of about 460,894 (401)

Overprescribing of potentially harmful medication: an observational study in England’s general practice

BJGP Open
Background: Overprescribing of potentially harmful medication in UK general practice has a complex association with socioeconomic deprivation. Aim: To assess trends in general practice prescribing of five high-risk medications and their relationship with
Tasneem Khan, Bethan Copsey, Paul Carder, Stella Johnson, Mohammed Imran, Kaiwen Wang, Sarah Alderson   +6 more
doaj   +1 more source

A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy [PDF]

, 2015
Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol
COLUZZI, FLAMINIA, MATTIA, Consalvo
core  

ANALGESIC ACTIVITY OF DIPIPANONE HYDROCHLORIDE IN STUDENT VOLUNTEERS [PDF]

, 1957
D. A. Cahal
openalex   +1 more source

Aptamer‐Mediated Artificial Synapses for Neuromorphic Modulation of Inflammatory Signaling via Organic Electrochemical Transistor

Advanced Science, EarlyView.
An aptamer‐mediated neuromorphic interface based on organic electrochemical transistors selectively transduces interleukin‐6 (IL‐6) signals into neuromorphic electrical outputs. This protein‐driven neuromorphic plasticity, responsive in physiological and in vivo environmental electrolyte, bridges biochemical signaling with artificial neural encoding ...
Yuqing Ding, You Kuai, Rongpei Li, Xinzhao Xu, Bo Wang, Zhihui Wang, Yanfang Liu, Yuchao Dong, Shunjie Chen, Meng Guo, Yunqi Liu, Yan Zhao   +11 more
wiley   +1 more source

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]

, 2019
Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L, Bergese, Sergio D, Berkowitz, Richard D, Brzezinski, Marek, Cochrane, Kristina, Habib, Ashraf S, Hammer, Gregory B, Mace, Sharon E, Minkowitz, Harold S, Pan, Peter H, Wase, Linda   +10 more
core  

Studies on Synthetic Analgesics. III

, 1953
Norio Sugimoto, Seiiti Saito
openalex   +2 more sources

TISSUE DISTRIBUTION OF α‐¹⁴C‐LABELLED ALKYLOXY α‐PHENYLETHYLAMINES IN RELATION TO ANALGESIC ACTIVITY [PDF]

, 1953
J. B. Brierley, A McCoubrey
openalex   +1 more source

Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2017
A. Chang, P. Bijur, D. Esses, D. Barnaby, J. Baer   +4 more
semanticscholar   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

Being safe & taking risks : how a group of nurses managed children's pain : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Nursing at Massey University [PDF]

, 1998
A small, grounded theory study was conducted in a children's surgical ward in a large, urban teaching hospital involving registered nurse volunteers. The purpose of the study was to investigate how nurses' deal with children's acute pain.
Coup, Anne
core