Results 241 to 250 of about 175,254 (314)

Beyond associations: Navigating the safety of non-steroidal anti-inflammatory drugs (NSAIDs) in early pregnancy. [PDF]

PLoS Med
Yuen ASC, Man KKC.
europepmc   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Effects of putative chronic pain models on locomotor activity in female and male mice. [PDF]

J Pain
Santos EJ, Fonseca MM, Romero-Sandoval EA, Negus SS.   +3 more
europepmc   +1 more source

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand, Nicholas A. Buckley, Paul Stathakis, Laura James, Larry Parker, Mitchell R. McGill, Angela L Chiew   +6 more
wiley   +1 more source

Knowledge, Attitudes, and Practices (KAP) survey of caregivers of children undergoing plasma tonsillectomy and adenoidectomy regarding postoperative pain management. [PDF]

BMC Pediatr
Zhang L, Liu F, Chen J, Zhong L, Wu J.
europepmc   +1 more source

From Executor to Orchestrator: The Pharmacology Scientist in the Age of Agentic AI

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development productivity has not improved despite five decades of computational advancement, with the probability that a compound entering Phase I achieving regulatory approval remaining near 10%. Each automation wave increased throughput while leaving the interpretive bottleneck intact; scientists continued to formulate questions, evaluate ...
Michael McCoy, Matthew McCoy
wiley   +1 more source

Effect of adding dexmedetomidine to fascia iliaca compartment block on postoperative analgesia in patients undergoing femoral fractures surgery: A randomized double-blind clinical trial. [PDF]

J Int Med Res
Karami N, Karami T, Taleb H, Ghodratizadeh M.   +3 more
europepmc   +1 more source

Evaluation of interprofessional collaboration in a teaching session in patient partnership in pharmacy education

The Curriculum Journal, EarlyView.
Abstract Patient partnership in health education promotes collaborative and humanistic care. In pharmacy education, however, this approach remains uncommon. We aimed to co‐construct and assess a teaching session on pain management and dispensing refusal, involving patients as full partners. A participatory approach was used.
Marc‐Antoine Luc, Guillaume Hache, Caroline Hache   +2 more
wiley   +1 more source

Upper limb paresis due to herpes zoster successfully managed in an outpatient setting: a case report. [PDF]

J Med Case Rep
Kozu Y, Kozu H, Gon Y.
europepmc   +1 more source