Results 1 to 10 of about 11,244 (259)

Isolation and Characterization of the Wastewater Micropollutant Phenacetin-Degrading Bacterium Rhodococcus sp. Strain PNT-23 [PDF]

Microorganisms, 2023
Phenacetin, an antipyretic and analgesic drug, poses a serious health risk to both humans and aquatic organisms, which is of concern since this micropollutant is frequently detected in various aquatic environments.
Yaxuan Yuan, Kexin Wang, Yihe Liu, Maoting Jiang, Yinhu Jiang, Jiguo Qiu   +5 more
doaj   +2 more sources

Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Pharmacovigilance has revealed an alarming correlation between certain medications and a higher risk of cancer. In this narrative review, included research from 2020 to 2025, along with a few seminal older studies, so that it provides a clear picture of which drugs actually set off cancer and mechanisms involved at the molecular ...
Seyoum Tadesse D, Tekletsadik K, Begashaw B, Shewasinad Yehualashet A, Mekonnen Ali A, Ayenew KD.   +5 more
europepmc   +2 more sources

Effects of Botrychium ternatum (Thunb) Sw. On Cytochrome P450 Activities in Rats. [PDF]

Pharmacol Res Perspect
Pharmacokinetic effects of Botrychium ternatum (Thunb) Sw. on cytochrome P450 activities. ABSTRACT Drug interactions commonly occur through the activities of cytochrome P450 (CYP). In this study, we evaluated the effects of the Chinese herbal medicine Botrychium Ternatum (Thunb) Sw. (BT) on six CYP enzymes.
Yao J, Hu L, Zhou Q, Al Mamun A, Wang S, Han A.   +5 more
europepmc   +2 more sources

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +2 more sources

Kinetic and Isotherm Studies of the Adsorption Phenacetin onto Two Copper Porous Coordination Compounds: Nonlinear Regression Analysis [PDF]

Journal of Chemistry, 2022
Two coordination compounds, copper (II) fumarate (CuFum) and copper (II) tartrate (CuTart), synthesized from copper (II) with fumaric acid and tartaric acid as ligands and using the slow evaporation method have been applied to study the adsorption of ...
Djoumbissie Alvine Loris, Tchuifon Tchuifon Donald Raoul, Atemkeng Donlifack Cyrille, Kuete Tiotsop Idris-Hermann, Doungmo Giscard, Tayo Djampouo Alain Clovis, Anagho Solomon Gabche, Ngoune Jean   +7 more
doaj   +2 more sources

Discovery of flavonoids as potent inhibitors of CYP1A to alleviate cellular inflammation and oxidative stress induced by benzo[a]pyrene-induced high CYP1A expression [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
The environmental pollutant benzo[a]pyrene (BaP) can induce cytochrome P450 family 1 subfamily A (CYP1A) or generate metabolic products that disrupt the balance of oxidative stress, triggering inflammatory responses in the lungs and leading to tissue ...
Xiao-Dong Li, Nan-Shan Ma, Ci-Ye He, Li-Wei Zou, Jing Zhang, Zhen-Hua Ni, Yang Ling   +6 more
doaj   +2 more sources

Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study [PDF]

BMC Urology, 2007
Background Use of phenacetin and other analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) potentially influences bladder cancer incidence, but epidemiologic evidence is limited.
Heaney John, Andrew Angeline S, Schned Alan, Zens Michael S, Kogevinas Manolis, Fortuny Joan, Kelsey Karl T, Karagas Margaret R   +7 more
doaj   +2 more sources

Physiologically-Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Lewis GJ, Jewell RC, Krishnatry AS, Taskar KS.   +3 more
europepmc   +2 more sources

Analysis of umbilical cord tissue as an indicator of in utero exposure to toxic adulterating substances

Frontiers in Pediatrics, 2023
In utero drug exposure is a significant public health threat to the well-being and normal development of the neonate. Recently, testing of umbilical cord tissue (UCT) has been employed to measure illicit drug exposure, as drugs used by the mother during ...
Kari M. Midthun, Brandon N. Nelson, Frederick G. Strathmann, Thom Browne, Barry K. Logan, Barry K. Logan   +5 more
doaj   +1 more source

Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents

Molecules, 2021
The thermodynamic properties of phenacetin in solid state and in saturated conditions in neat and binary solvents were characterized based on differential scanning calorimetry and spectroscopic solubility measurements.
Maciej Przybyłek, Anna Kowalska, Natalia Tymorek, Tomasz Dziaman, Piotr Cysewski   +4 more
doaj   +1 more source