Results 21 to 30 of about 11,244 (259)

Optimization of the CYP inhibition assay using LC-MS/MS

MethodsX, 2022
The data presented in this article are related to the research article entitled “Cytochrome P450 inhibition activities of non-standardized botanical products” [1], in which the possible CYP inhibitory properties of botanical products were investigated ...
Muhammad Asyraf Abduraman, Nor Hidayah Mustafa, Nik Soriani Yaacob, Azimah Amanah, Mei Lan Tan   +4 more
doaj   +1 more source

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]

, 2019
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska, De Clerck, Laura, Deforce, Dieter, Devreese, Mathias, Govaert, Elisabeth, Millecam, Joske, Schelstraete, Wim, Van Bocxlaer, Jan   +7 more
core   +1 more source

Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin

Journal of Advanced Pharmaceutical Technology & Research, 2016
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 ...
Alexander V Gerasimov, Mikhail A Varfolomeev, Marat A Ziganshin, Valery V Gorbatchuk, Il′naz T Rakipov, Alexander E Klimovitskii, Liana S Usmanova   +6 more
doaj   +1 more source

Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundVonoprazan fumarate is a potassium-competitive acid blocker that was developed as a novel acid-suppressing drug for multiple indications. As a potential alternative to proton-pump inhibitors, the determination of the drug-drug interactions is ...
Yiran Wang, Changxiong Wang, Shuanghu Wang, Quan Zhou, Dapeng Dai, Jihua Shi, Xue Xu, Qingfeng Luo   +7 more
doaj   +1 more source

Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo

Molecules, 2018
Honokiol (2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol) and magnolol (4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol) are the major active polyphenol constituents of Magnolia officinalis (Magnoliaceae) bark, which has been widely used in ...
Sang-Bum Kim, Kyu-Sang Kim, Heon-Min Ryu, Seong-Ho Hong, Bo-Kyoung Kim, Dae-Duk Kim, Jin Woo Park, In-Soo Yoon   +7 more
doaj   +1 more source

The ban on phenacetin is associated with changes in the incidence trends of upper‐urinary tract cancers in Australia

Australian and New Zealand Journal of Public Health, 2014
Background: Phenacetin is an analgesic that causes renal diseases and cancers of the upper‐urinary tract (UUT). It was banned in most countries from the late 1960s.
Sebastien Antoni, Isabelle Soerjomataram, Suzanne Moore, Jacques Ferlay, Freddy Sitas, David P. Smith, David Forman   +6 more
doaj   +1 more source

Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug

Journal of Advanced Research, 2022
Introduction: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver.
Jing Guo, Ying Xu, Li-jie Chen, Song-xia Zhang, Yu-ligh Liou, Xiao-ping Chen, Zhi-rong Tan, Hong-hao Zhou, Wei Zhang, Yao Chen   +9 more
doaj   +1 more source

Impurity occurrence and removal in crystalline products from process reactions [PDF]

, 2017
The behavior of impurities when subjected to crystallizations, and related processes such as recrystallization and reslurrying, has been reviewed with a particular focus on the years 2000–2015, but also including significant cases from outside that ...
Horgan, Danielle E., Moynihan, Humphrey A.   +1 more
core   +1 more source

N-(4-Ethoxyphenyl)-3-oxobutanamide

IUCrData, 2023
The title compound, C12H15NO3, crystallizes with Z′ = 2 in space group Pca21 with the two independent molecules having almost the same conformation, differing mostly at the end of the butanamide chain.
Sreevandana Yerramsetty, Frank R. Fronczek, Rao M. Uppu   +2 more
doaj   +1 more source

Surgical management for upper tract transitional cell carcinoma [PDF]

, 2008
This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2008, Issue 4. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic
Cohen, Nicholas P., McClinton, Samuel, N'Dow, James M. O., Nabi, Ghulam, Rai, Bhavan Prasad, Shelley, Mike   +5 more
core   +3 more sources