Results 21 to 30 of about 6,598 (209)
Increased Phenacetin Oxidation upon the L382V Substitution in Cytochrome P450 1A2 is Associated with Altered Substrate Binding Orientation [PDF]
, 2018 Leucine382 of cytochrome P450 1A2 (CYP1A2) plays an important role in binding and O-dealkylation of phenacetin, with the L382V mutation increasing substrate oxidation (Huang and Szklarz, 2010, Drug Metab. Dispos. 38:1039–1045).
Qingbiao Huang +2 more
core +2 more sources
Molecules, 2023 Benzisothiazolinone (BIT), a biocide widely used as a preservative in household cleaning and personal care products, is cytotoxic to lung cells and a known skin allergen in humans, which highlights the importance of assessing its toxicity and ...
Seong Jun Jo +5 more
doaj +1 more source
Optimization of the CYP inhibition assay using LC-MS/MS
MethodsX, 2022 The data presented in this article are related to the research article entitled “Cytochrome P450 inhibition activities of non-standardized botanical products” [1], in which the possible CYP inhibitory properties of botanical products were investigated ...
Muhammad Asyraf Abduraman +4 more
doaj +1 more source
Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo
Frontiers in Pharmacology, 2020 BackgroundVonoprazan fumarate is a potassium-competitive acid blocker that was developed as a novel acid-suppressing drug for multiple indications. As a potential alternative to proton-pump inhibitors, the determination of the drug-drug interactions is ...
Yiran Wang +7 more
doaj +1 more source
Journal of Advanced Research, 2022 Introduction: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver.
Jing Guo +9 more
doaj +1 more source
p53 mutations in phenacetin-associated human urothelial carcinomas [PDF]
, 1993 Chronic abuse of the analgesic drug phenacetin is associated with an increased risk of development of transitional cell carcinomas of the urinary tract. It is unclear whether phenacetin acts through chronic tissue damage (phenacetin nephropathy) or via a
Ohgaki, Hiroko +3 more
core +1 more source
N-(4-Ethoxyphenyl)-3-oxobutanamide
IUCrData, 2023 The title compound, C12H15NO3, crystallizes with Z′ = 2 in space group Pca21 with the two independent molecules having almost the same conformation, differing mostly at the end of the butanamide chain.
Sreevandana Yerramsetty +2 more
doaj +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2017 A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery
Liana Stanislavovna Usmanova +7 more
doaj +1 more source
N-(4-Ethoxy-2,5-dinitrophenyl)acetamide
IUCrData, 2020 In the title compound, C10H11N3O6, the torsion angles about the bonds to the benzene ring are less than 4°, except for the nitro groups, which are twisted out of the ring plane by 25.27 (3) and 43.63 (2)°.
Sannihith N. Uppu +3 more
doaj +1 more source