Results 21 to 30 of about 6,115 (211)

Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundVonoprazan fumarate is a potassium-competitive acid blocker that was developed as a novel acid-suppressing drug for multiple indications. As a potential alternative to proton-pump inhibitors, the determination of the drug-drug interactions is ...
Yiran Wang, Changxiong Wang, Shuanghu Wang, Quan Zhou, Dapeng Dai, Jihua Shi, Xue Xu, Qingfeng Luo   +7 more
doaj   +1 more source

Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug

Journal of Advanced Research, 2022
Introduction: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver.
Jing Guo, Ying Xu, Li-jie Chen, Song-xia Zhang, Yu-ligh Liou, Xiao-ping Chen, Zhi-rong Tan, Hong-hao Zhou, Wei Zhang, Yao Chen   +9 more
doaj   +1 more source

p53 mutations in phenacetin-associated human urothelial carcinomas [PDF]

, 1993
Chronic abuse of the analgesic drug phenacetin is associated with an increased risk of development of transitional cell carcinomas of the urinary tract. It is unclear whether phenacetin acts through chronic tissue damage (phenacetin nephropathy) or via a
Ohgaki, Hiroko, Petersen, Iver, Ludeke, Barbara I, Kleihues, Paul   +3 more
core   +1 more source

Phenacetin [PDF]

Juntendo Medical Journal, 1888
n ...
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N-(4-Ethoxyphenyl)-3-oxobutanamide

IUCrData, 2023
The title compound, C12H15NO3, crystallizes with Z′ = 2 in space group Pca21 with the two independent molecules having almost the same conformation, differing mostly at the end of the butanamide chain.
Sreevandana Yerramsetty, Frank R. Fronczek, Rao M. Uppu   +2 more
doaj   +1 more source

Therapy of Phenacetine [PDF]

The Journal of Nervous and Mental Disease, 1893
n ...
openaire   +1 more source

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

Journal of Advanced Pharmaceutical Technology & Research, 2017
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery
Liana Stanislavovna Usmanova, Marat Akhmedovich Ziganshin, Valery Vilenovich Gorbatchuk, Sufia Askhatovna Ziganshina, Dmitry Anatolevich Bizyaev, Anastas Akhmetovich Bukharaev, Timur Anvarovich Mukhametzyanov, Alexander Vladimirovich Gerasimov   +7 more
doaj   +1 more source

N-(4-Ethoxy-2,5-dinitrophenyl)acetamide

IUCrData, 2020
In the title compound, C10H11N3O6, the torsion angles about the bonds to the benzene ring are less than 4°, except for the nitro groups, which are twisted out of the ring plane by 25.27 (3) and 43.63 (2)°.
Sannihith N. Uppu, Ogad A. Agu, Curtistine J. Deere, Frank R. Fronczek   +3 more
doaj   +1 more source

Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method

Frontiers in Pharmacology, 2021
Poziotinib is an orally active, irreversible, pan-HER tyrosine kinase inhibitor used to treat non-small cell lung cancer, breast cancer, and gastric cancer.
Jinhui Wang, Feifei Chen, Hui Jiang, Jia Xu, Deru Meng, Peiwu Geng, Dapeng Dai, Jingbo Hu, Yunfang Zhou, Quan Zhou, Shuanghu Wang   +10 more
doaj   +1 more source

Physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin

Results in Chemistry
Substituting hydrogen atoms with fluorine alters physicochemical properties often resulting in improved drug action relative to the parent molecule. The high electronegativity of fluorine changes the electron density distribution of the molecule; however,
Hannah L. Cure, Thomas A. Shell
doaj   +1 more source